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bit.bio Unveils Cell Therapy Pipeline, Including Lead Candidate for Acute Liver Failure, and Significantly Expands Scientific Advisory Board with Global Experts in Cell Therapy
bit.bio Unveils Cell Therapy Pipeline, Including Lead Candidate for Acute Liver Failure, and Significantly Expands Scientific Advisory Board with Global Experts in Cell Therapy
CAMBRIDGE, UK--(BUSINESS WIRE)--Nov 8, 2023--
2023-11-08 16:00
UK Home Secretary Suella Braverman wows some Conservatives and alarms others with hardline stance
UK Home Secretary Suella Braverman wows some Conservatives and alarms others with hardline stance
Britain’s Home Secretary Suella Braverman has railed against unauthorized migrants, human-rights laws and “woke” critics of her hardline policies at the Conservative Party's annual conference
2023-10-04 00:24
UK Holds Off on Big Cut to Planned Debt Sales, Weighing on Gilts
UK Holds Off on Big Cut to Planned Debt Sales, Weighing on Gilts
The UK kept its bond issuance plans little changed for the current fiscal year, surprising a market that
2023-11-22 22:31
'Only Murders in the Building' Season 3: Here's all the lyrics to the 'Pickwick Triplets' song
'Only Murders in the Building' Season 3: Here's all the lyrics to the 'Pickwick Triplets' song
Which of the Pickwick Triplets did it? Who of the crew could commit this crime?
2023-09-20 00:00
Mauricio Pochettino shares Chelsea fans’ frustrations after goalless stalemate
Mauricio Pochettino shares Chelsea fans’ frustrations after goalless stalemate
Mauricio Pochettino said he cannot control Chelsea fans’ reactions after a section of the away support appeared to boo Ben Chilwell at the end of the team’s drab 0-0 draw at Bournemouth. Chilwell was a second-half substitute at the Vitality Stadium but failed to substantially alter the team’s fortunes as they laboured in vain to break the hosts down in wet conditions. Pochettino named three outfield players aged 19 or under on the bench as well as two goalkeepers as the club’s injury crisis continued to deepen. Marc Cucurella and Noni Madueke were fresh additions to the absentee list at Bournemouth, taking the total number of players unavailable to the manager to 12. Chelsea threatened only sporadically, looking to use the channels to attack but only rarely finding a final ball to open up the home side. Raheem Sterling hit the crossbar with a fiercely hit free-kick whilst Nicolas Jackson also struck the woodwork in the first half but it was Robert Sanchez who was called upon to make the save of the game when he spread himself low at the feet of Dango Ouattara as the striker bore down on his goal. It leaves Pochettino’s side 14th in the table with just one win from five matches, and with an uneasy sense that last season’s problems in front of goal are a long way from being fixed. And some fans seemed to vent their frustrations when England international Chilwell went over to applaud the away end at full-time. “What can we do?” said Pochettino. “For me, I have nothing to say. The fans can do whatever they want. “We know what we need to do, we are strong in our belief. We have 12 injured and today we had three or four young guys and two keepers on the bench. “I’m going to cry? I’m going to complain? To who? I need to accept this, the challenge and keep being positive.” The Argentinian continued: “Bournemouth is a good team, they are going to compete. Every team is going to compete and be difficult. “But these are the circumstances we need to accept and be positive, patient. We are not going to change in the way we do things. “What can I do? Only to keep believing. If you say to me we have today all of our players, all of our signings, no injuries, and maybe we cannot win this game? Then maybe I can tell you we need to see (it) in a different way. But we cannot lie to the people.” I’m going to cry? I’m going to complain? To who? I need to accept this, the challenge and keep being positive Mauricio Pochettino Chelsea have failed to score in their last two Premier League outings and have won just twice in the league since March, at the Vitality Stadium late last season when Bournemouth were already safe and last month at home to newly-promoted Luton. Pochettino was asked whether he was sympathetic to the reaction of those supporters that booed the players off. “What I can tell the fans is the circumstance that we cannot change,” he said. “The reality that we cannot change. We have too many players (injured). We’re a team that would be strong if we are together. “Even Manchester City, Arsenal, when they have all the squad fit, they can compete for everything. Why is it different for us? It’s because of what? We don’t have all the squad available from the beginning of the season.” Bournemouth boss Andoni Iraola reflected on a performance that showed promise despite the winless run at the start of his tenure now stretching to five league matches. “I’m really happy with the performance,” he said. “The game was quite level. Both teams had their chances. Overall, we had very good individual performances and finished the game even better. “There were moments later on where we thought the game could be ours.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Ryan Fox wins BMW PGA Championship at Wentworth after Ludvig Aberg fades End of the road for Jason Roy? What England squad surprise means for World Cup Mason Greenwood comes off the bench to help Getafe get a home win
2023-09-18 00:47
Jimmy Hoffa disappearance anniversary: What happened to long-lost union leader presumed murdered by the mob?
