KELOWNA, British Columbia--(BUSINESS WIRE)--Sep 27, 2023--

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A new study has found that placenta abnormalities could be the reason for miscarriages. In the United States, there are approximately 5 million pregnancies per year with 1 million ending in a miscarriage and over 20,000 ending in stillbirth, according to a paper published in the journal Reproductive Sciences. “To have a pregnancy loss is a tragedy. To be told there is no explanation adds tremendous pain for these loss families,” said senior author of the paper and research scientist at Yale School of Medicine, Dr Harvey Kliman “Our goal was to expand the current classification systems to decrease the number of cases that remained unspecified.” For the study, researchers worked to create a classification system for miscarriages based on a test that examines a sample of the body’s tissues – known as pathologic examination. The team looked at a series of 1,527 single-child pregnancies that ended in miscarriage, and the data was then sent to Yale for evaluation. After excluding cases without adequate material for examination, 1,256 placentas from 922 patients were examined. Of these, 70 per cent were miscarriages and 30 per cent were stillbirths. By adding the explicit categories of “placenta with abnormal development” (dysmorphic placentas) and “small placenta” (a placenta less than the 10th percentile for gestational age) to other incidents such as cord accident, abruption, thrombotic, and infection – researchers were able to determine the results of 91.6 per cent of the pregnancies, including 88.5 per cent of the miscarriages and 98.7 per cent of the stillbirths. The most common results for unexplained miscarriages were dysmorphic placentas (placenta with abnormal development) which was around 86.2 per cent. For stillbirths, there was 33.9 per cent due to a small placenta. “This work suggests that the over 7,000 small placentas per year associated with stillbirths could have been detected in utero — flagging those pregnancies as high risk prior to the loss,” said Dr Kliman. “Likewise, the identification of dysmorphic placentas may be one way to potentially identify genetic abnormalities in the almost 1 million miscarriages that occur in our country every year.” He said having a definite explanation “for a pregnancy loss helps the family understand that their loss was not their fault, allows them to start the healing process, and, when possible, prevent similar losses — especially stillbirths — from occurring in the future.” When asked what the most effective way might be to prevent stillbirths, Dr Kliman responded, “Measure the placenta!” Read More 'Please, keep beating little heart': Man gives raw account of wife's miscarriage and fears for new unborn child Woman who had six miscarriages celebrates pregnancy with rainbow baby photoshoot Miscarriage: The loneliest grief of all Nearly a fifth of parents fear children will ignore health issues while at university Brits feel their mental health declining due to cost of living crisis How often should you wash your pyjamas?

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Over the past few months, as Chelsea’s hierarchy started to settle into the club, they became fixated on a specific idea relevant to this weekend’s game. They began to study what makes 100-point seasons and record-breaking sides. That might seem some way off, to an almost comic degree, but you’ve got to have goals. Manchester City are the obvious case study, since they are the only club to manage a centurion season and they still break records. As regards what made that possible, the usual explanation might be “one of the most lavishly expensive football projects in history” but Chelsea’s owners also have huge resources and are clearly willing to spend them. Their outlay on transfer fees so far, if not quite wages, has recalled the dizzy days of Roman Abramovich between 2003 and 2006 and the first few years of the Abu Dhabi ownership at City. And Chelsea might have a more specific reason to look at the European champions for inspiration. Chelsea’s own grand project, which is an unprecedented football experiment, is based on bringing in young players of a similar talent profile to Jeremy Doku. That raises the obvious question of whether Doku would have the same impact if he was at Chelsea? Or, would he be just another young signing showing potential but requiring shape and direction? Recent form suggests the latter. There are caveats, of course. It is early days and, as good as Doku has been, the real tests will come later. Clubs like Manchester United and Newcastle had also looked at him, but felt he wasn’t yet developed enough. There was a sense he was too erratic as a player. However, his impact under Pep Guardiola, especially when contrasted with Raheem Sterling’s influence on Chelsea, speaks volumes about the two clubs. One significant difference between Doku and so many similar young players at Chelsea is the roles they’ve been signed for. The London club have attempted to overhaul their entire squad, and players of talent have just been thrust into the fray. It has been up to Mauricio Pochettino to make sense of it. City, from the benefit of over a decade’s planning, can be much more forensic. Their succession plans are so well defined and far-thinking, with most signings settled on at least 18 months in advance - barring any unseen changes like the sudden impact of Saudi Pro League money, which delayed this summer’s business. Doku was supposed to be next in line in City’s attack but, as occasionally happens in teams that are so high-functioning, a player of his talent has been able to slot right in. It has even gone a little bit in the other direction, in how Doku’s livewire play actually gives City’s smoothness something different. It’s hard not to have some sympathy with Jack Grealish. When he was signed, Guardiola worked on him for weeks, seeking to change his thinking on the game and add much more control to it. Grealish was still talking about how he needed to evolve by the end of a season where he’d won his first title. Doku, by contrast, has just been put in the team and let loose to also leave Grealish on the bench. This isn’t to say the English playmaker should be overly worried about his medium-to-long-term role. As Sterling knows better than anybody, Guardiola goes on and off players all the time. It is partly his way of keeping them on their toes, partly tactical experimentation, partly man-management and partly what fits at any given time. Sterling ultimately felt he didn’t have that time, and sought to be a more influential player at another major club. There is something of an irony there, though. While Sterling is Chelsea’s senior attacker, who has a huge burden in leading the play, his best role is probably as someone who works off other stars and does real damage there. That is when his running on the ball and off it can be devastating. The farcical match against Tottenham Hotspur on Monday showed how much focus there can be on Sterling in this Chelsea team, although it had the effect of releasing Nicolas Jackson for so many chances that he eventually got a hat-trick by sheer force of numbers. While there will be an obvious comparison between that and Doku’s impact against Bournemouth, they were very different types of performances. They are very different types of roles. At Chelsea, attackers like Jackson and Cole Palmer already have a huge responsibility, which increases the burden on Sterling. At City, Doku is able to play off a series of stars who know precisely what their job is. It means he can figure out his own game, as defences try to figure him out. Read More The future of football: Why the U-17 World Cup highlights an evolving game One point: Is this the worst score of the Fantasy Premier League season? Are England’s Harry Kane and Jude Bellingham the best strike force in world football? 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