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Centenarians tend to have lower levels of glucose, creatinine and uric acid from their sixties onwards, according to the largest study of its kind that may lead to a simple blood test to predict a person’s chance of reaching 100. The research, published on Monday in the journal GeroScience, is the biggest to date to measure and follow up the levels of different molecules in the blood of people born between 1893 and 1920. Scientists, including those from Karolinska Institutet, assessed the data on blood molecules from over 44,500 Swedes who underwent clinical testing between 1985 and 1996 and followed up till 2020. They focused specifically on people born between 1893 and 1920, who were between 64 and 99 years old when their blood samples were first tested, and followed them up as they grew closer to 100 years of age. About 1,200 individuals in the study, or about 2.7 per cent of the participants, reached 100. Researchers compared this subset’s data with those of their peers who were younger than them. The analysis found 12 blood-based molecules associated with metabolism, inflammation as well as liver and kidney function, that were also linked to ageing or mortality in previous studies. These molecules included total cholesterol and glucose as markers of metabolism, uric acid indicating inflammation levels, enzymes indicative of liver health and creatinine as a measure of kidney health. Researchers also looked at albumin and iron levels in the blood. Except for a liver enzyme and albumin, all other molecules were found linked to the likelihood of a person becoming a centenarian. Those with increased levels of total cholesterol and iron had a greater likelihood of becoming centenarians compared to those with lower levels. However, for molecules including glucose, creatinine, uric acid, and liver enzymes, lower levels were associated with higher chances of living past 100. “We found that, on the whole, those who made it to their hundredth birthday tended to have lower levels of glucose, creatinine and uric acid from their sixties onwards,” researchers wrote in The Conversation. “Very few of the centenarians had a glucose level above 6.5 earlier in life, or a creatinine level above 125,” they said. While the differences found in the study between groups were small in some cases, researchers said the findings still suggest a “potential link” between metabolism, nutrition and longevity. However, the study falls short of recommending lifestyle factors or genes responsible for these blood molecule levels. “While chance likely plays a role for reaching age 100, the differences in biomarker values more than one decade prior death suggest that genetic and/or lifestyle factors, reflected in these biomarker levels may also play a role for exceptional longevity,” scientists wrote in the study. “However, it is reasonable to think that factors such as nutrition and alcohol intake play a role. Keeping track of your kidney and liver values, as well as glucose and uric acid as you get older, is probably not a bad idea,” they said. Read More Good financial planning could increase life expectancy, study suggests Scientists find gene that grants long life – and successfully test it on another species Scientists extend mice lives by connecting their blood to young ones

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FaZe Clan is one of the world's most popular professional esports organisations, with members such as Twistzz, Olofmeister, Rain and now former Stranger Things actress, Grace Van Dien. The actress-turned-streamer is one of the group's newest recruits, and while many were thrilled by the news, some were left feeling confused. Some suggested Van Dien has limited gaming experience, and others have critiqued the collective for prioritising a celebrity status over a professional gamer. Sign up for our free Indy100 weekly newsletter FaZe member Rain has been particularly vocal about the group's decision, leaking the surprise to his 3.1 million followers. On her stream, Van Dien hit back: "I’m sorry sir, were you in the meeting with us? Were you there?" "No, I’ve never f**king met you and that is not why FaZe signed me. That is definitely how I got the meeting, yes, I will give that credit. That is how I got the meeting." She continued: "But, that is absolutely not why I’ve signed. The things that we spoke about in the meeting are why I have. So, get f**king wrecked to everyone saying that, to Rain saying that. Like, you weren’t there, you have no idea." On 28 May, people accused Rain of going "too far" after sharing an explicit rant about Van Dien that he later apologised for: The comments sparked a response from the actress, who brought up Rain's previous issues with drugs. "I know you, Rain, as the person who almost overdosed on a live stream," she said. "And I know that you’re better now, and I’m really proud of you for that. I am." The back-and-forth led to the pair meeting, which fans believed would have settled the conflict. During their discussion Van Dien reference an old tweet of Rain's from 2013 that made a violent suggestion about actress Emma Watson. In the end, Van Dien left the room crying and threatened to leave FaZe if the video was uploaded. In a statement from the official FaZe Twitter account, they wrote: "FaZe is no stranger to contrasting viewpoints and passionate opinions on the future of the brand. Recruitment has always drawn that out. But make no mistake, the mistreatment of our newest member is in no way OK. Grace joined in hopes to bring her voice to FaZe & we stand by her." Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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