James McCann had three hits and five RBIs and Jordan Westburg hit a three-run homer to help the Baltimore Orioles rout the Mets 10-3 in New York manager Buck Showalter’s return to Camden Yards

Ageing could soon be a thing of the past, following the latest development in chemical therapy and anti-ageing research. The research focuses on anti-ageing genes and adds to a previous study which won a Nobel Prize, focusing on small cell cultures. A team from Harvard Medical School is leading the study into genes called Yamanaka factors. The research focuses on turning cells into induced pluripotent stem cells (iPSCs), which effectively turns the cell young again. If the research targeted cells in this fashion, it could ultimately reverse the physical impacts of ageing. Sign up to our free Indy100 weekly newsletter There’s a great deal to consider when it comes to treatment like this, as the effect of ageing is a natural way the human body protects against harmful mutations like cancer. However, the new research published in the journal Aging claims that the process doesn’t create cells that are prone to cancer. The results showed that six chemical mixes were found that showed scientist could make cells biologically “younger” in the space of just seven days. After previous research conducted on mice, the team behind the study is looking to thake the study to human trials by 2024. David A. Sinclair is Professor in the Department of Genetics and lead scientist on the project. He released a statement saying: “Until recently, the best we could do was slow aging. New discoveries suggest we can now reverse it.” He added: “This process has previously required gene therapy, limiting its widespread use.” Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Alan Shearer responds to concerns over his charity taking money from Saudi-backed LIV golf league.

Stevie Nicks has admitted to being a huge fan of 'Daisy Jones and the Six', the hit TV mini-series.

LIMA, Peru--(BUSINESS WIRE)--Jun 13, 2023--

Spotify is to use Google's AI system to tailor recommendations to users - just months after it was announced that an AI translation service was on the way.

Oil headed for the biggest weekly gain since early April after Russia signaled it would extend export curbs

'It's not over for any of us until SAG-AFTRA gets their deal,' a writer said after WGA reached a tentative deal with AMPTP