Jimmy Hoffa disappearance anniversary: What happened to long-lost union leader presumed murdered by the mob?
Jimmy Hoffa, the legendary American union organiser, disappeared from a parking lot outside of the Machus Red Fox restaurant in Bloomfield Township, Detroit, 48 years ago on Saturday 30 July 1975. Presumed dead since the same date in 1982, his body has never been found, no one has ever been charged and the case remains unsolved. Hoffa, 62, was last heard from at around 2.15pm that afternoon, calling his wife at their home in Lake Orion and a friend, Louis Linteau, at his office from a public payphone, griping that the two gentlemen he was supposed to be meeting for lunch had failed to show up. He was subsequently spotted talking to several other men nearby before being driven away in a maroon car that one eyewitness, a truck driver, told investigators could have been a Lincoln or maybe a Mercury Marquis. It might as well have been a hearse, for all the difference it made, for James Riddle Hoffa would never be seen again. His own vehicle, a green Pontiac Grand Ville, stood abandoned at the scene, just where he had left it. Long assumed to have been the victim of a mob hit, the visionary general president of the International Brotherhood of Teamsters (IBT) – who dramatically expanded the union’s reach, influence and coffers between 1957 and 1971, before being brought down by scandal – certainly had more than his fair share of powerful enemies and shady associates. Hoffa’s story – or, at least, versions of it – has frequently been told over the past half-century, often fictionalised through characters loosely based upon him in movies like Sergio Leone’s Once Upon a Time in America (1984) or more directly in Danny DeVito’s biopic Hoffa (1992) starring Jack Nicholson, James Ellroy’s Underworld USA novel sequence or Martin Scorcese’s recent The Irishman (2019) in which Al Pacino played the doomed labour leader. But none of those projects have come close to cracking one of the most enduring true crime mysteries in the history of American public life. What really happened to Jimmy Hoffa? Now that is a riddle. Born on Valentine’s Day 1913 in Brazil, Indiana, Hoffa’s Pennsylvania Dutch father John was a coal miner who passed away from lung disease in 1920 when his son was just seven years old, prompting the family to relocate to Detroit, Michigan, soon to become the epicentre of the mighty American auto industry. Realising he would need to grow up fast to support his mother, Hoffa left school at 14 to work as a stock boy for a grocery chain, where he soon took exception to the inadequate wages he received, the perilous terms of his employment and the inequality he saw all around him, which would only worsen in the aftermath of the Wall Street Crash of 1929 with the coming of the Great Depression. Having learned to stand up for himself against workplace injustice, Hoffa quit in 1932 to work as a professional organiser with the Local 299 chapter of the Teamsters union, representing Detroit’s truck drivers and warehouse operatives. As the organisation grew over the course of a combative decade, consolidating its power first locally, then regionally and finally nationally, Hoffa met the Polish girl who would become his wife, Josephine Poszywak, during a strike undertaken by non-unionised laundry workers in early 1937. They married that September. Hoffa’s growing reputation and networking smarts saw him named chairman of the Central States Drivers Council in 1940, president of the Michigan Conference of Teamsters in 1942 and then president of Local 299 by 1946, all without moving so much as a single truck himself. As a labour stalwart, Hoffa secured a draft deferment when the United States entered the Second World War by successfully arguing he would be of far greater service to his country organising industry at home than he might be deployed as a grunt abroad. That also meant he was well positioned to reap the spoils of the American economic boom of the Truman years. By 1952, he was appointed international vice president of the IBT, serving as deputy to Dave Beck, who was himself succeeding Daniel Tobin, who had led the union since way back in 1907. The IBT relocated its headquarters from Indianapolis to Washington, DC, three years later in order to be better placed to lobby Congress for its interests. It had never been more powerful. Then, in 1957, Beck was indicted, convicted and jailed on fraud charges after being hauled before John McClellan’s Senate Select Committee on Improper Activities in the Labour or Management Field. Hoffa was voted in as his successor as general president at the IBT’s convention in Miami Beach, Florida, that October. However, Hoffa’s profile within the labour movement had inevitably increased his exposure to organised crime and he had been arrested earlier that year for allegedly attempting to bribe a McClellan Committee aide, prompting the AFL-CIO to expel the Teamsters from its ranks in passionate opposition to his appointment. The air of notoriety surrounding Hoffa caught the attention of mob-busting US attorney general Robert F Kennedy during his brother’s presidency in the early 1960s and