Jared Verse rushed off the edge and kept pushing

Google says it has made a significant step in identifying disease-causing genes, which could help spot rare genetic disorders. A new model named AlphaMissense is able to confidently classify 89 per cent of all possible “missense” variants in genes, identifying whether they are likely to cause diseases or benign. That compares with just 0.1 per cent of all missense variants that have been confidently classified by human experts. Missense variants happen when a single letter is substituted in the DNA, which in turn leads to proteins with a different amino acid. That small change can have significant effects – Google likened it to the way that changing a letter in one word can change the meaning of the whole sentence. Most of those variants are benign: the average person has more than 9,000 of them. But some of them can be disastrous, leading to rare genetic diseases. The new AlphaMissense looked at existing information about missense variants, and how commonly they are seen in humans and closely-related primates. It looked for those that were rarely seen, classifying them as pathogenic, and from that was able to use that information to analyse other protein sequences – giving not just a verdict on whether they were likely to cause problems, but also how confident it was. Experiments, conducted by humans, which look to find those mutations are expensive and slow: they require people to examine each unique protein and designed separately. Google says that the new system means that researchers can “preview” those results for thousands of proteins at a time, helping them decide where to focus. The company has used its systems to release a vast catalogue of “missense” mutations, so that researchers can learn about what effect they have. In some cases, those variations can lead to conditions such as cystic fibrosis, sickle-cell anaemia, or cancer, and understanding them could be key to researchers studying ways to treat or prevent those diseases. It is just the latest health breakthrough from Google’s Deepmind division, which is looking to use artificial intelligence to both identify and treat a variety of conditions. The new system was built on AlphaFold, the breakthrough model that helped unfold proteins, the building blocks of life. The research is described in a new paper, ‘Accurate proteome-wide missense variant effect prediction with AlphaMissense’, published in the journal Science. The catalogue is being made “freely available to the research community”, Google said, and the company will release the code behind the AI system. Read More BBC removes some Russell Brand content as monetisation suspended on YouTube Google Bard can now link to Gmail and other apps to help with responses Long-form video content is here to stay, says YouTube UK boss

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Leading goal scorer Denis Bouanga and Most Valuable Player Luciano Acosta were among the MLS Best 11 players named on Tuesday by the league as...

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While both of their careers were booming, their marriage was not, and Johnny Depp and Lori Depp filed for divorce in 1985

He's a big Manchester United fan, but iShowSpeed had no idea who a group of Newcastle United footballers were after they 'butchered' him during a late night Fortnite session. Three players took down iShowSpeed during his latest gaming stream, but despite being notable Premier League stars the content creator had no clue who he was up against. "Who the f*** is Harvey Barnes, bro?" iShowSpeed shouted after meeting a sticky end in the game. Harvey Barnes, as football fans know, is a talented winger on the fringes of the England squad who moved to Newcastle from Leicester in the summer. Viewers weren’t 100 per cent sure whether it was the real Harvey Barnes who had taken iShowSpeed down at first. However, he was joined by players with the aliases Anthony Gordon and Paul Dummett, who also play for Newcastle, which seemed to confirm things. "I’m creased some Fortnite pro players and Speed got butchered by Harvey Barnes, Paul Dummett and Anthony Gordon at 1am,” one social media user posted after seeing the incident unfolded. Another said: “Never thought i’d hear speed and xqc talking about harvey barnes lmfao.” One more added: “Speed getting his ass handed to him on Fortnite by Harvey Barnes is hilarious.” “A crossover we never knew we needed…” another wrote. It comes a few days after iShowSpeed attracted controversy after attempting a dangerous “coke and condom challenge” on his live stream. Sign up for our free Indy100 weekly newsletter How to join the indy100's free WhatsApp channel Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings

By Foo Yun Chee BRUSSELS (Reuters) -Microsoft Corp is expected to secure EU antitrust approval for its $69 billion acquisition

With the Lionesses’ Euro 2022-winning captain Leah Williamson forced to miss out on the World Cup through injury, coach Sarina Wiegman has entrusted the responsibility for leading the team to experienced Chelsea centre back Millie Bright. Bright has been passed fit for England’s match against Haiti after recovering from knee surgery and the defender will lead the Lionesses in their Group D opener. Now 29, Bright grew up in Chesterfield, Derbyshire, overcoming infant pneumonia and asthma to enjoy a career as a top level athlete, although her first love was equestrianism, not football. Showing early promise when she did take to the field aged nine, she was soon scouted playing for Killamarsh Dynamos by Sheffield United and joined their academy before moving to Doncaster Rovers Belles aged 16 in 2009. Making her debut that same year and scoring on her first start, Bright spent a year on loan at Leeds Ladies before establishing herself at Doncaster, where she played with future Lionesses Mary Earps and Bethany England. In December 2014, she signed for Chelsea and has remained with the West London club ever since, picking up four Barclays Women’s Super League titles, three FA Women’s Cups and reaching the UEFA Champions League Final, scoring 14 times across 218 appearances. For England, she was an essential part of the side that reached the semi-finals of the last FIFA World Cup in France in 2019 and of last summer’s triumphant Euros team. She has represented her country, to date, 66 times and scored five international goals, striking up solid defensive partnerships with Williamson and Houghton during that time and posing a significant aerial threat from set plays. Read More How to watch England vs Haiti: TV channel and start time for Women’s World Cup opener Women’s World Cup TV schedule: How to watch every match today Women’s football world rankings: Who could take No 1 at the World Cup?

Self-proclaimed 'villain' James Holzhauer triumphed with a safe bet, winning a whopping grand prize of $500K and the title of Jeopardy! Masters' champion

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Rihanna and A$AP Rocky's second child was reportedly born on August 1