Adam Frazier and Jorge Mateo each hit an RBI single during Baltimore’s three-run sixth inning, and the Orioles cooled off the Chicago Cubs with a 6-3 win

A treatment for acute migraines has been approved for NHS use for the first time, with experts saying the move could be a “step-change” for thousands of people who suffer from the condition. The National Institute for Health and Care Excellence (Nice) said its final draft guidance on Rimegepant “addresses the high unmet need for treatment options for acute migraine”. Rimegepant, also known as Vydura and made by Pfizer, will be available to adults who have tried at least two triptans – medication usually given to tackle headaches or migraines – but found they did not work well enough. It can also be administered to those who are not able to take triptans or have an intolerance, or patients who have tried nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol. Helen Knight, director of medicines evaluation at Nice, said: “Migraine is a condition described in comments to Nice from carers and people with migraine as an invisible disability that affects all aspects of life including work, education, finances, mental health, social activities and family. “Today’s final draft guidance addresses the high unmet need for treatment options for acute migraine, once again demonstrating our ability to ensure clinically and cost-effective medicines are available to those who need them as quickly as possible.” Rimegepant is taken as a wafer, which dissolves under the tongue and works by stopping the release of a protein around the brain called calcitonin gene-related peptide. In July, the medicine was recommended as an option for preventing episodic migraines in adults who have at least four and fewer than 15 attacks per month if “at least” three other treatments have not worked. This is the first and only Nice-recommended medicine that can help alleviate the misery of acute migraines, and may be considered a step-change in treatment Helen Knight, Nice Under the latest guidance, it will also be used to relieve symptoms of a migraine, which can include pain, nausea and sensitivity to light, but also painless symptoms such as temporary visual disturbances known as “aura”, which Nice said “is not well managed with existing treatments”. The recommendation is expected to benefit about 13,000 people. Ms Knight added: “This is the first and only Nice-recommended medicine that can help alleviate the misery of acute migraines, and may be considered a step-change in treatment.” Migraine is an incredibly misunderstood condition that can have a significant impact on all areas of life, including ability to work, maintain relationships and mental health Robert Music, The Migraine Trust Robert Music, chief executive of The Migraine Trust, said the Nice guidance “provides people with migraine valuable options to help reduce the pain and length of a migraine attack”. “It brings new hope,” he added. “It will especially benefit those who have not found a treatment that works, those who get debilitating side effects – including medicine overuse headache – from them, and those with cardiovascular disease who cannot take existing treatments. “Migraine is an incredibly misunderstood condition that can have a significant impact on all areas of life, including ability to work, maintain relationships and mental health.” Read More NHS winter resilience fund announced by Government NHS reliance on paper notes ‘stopping trusts from realising full potential’ Recession fears as UK economy shrinks by more than expected in shock decline Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live

The New York Yankees, who are waiting for Carlos Rodon and Frankie Montas to return from the injured list, are sidelining another starting pitcher.The New York Yankees starting rotation was supposed to be their strength heading into the 2023 season. But, free agent signing Carlos Rodon has yet t...

Excerpts from an upcoming memoir by The Umbrella Academy actor Elliot Page have revealed the Juno star allegedly received a rape threat from an “acquaintance” at a Los Angeles party – six years before they came out as transgender. Page came out as gay in 2014, but in a section of the book seen and shared by People, the 36-year-old details an incident at a birthday party two months later in which the unnamed individual claimed, “you aren’t gay – that doesn’t exist” and that the Canadian was “just afraid of men”. The chapter, titled “Famous A**hole at Party”, goes on to add the male then reportedly told Page: “I’m going to f*** you to make you realise you aren’t gay.” Despite the threat of ‘corrective rape’ – a hate crime where the abuser seeks to change or ‘cure’ a person’s sexuality, often to heterosexuality – the anonymous actor apparently told Page at the gym, where they saw each other again a few days later, that they “don’t have a problem with gay people, I swear.” “I think you might,” Page replied. Expanding on the situation, Page told People he’s had “some version” of the incident “happen many times throughout my life”. Sign up to our free Indy100 weekly newsletter “A lot of queer and trans people deal with it incessantly. These moments that we often like don’t talk about or we’re supposed to just brush off, when actually it’s very awful. “I put that story in the book because it’s about highlighting the reality, the s*** we deal with and what gets sent to us constantly – particularly in environments that are predominantly cis and heterosexual. “How we navigate that world where you either have more extreme, overt moments like that, or you have the more, like, subtle jokes. [In Hollywood] these are very powerful people – they’re the ones choosing what stories are being told and creating content for people to see all around the world,” they said. Page added that although he’s “purposely” not sharing the name of the individual, the person “will hear about this and know it’s him”, and there were others who saw and heard what happened at the party. Pageboy is published on Tuesday. Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Claudia Goldin, a professor at Harvard University, was awarded the Nobel Prize in economics Monday for her contribution to advancing the understanding of women in the labor market

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