would see much of the organiser’s energies eaten up by legal scraps for much of that decade. He was indicted for jury tampering in Tennessee in May 1963 after again being accused of attempted bribery and was convicted the following March, sentenced to eight years in prison and a $10,000 fine. Four months later, while out on bail for the first offence, he was convicted at a second trial in Chicago, Illinois, on one count of conspiracy and three of mail and wire fraud for improper use of the Teamsters’ pension fund. This time he was sentenced to five years behind bars. After spending three years unsuccessfully appealing those convictions – while simultaneously expanding the union and bringing almost all on-road North American truck drivers together under one National Master Freight Agreement – Hoffa was sent to Lewisburg Federal Penitentiary in Pennsylvania on 7 March 1967 to serve a 13-year aggregate sentence. Despite the disgrace, he refused to resign and went on operating as IBT boss from Lewisburg, remaining in the role until 19 June 1971, when he was replaced by Frank Fitzsimmons, with whom he had a long association dating back to their Detroit days. Hoffa was released from prison on 23 December that year, having served fewer than five of his 13 years after Richard Nixon commuted his sentence on the condition that he refrain from engaging in union activity until 6 March 1980, a stipulation he was bitterly opposed to and battled in court in the hope of being able to wrestle back the Teamster’s presidency, unmoved to consider retirement by the generous pension settlement the organisation had handed him. The Mafia were among those opposed to his comeback ambitions, and one of their enforcers was Anthony “Tony Pro” Provenzano, a capo in New York City’s Genovese crime family with whom Hoffa had once been close but seemingly fallen out with while both men were incarcerated at Lewisburg. Provenzano is one of the men Hoffa is supposed to have been dining with at the Machus Red Fox on the day he vanished. The other was Anthony “Tony Jack” Giacalone, a local heavy who may have been dispatched as a mediator to oversee Hoffa’s appeal for support to Provenzano. Neither would admit to having seen the labour veteran in Bloomfield Township that day and both seemingly had credible alibis. What is known is that the car in which Hoffa is most likely to have been spirited away – a 1975 Mercury Marquis Brougham, after all – belonged to Giacalone’s son Joseph, who had lent it to one Charles “Chuckie” O’Brien, a Hoffa family friend. O’Brien may have been engaged to collect the old man in order to encourage a false sense of security. His fingerprints would later be found on a 7-Up bottle in Hoffa’s Pontiac, although he continued to deny any involvement until his death in 2020. When investigators examined the Mercury on 21 August, police dogs positively identified Hoffa’s scent in its upholstery, strongly suggesting he had ridden in it at least once. Later, in 2001, the advance of DNA technology enabled officers to locate a strand of his hair in the same car, although, again, that was not sufficient to trace it to a specific date. After years of federal investigation had resulted in 16,000 pages of documents spread over 70 volumes but no outcome, leaving Hoffa’s wife Josephine to pass away in 1980 without answers, the FBI’s opinion on what had happened would be outlined by Arthur Sloane in his book Hoffa (1991). In it, Sloane suggested the official verdict was that Northeastern Pennsylvania mob boss Russell Bufalino had ordered the hit and dispatched Thomas Andretta and the brothers Salvatore “Sally Bugs” and Gabriel Briguglio, alongside O’Brien, to carry it out. The quartet then either killed Hoffa inside the vehicle or drove him on to an unspecified location and executed him there, perhaps cremating his body to prevent its rediscovery. That broad outline was effectively confirmed on 16 June 2006 when The Detroit Free Press published the entire 56-page “Hoffex Memo”, an FBI dossier dating from January 1976 in which the bureau expressed its suspicions in writing, arguing the gangsters were concerned that a reinstated Hoffa might interfere with their control of the Teamster’s pension fund or even be persuaded to testify against them. There are numerous quibbles with that theory, however. Experts often argue that Hoffa was too high-profile a target for the mob to assassinate in such a public manner and that his hopes of returning to the leadership of the union amounted to little more than a pipedream by 1975, his name too tarnished to represent a serious threat. According to Sloane, former US prosecuting attorney Keith Corbett also believed that O’Brien was too unreliable to have played a part and that Vito “Billy” Giacalone, the younger brother of Tony Jack, was more likely to have been the fourth man. A completely fresh theory appeared in 2004 with the publication of Charles Brandt’s book I Heard You Paint Houses, the basis for Scorsese’s The Irishman, in which the author argues that hitman Frank Sheeran did the deed in an empty house in Detroit after Hoffa had been delivered into his clutches, the subject having confessed as much in old