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St. Louis Cardinals general manager John Mozeliak is busy working the phones at the MLB trade deadline. So, who is next to go?The Cardinals have already traded away key players like Jordan Montgomery and Jordan Hicks -- both of whom are technically rentals -- for five prospects. FanSided's ...

Harry Kane bagged a hat-trick as Bayern Munich maintained their unbeaten run in the Bundesliga after hammering Bochum 7-0. The hosts ran riot with the England captain scoring just minutes after Eric Maxim Choupo-Moting’s opener and goals from Matthijs de Ligt and Leroy Sane gave them a 4-0 lead at half-time. Their dominance continued after the break as Kane scored from the spot and assisted Mathys Tel before earning his first hat-trick for Bayern with minutes to go. Kane’s excellent start with Bayern means he has now scored seven goals in five league matches as the defending Bundesliga champions sit top of the table. The hosts threatened early as Manuel Riemann saved from Choupo-Moting in the first minute, but the forward made no mistake the second time after Kingsley Coman squared the ball to him for an easy tap-in just four minutes into the match. Kane doubled their lead in the 13th minute with a neat finish into the bottom corner and soon had a chance to earn his second but blasted the ball over the bar. Sven Ulreich was called into action to make a diving save from Christopher Antwi-Adjei, but Bayern quickly had their third in the 29th minute after Joshua Kimmich’s corner found De Ligt, who thumped a header into the corner. Another great chance saw Kane thread the ball through to Choupo-Moting, who was denied by Riemann, but the England captain then hit a great pass for Sane, who burst down the centre of the pitch to tuck the ball into the far bottom corner seven minutes before half-time. Riemann made two crucial saves late in the first half to deny Kane and Coman in quick succession, but the goals kept flowing for Bayern after the break. Ivan Ordets conceded a penalty after handling the ball in the box and Kane earned his brace in the 54th minute with a low spot-kick beating Riemann. Coman kept the pressure on, going close a few minutes later with a curling effort clipping the post and Frans Kratzig smashed an effort towards goal forcing Riemann to tip the ball over the bar, but Bayern extended their lead in the 81st minute when Kane found Tel who fired the ball into the far corner. The former Tottenham man then earned his hat-trick with two minutes of normal time left, getting on the end of a ball from Sane to slot the ball in at the near post. PA Read More Harry Kane happy with Bayern Munich start in Europe – Thursday’s sporting social Classy Kane and brilliant Bellingham – England duo making waves in Europe Bruno Fernandes tells Andre Onana to stop blaming himself for Man Utd defeat Devastated Andre Onana takes responsibility for Man Utd’s defeat in Munich Football transfer news: Tottenham have first refusal when Harry Kane leaves Bayern How Harry Kane unshackled Bayern Munich with a classic move from his Tottenham days