Wahoo has launched the Kickr Move, a new indoor cycling trainer aimed at improving the experience of riding indoors - and overcoming a range of problems experienced by home training companies in recent years. The new Kickr Move adds movement to indoor cycling. Until now, riding a bike indoors has almost uniformly meant mounting a bike onto a smart trainer that allows for little movement, either sideways or forwards. That lack of movement in turn leads to problems with comfort, as well as realism, given that riders are stuck in the same position. In recent years, indoor cyclists have undertaken increasingly complicated ways of solving that problem, including putting their bikes and turbo trainers onto large “rocker plates” – essentially big wooden platforms intended to allow them to move a little more. Wahoo said that building a system like that was never on the table. While those rocker plates showed there was clearly an "unmet need", the company's founder Chip Hawkins told The Independent that "doesn't make any sense at all" and that the company therefore set about building a new kind of solution. Without that kind of movement, the forces that usually move a bike do not happen on a fixed trainer, which leads to "unnatural pushing and pulling", Hawkins said, which can make long rides inside uncomfortable and unrealistic. Fixing that added a completely different appeal that aims to make indoor riding more appealing, he said. Wahoo did so by taking its existing smart trainer and essentially mounting it on a track, to allow movement back and forth, with about 14cm of space back and forth. If a rider gets out of the saddle, for instance, the bike will drop back and then forward again – something that’s so natural in the real world that it hardly takes any thought, but which has been almost entirely missing in indoor cycling. (Wahoo’s rival, Tacx, released its own “Motion Plates” last year, but they are added on to the trainer separately.) The Wahoo Kickr that is on the market today looks almost identical to the one sold ten years ago, though there has been the addition of new technologies such as built-in WiFi; the new Move is the first noticeable different smart trainer Wahoo has released in years. Even in the new release, the changes are minimal: the Kickr Move takes most of the components from Wahoo’s existing smart trainer and puts them in that track. At the same time, it has also announced a new, cheaper version of its premium Kickr Bike, an entire indoor bike, aimed at broadening the appeal. But even if the changes are humble, the new Kickr Move marks the first major change to the design of indoor bike training equipment in years. And, perhaps more importantly, they come at a time when the future of indoor cycling's future is being decided. Indoor cycling as an industry and an activity has been no stranger to dramatic movements in recent years. When the pandemic began, early in 2020, many took to working out indoors, and the connected fitness and indoor training industry experienced a surge in demand so strong that it became a problem. For the first year, Wahoo and other indoor training companies couldn't make enough stock to sell, and as soon as turbo trainers appeared on retailers' websites they would disappear again. Orders came in and shops stocked up heavily, to avoid any similar difficulties in the years to come; factories were coming back online and were ready to make those smart trainers. "And then everyone went outside," Hawkins recalls. All of the indoor training equipment that had been ordered had nowhere to go. "Our sales took a horrible nosedive." Prices were reduced to clear out those now full shelves at bike shops, and sales fell too. "It was a really, really tough year last year," Hawkins says. This time around, as the autumn approaches and trainer season begins again, the industry is having the opposite problem: for the most part, that glut of trainers has been sold, but bike shops are anxious about ordering too much to replace them. What's more, the effect of the pandemic on bikes was much the same – bikes were impossible to buy, so more were made, and they are now stuck on shelves – meaning that those shops might not have space or money to buy trainers even if they wanted to. At the same time, things were looking especially shaky at Wahoo. At the height of covid – when people wanted indoor fitness equipment, and investors wanted the companies that make them – Wahoo was sold to a private equity firm. Wahoo commanded a chunky valuation as the lockdown sales rolled in, benefiting from the same excitement that also sent the share price of rivals Peloton soaring. Then lockdowns eased, and people started leaving the house. Interest in indoor cycling started to fall away. Peloton’s stock plummeted; it has lost 97 per cent of its value since its highs in early 2021. Wahoo’s financial analysts started to use words like “unsustainable” about the company, and it looked as if its debt problems could lead the company to collapse. Some 18 months after a sale built on frenzied excitement about indoor cycling, Wahoo looked in peril. The debt taken on to support the sale was called in and the company was taken over by the banks, and the "shareholders lost everything", Hawkins said. Wahoo's marketing activities went away, product development slowed, staff were let go, and the company looked in danger. Then Hawkins stepped back into buy the company, along with three other strategic investors. It was a "fresh start", he says, and the company was free of its debt. Wahoo's operations "never really missed a beat" throughout the financial chaos, and so the company was able to get back to work again. "We're not trying to raise quick bucks or anything – I'm really trying to set us up for long-term success, which is exciting", he says. The Kickr Move and the Bike Shift are the first major new products to come out of Wahoo since all of that happened. As well as the new products, it comes with a new approach: more sustainable packaging, and a new setup experience – as well as a new, higher price. The Kickr Move costs £1,399 – £300 more than the existing Kickr smart trainer, which will stay on the market. Encouraging people to pay that extra might be difficult, given so many cyclists have just bought trainers in recent years, especially through the pandemic. But Hawkins says that while the market might look mature, there are still plenty of people out there still to be reached. Hawkins' instinct is that indoor cycling is a mature market, but Wahoo's data suggests that only 11 per cent of "committed cyclists" have a smart trainer. "There is still a tonne of people that haven't discovered smart training yet – I don't know exactly where they are, but it seems like there is a lot of room for kind of continuing to expand the category". The Kickr Move is another attempt to reach those people, as well as being extra innovation intended to make those with older trainers upgrade. In use, the Kickr Move is considerably more comfortable: it is hard to understand how much discomfort is caused by a lack of movement until you're able to move back and forth. And the relative lack of innovation elsewhere means that setting up the new trainer is familiar and simple, and that it works easily with Wahoo's other products. (The only problem is Wahoo's Kickr Climb, which allows people to tilt the front of their bike up and down as if they were ascending and descending, and which needs an extra foot to be compatible with the Kickr Move, sold separately.) The new trainer is far from the only innovation planned by Hawkins in the time to come. "You've got other things coming besides this launch," he teases; "we are 10, 12 years old in this market, compared to 150-years or something for cycling. So I think we've got a long way to go." Read More Apple is about to launch what could be the most controversial iPhone in years Apple is about to reveal the new iPhone – and a lot more Here’s when you will actually be able to get the new iPhone Apple is about to launch what could be the most controversial iPhone in years Apple is about to reveal the new iPhone – and a lot more Here’s when you will actually be able to get the new iPhone

