The Valorant LOCK//IN 2023 tournament begins next week and will have Twitch/YouTube drops enabled for players. There will be two rewards available to acquire.

Using MRI scans to screen men for prostate cancer could reduce deaths from the disease “significantly”, researchers have suggested. Scientists said current tests, which detect the level of the protein prostate-specific antigen (PSA) in the blood, have been linked to over-diagnosis and over-treatment of low-risk cancer. Prostate cancer is the most common cancer found in men and, at the moment, those aged over 50 can request a PSA test if they are experiencing symptoms. The Reimagine study invited 303 men aged between 50 and 75 to have a screening MRI and a PSA test. Of the total, 48 (16 per cent) had an MRI that indicated the presence of prostate cancer despite having a median PSA density. Of the group, 32 had lower PSA levels than the current screening benchmark of 3ng/ml, meaning they would not have been referred for further investigation. After NHS assessment, 29 men were diagnosed with cancer that required treatment, 15 of whom had serious cancer and a PSA of less than 3ng/ml. Three men (1 per cent) were diagnosed with low-risk cancer that did not require treatment. Our results give an early indication that MRI could offer a more reliable method of detecting potentially serious cancers early Prof Caroline Moore The study was led by University College London, University College London Hospitals NHS Foundation Trust and King’s College London and is published in medical journal BMJ Oncology. Prof Caroline Moore, consultant surgeon at UCLH, chief investigator of the study and NIHR research professor, said the findings are “sobering” and “reiterates the need to consider a new approach to prostate cancer screening”. “Our results give an early indication that MRI could offer a more reliable method of detecting potentially serious cancers early, with the added benefit that less than 1 per cent of participants were ‘over-diagnosed’ with low-risk disease,” she added. Prof Mark Emberton, consultant urologist at UCLH, said: “The UK prostate cancer mortality rate is twice as high as in countries like the US or Spain because our levels of testing are much lower than other countries. “Given how treatable prostate cancer is when caught early, I’m confident that a national screening programme will reduce the UK’s prostate cancer mortality rate significantly. There is a lot of work to be done to get us to that point, but I believe this will be possible within the next five to ten years.” Nick James, a professor of prostate and bladder cancer research at the Institute of Cancer Research in London said the study “further reinforces the value of MRI in the diagnostic pathway for prostate cancer”. “The well-known limitations of the old PSA-based screening studies of over- diagnosis and linked over-treatment are increasingly mitigated by the use of MRI,” he added. “Similarly, MRI can also spot cases of prostate cancer in patients with normal PSA levels, who would have been missed using PSA only screening programmes.” MRI scans have revolutionised the way we diagnose prostate cancer, and it’s great to see research into how we might use these scans even more effectively Simon Grieveson, Prostate Cancer UK Prof Sir Mike Richards, chairman of the UK National Screening Committee (NSC), said the organisation does not currently recommend prostate cancer screening “because there is no clear evidence that the benefits outweigh the harms”. However, it is preparing to look at various proposals. He added: “The UK NSC will soon commission a major piece of work to consider six prostate cancer screening proposals that were submitted during its annual call for topics. “These include targeted and risk-stratified screening proposals for screening groups of men at higher risk due to factors such as ethnicity and family history.” Simon Grieveson, assistant director of research at Prostate Cancer UK, said: “MRI scans have revolutionised the way we diagnose prostate cancer, and it’s great to see research into how we might use these scans even more effectively. “These results are extremely exciting, and we now want to see much larger, UK-wide studies to understand if using MRI as the first step in getting tested could form the basis of a national screening programme.” Another trial, known as Limit, is being conducted with a much larger number of patients, which the research team said is the “next step towards a national prostate screening programme”. The trial will also attempt to recruit more black men, after the team behind Reimagine found they were much less likely to respond to the invitation to screening than others. Saran Green of King’s College London said: “One in four black men will get prostate cancer during their lifetime, which is double the number of men from other ethnicities. “Given this elevated risk, and the fact that black men were five times less likely to sign up for the Reimagine trial than white men, it will be crucial that any national screening programme includes strategies to reach black men and encourage more of them to come forward for testing.”

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A man who says he is armed has barricaded himself in a room at Caesars Palace in Las Vegas, police say, where the individual is holding a female hostage. The Las Vegas Metropolitan Police Department said they received a complaint of a domestic disturbance at around 9.15am on Tuesday. When they arrived at the hotel and casino on the Las Vegas Strip, the man refused to come out and told officers he was armed, police said. Vegas police said the man pulled a woman into his room “by force” and that she remains inside. “She is still in the room at this time,” a police spokesman said on Tuesday morning during a press update. “The female has been heard from and is still OK.” The officer added that no shots have been fired and no weapons have been seen. SWAT teams and crisis negotiators have been sent to the hotel on the 3500 block of South Las Vegas Boulevard. Police asked residents to avoid the area and watch out for emergency personnel. “We are actively trying to resolve this situation,” the LVPD said in a tweet. North Carolina real estate broker Alyssa Hellman told The Independent she was at the Caesars Palace pool with her wife when she heard a loud bang at about 1.30pm. She said she looked up to see that a window had been broken on about the 10th floor, and a man inside started throwing furniture out onto the concourse. “We heard a bang and then one of the windows was broken open, and the guy was throwing things out. Lamps, a TV and a minibar. He’s drawn the curtains now,” Ms Hellman said. Ms Hellman said guests were evacuated from the pool area, but staff did not explain what was going on. The couple had retreated to a safe distance and said everyone around them seemed “pretty calm and content”. “We’re tucked back hidden away, closer to the Bellagio,” she said. A video posted to Twitter showed security guards duck for cover as a television fell to the ground behind them. One guest told 8NewsNow that she had been swimming in the pool when a security guard ordered everybody out. The witness said she saw chairs being thrown from a window, which appeared to be completely smashed out. Caesars Entertainment said in a statement: “We are aware of the security incident at Caesars Palace. Our team is cooperating fully with law enforcement officers on scene who are handling the investigation.” Read More Caesars Palace standoff news - live: SWAT teams respond to ‘armed’ man barricaded in Las Vegas hotel room Las Vegas police officer set to go on trial over $165k stolen in 3 casino heists Oklahoma county sheriff and three other officials allegedly caught on tape talking about killing journalists Ex-student sentenced to 16-plus years in prison for 2022 attack on Las Vegas high school teacher

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