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Scientists have developed an artificial intelligence (AI) tool that can classify four subtypes of Parkinson’s disease with up to 95% accuracy. Researchers from the Francis Crick Institute and the UCL Queen Square Institute of Neurology in London “trained” a computer program to recognise the subtypes of the condition using images of stem cells from patients. The team said their work, published in the journal Nature Machine Intelligence, could pave the way for personalised medicine and targeted drug discovery. Sonia Gandhi, assistant research director and group leader of the Neurodegeneration Biology Laboratory at the Crick, said: “We understand many of the processes that are causing Parkinson’s in people’s brains. The hope is that one day this could lead to fundamental changes in how we deliver personalised medicine Sonia Gandhi, Francis Crick Institute “But, while they are alive, we have no way of knowing which mechanism is happening, and therefore can’t give precise treatments. “We don’t currently have treatments which make a huge difference in the progression of Parkinson’s disease. “Using a model of the patient’s own neurons, and combining this with large numbers of images, we generated an algorithm to classify certain subtypes – a powerful approach that could open the door to identifying disease subtypes in life. “Taking this one step further, our platform would allow us to first test drugs in stem cell models, and predict whether a patient’s brain cells would be likely to respond to a drug, before enrolling into clinical trials. “The hope is that one day this could lead to fundamental changes in how we deliver personalised medicine.” Parkinson’s is a condition in which parts of the brain become progressively damaged over many years. Symptoms include involuntary shaking of particular parts of the body, slow movement, and stiff and inflexible muscles. But there is also a wide range of other physical and psychological symptoms such as depression and anxiety, problems sleeping, and memory problems. These vary from person to person due to differences in the underlying mechanisms causing the disease. The researchers said that until now, there was no way to accurately differentiate Parkinson’s subtypes. It means people are given nonspecific diagnoses and do not always have access to targeted treatments, support or care, the team added. For the study, the researchers generated stem cells, which have the ability to develop into specialised cell types in the body, from patients’ own cells. The team then used those cells to chemically create four different subtypes of Parkinson’s: two involving pathways leading to toxic build-up of a protein called alpha-synuclein and two involving pathways associated with dysfunctional mitochondria, the cell’s battery packs. Working with the British technology company Faculty AI, the team developed machine-learning algorithms which were able to accurately predict the Parkinson’s subtype when presented with images it had not seen before. James Evans, a PhD student at the Crick and UCL, and first co-author of the study, said: “Now that we use more advanced image techniques, we generate vast quantities of data, much of which is discarded when we manually select a few features of interest. “Using AI in this study enabled us to evaluate a larger number of cell features, and assess the importance of these features in discerning (the) disease subtype. “Using deep learning, we were able to extract much more information from our images than with conventional image analysis. “We now hope to expand this approach to understand how these cellular mechanisms contribute to other subtypes of Parkinson’s.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Oxford scientists find no evidence to suggest Facebook not good for wellbeing Many adults would struggle to understand video-sharing platforms’ rules – Ofcom Ozzy Osbourne PlayStation tweet which failed to reveal link to Sony banned

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A bisexual OnlyFans model has revealed that she only sleeps with women out of respect for her fiancé – but insists she’s not being unfaithful. Karlee Grey, who has 1.65 million followers across Twitter and Instagram (@foreverkarleegrey ) has made a small fortune from the adult site, pulling in over six figures a year. And she’s made it a rule to only make content solo or with other women. The 29-year-old, who has been with her 33-year-old male fiancé, [not named at case study’s request] for six years, actually attributes her racy career to creating a healthier relationship between them. Sign up to our free Indy100 weekly newsletter Her partner even helps out with the model’s OnlyFans page since she joined in 2019, often taking photos and videos of her. "I only work with women and he's completely fine with that," Karlee told Jam Prime. "If anything, it's elevated us and made us explore a little bit more. "He even helps me sometimes with point-of-view filming, and he's my photographer, he takes my photos and edits a lot of my work – he's part of my team.” Karlee, who lives in California, US, says the pair avoid any jealous feelings about her work by making more time to get intimate together. For the couple, the conversation about sleeping solely with women happened naturally after her feelings for him deepened. She said: "There wasn't like a specific way that it was navigated, I personally didn't want to share my body with another male anymore. "Once I started loving someone so deeply, I just felt like I couldn't do that but with women, I'm always going to be attracted to them. "I don't know if I would ever necessarily date women relationship-wise but I'm always going to be sexually attracted and he's aware of that. "He says 'if you already don't want to do it with men then I don't mind if you do it with women' – it's sort of an outlet." For Karlee, who wants to make sure her fiancé is included in the fun, her work is a great way to invite other women to “share” him with her occasionally. And although the pair are careful not to bring women into their emotional relationship, once a year they “have a fun experience” with a third person. Despite her fun-loving demeanour, Karlee, who has been in the sex industry since 2014, is meticulous about who she works with, not only for her safety but also her pleasure. She added: "I personally love women, and I don't want to feel like I'm working with somebody that's not actually enjoying this. "I want to feel like if the cameras weren't on, you would still want to do it –I've only had a couple of bad experiences, mainly because I always choose women who I know really love women.” Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Tottenham began life without Harry Kane with an entertaining 2-2 draw at Brentford in the Premier League on Sunday