It is a chilling statement uttered with the most flattering of intentions: “We’re dealing with a freak.” Those are the words of boxing promoter Ben Shalom, speaking over Zoom, pacing back and forth in a room that appears to have just a few small windows – just below the ceiling, along the back wall. You’d think he was a military commander fruitlessly planning how to take down Godzilla, but the Boxxer chief is in fact on the side of the monster in question here. And that monster is Adam Azim. It might seem an odd way to describe the 5ft 11in, 20-year-old super-lightweight, but put a pair of boxing gloves on the Briton and the results really are terrifying. “I remember when I was four years old,” the monster tells The Independent while lurking in a hallway inside Shane McGuigan’s gym. “My dad made me learn the basics at the back of the garden in Slough, he got me a speed ball in the garage. He used to put weighted hand wraps on me and make me do shadow boxing for like 20 minutes straight. Even when I was punching the speed ball, he used to put ankle weights on my legs and hands. I was very fast when I was young.” He is even faster now, his speed perhaps his greatest asset at this point in a fledgling professional career that is expected to grow into a captivating one. “When we saw him for the first time, we knew he was special,” says Shalom. “Everyone in boxing was talking about Adam Azim for a long time. We knew that a lot of promoters were going to be looking at him, and that we needed to secure him for a long time, because we believe that he can be literally one of the biggest stars that the country has seen – a household name. “We want him on the screens all the time. He almost reminds me of Amir Khan in 2005. Those were some of my earliest memories of boxing, Amir was boxing every couple of months on ITV and drawing huge audiences. We want to emulate that and take that to a new level.” Azim is still just 8-0, but with six emphatic knockout wins. “He looks at a lot of the world champions and believes that he would beat them in his next fight,” Shalom says, unquestionably serious, his eyes shark-like. “And Shane believes that. This is not a joke. “It’s high-risk, low-reward [for opponents]. I cannot tell you how feared this guy is; there’s world champions right now who would no way take a fight with him, even on a full camp’s notice, and I know that for a fact. We’re dealing with a freak, we’re dealing with a talent that you don’t see very often.” There is almost something humorous about the contrast between Shalom’s – clearly credible – observations and the unassuming way in which Azim speaks. He is, after all, just 20. But his life is not that of the average 20-year-old. Azim, like his highly-touted, 22-year-old brother Hassan, has been reared to be a champion. We discuss his love of action films – “The Raid, The Raid 2, all the Mission: Impossible films, I’m into DC and Marvel” – but that is the only extracurricular pastime that Azim allows himself. And it has been that way since he was young. Well, even younger. “I didn’t go out much,” he says. “I was always dedicated to boxing. I’d go swimming, cinema, or just chill out at a mate’s house. I didn’t really get to go out and explore, which... You’ve got to make sacrifices in your life. “Even now, I could go out and do a lot of stuff, but I’m just dedicated to my craft, because you can’t switch off in boxing. Footballers can do that because they have a team. All I really do on a weekend off is go for a walk, go round my mates’, or go to the cinema. That’s the same routine I’d done when I was younger. I ain’t gonna change it now, because you don’t wanna go the wrong way. I’ve got a goal to achieve, that’s all I wanna do.” Was there ever a threat of Azim going the ‘wrong way’? “I only went to secondary school for three months, because I was messing about, and my dad actually took me out and made me do home schooling so I could focus on boxing,” Azim says. “I believe if I’d gone to that school... I don’t know what I’d be doing now. My dad did the right thing, I thank my dad a lot for that.” Azim does seem genuinely grateful to be on this path, and to his dad for setting him on it. “He got me where I am today. He noticed I had that fighting spirit. In my family, our cousins and uncles are all fighters. I was meant to be a fighter – I can just feel it, you know?” Shalom agrees. “All he wants to do is fight; he would do it for free, he absolutely loves it. I’ve never met someone as focused as he is. It’s sometimes hard for Shane to calm him down. “It does take a lot for someone to become a star in boxing, there are so many elements that you can get wrong, [but] he’s made some really good decisions early on. His dad knows the game inside-out, and they’ve been preparing for this moment since he was about six years old. It literally is something that they knew was gonna come; they planned meticulously for the last 15 years. “You see tennis stars who’ve been taken around the world since they were young, they were almost bred to be No 1 in their sport. I really believe that’s how Adam has grown up. “He’s also a person who wants to stand for the right things and be the face of British boxing. We think he’s gonna be the one who really becomes synonymous with British boxing over the next five to 10 years.” You’d be a brave man to bet against a monster like this. Read More Built to survive, Dillian Whyte is fighting back and still here Dillian Whyte: ‘I was disappointed to lose to Tyson Fury, but if I lost 10 quid I’d be disappointed’ The Independent’s pound-for-pound boxing rankings Boxxer’s Ben Shalom: ‘I sacrificed my twenties, I sacrificed absolutely everything’ Leigh Wood and Chris Billam-Smith win world titles with victories over familiar foes Leigh Wood given message by trainer Ben Davison after controversial stoppage

PulteGroup beat Wall Street expectations for third-quarter profit on Tuesday, as even at higher prices the demand for

Benjamin Netanyahu said, 'If we don't win now, then Europe is next and you're next. And we have to win'