age. Bloodstains found on floorboards at the scene did not match Hoffa’s DNA, however, and it is often thought unlikely, as was the case with O’Brien, that an outsider might be trusted with such a delicate assignment by the notoriously tribal Italian-American syndicate. Another infamous mob killer, Richard “The Iceman” Kuklinski, claimed in his own 2006 memoir that he was responsible, having been paid the princely sum of $40,000 to whack Hoffa. Kuklinski claimed he drove the body to a New Jersey junkyard, sealed it inside a 50-gallon oil drum and set it on fire, later digging up the charred cadaver and placing it in the trunk of a car that was duly sold for scrap metal. That has likewise never been substantiated. As to the final resting place of Hoffa’s remains, multiple sites have been inspected over the decades without yielding a result, from the now-demolished Giants Stadium in East Rutherford (a tip-off hitman Donald “Tony the Greek” Frankos offered in a 1989 Playboy interview) to a landfill beneath the Pulaski Skyway in Jersey City and even the Renaissance Building in downtown Detroit, now the 73-storey home of General Motors. A farmer’s field, a swimming pool and a suburban driveway in Michigan have all been proposed and discarded while the wildest speculations imagine the missing man tossed from a plane by corrupt federal marshals into the Great Lakes (a theory courtesy of Hoffa bodyguard Joseph Franco, who had a book to sell) or ground up and disposed of in one of the quieter swamps of the Florida Everglades, an idea pitched to the Senate by self-described murderer Charles Allen in 1982. Sadly, we may never know the truth about how Jimmy Hoffa, at one time one of the most famous faces in America, came to vanish into thin air, blown away on the breeze like an old parking ticket, never to be seen again. Read More FBI say no sign of Jimmy Hoffa’s body under New Jersey bridge Events in the disappearance of former Teamsters head Jimmy Hoffa From serious to scurrilous, some of the many Jimmy Hoffa theories
2023-07-28 15:05
Sunak’s Tories Hold Ex-PM Boris Johnson’s Seat in Morale Boost
Sunak’s Tories Hold Ex-PM Boris Johnson’s Seat in Morale Boost
Rishi Sunak’s Conservatives unexpectedly held onto Boris Johnson’s old parliamentary seat in a special election, a major boost
2023-07-21 09:51
Steep drop puts S.Africa inflation back within target range
Steep drop puts S.Africa inflation back within target range
South African inflation dropped to the lowest level in 20 months in June, slipping back within the central bank's target...
2023-07-19 17:22
Women's World Cup Final: All the best memes and reactions as Lionesses face Spain
Women's World Cup Final: All the best memes and reactions as Lionesses face Spain
Sarina Wiegman named an unchanged starting line-up for England’s first-ever World Cup final to face Spain in Sydney. Ella Toone retained her place, while Lauren James returned after serving a two-match suspension and began on the bench. Ballon d’Or winner Alexia Putellas was named amongst the substitutes for Jorge Vilda’s Spain, who also made it to a first final in their history, while Salma Paralluelo earned the start. The 19-year-old has scored twice in this World Cup, including the extra-time winner against the Netherlands in the quarter-final. England and Arsenal footballer Beth Mead, who missed out on a spot in the Lionesses squad due to an anterior cruciate ligament injury, has told the BBC she is “not surprised” they are in the World Cup final. Mead told BBC Breakfast: “I’ve been super-proud of them and what they have achieved so far. Obviously they weren’t all guns firing in the group stages, but now they have grown into the tournament, a great semi-final against Australia and hopefully they peak today. “I’m not surprised where they are, I know the quality we have in the squad and the direction that Sarina (Wiegman) is putting us in.” Social media is already awash with memes and good luck messages to the players. Here are the best of reactions as the match played out in real-time. Additional reporting by PA. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.
2023-08-20 17:12
MLB rumors: Bellinger extension, Rays target a pitcher, Dodgers struggling infielder
MLB rumors: Bellinger extension, Rays target a pitcher, Dodgers struggling infielder
The latest MLB rumors feature a Dodgers prospect that is struggling, a possible Rays move, and the fate on a Cubs-Cody Bellinger extension.Dodgers may send Miguel Vargas downFabian Ardaya of The Athletic (subscription required) noted that Dodgers manager Dave Roberts told reporters Miguel Vargas...
2023-07-09 23:17
Why did KSI hilariously troll iShowSpeed? Rapper claims streamer 'just stinks'
Why did KSI hilariously troll iShowSpeed? Rapper claims streamer 'just stinks'
Previously, Speed challenged KSI to a boxing match, confidently claiming that he could defeat him in the ring
2023-06-05 12:29
Jake Paul takes rivalry with KSI to a personal level, leaks private messages
Jake Paul takes rivalry with KSI to a personal level, leaks private messages
Before waiting for 'The Nightmare' to respond, Paul went on to make fun of his bitter enemy's receding hairline
2023-09-25 15:51