Here's the full list of talent working the 2022 Overwatch League season.

The Milwaukee Brewers rode a massive 12-run second inning to a 16-1 victory over the Miami Marlins on Friday that clinched a...

With Chelsea midfielder Mason Mount heading to Manchester United in a move potentially worth £60m, reinforcements will be required at Stamford Bridge. Gabri Veiga is one of five players the club could look to sign this summer.

Adin Ross faced criticism for lying to his mother and making her 'freak out' after he lost $4 million while gambling

SAN SALVADOR El Salvador has deployed at least 5,000 soldiers and 500 police to surround a town in

Pope Francis was set to be discharged from Rome's Gemelli hospital Friday where the 86-year-old was recovering from abdominal surgery.

Fans of 'The Idol' nickname Sam Levinson the 'king of unresolved plots' and criticize them for spoiling the series ending

Gregg Berhalter admitted he has not spoken to US men’s national team player Gio Reyna since the 2022 World Cup, explaining “there’s work to do” to repair the relationship.

Saudi Aramco is weighing exports of liquefied natural gas instead of blue hydrogen, as talks with potential buyers

Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Napoli striker Victor Osimhen is reserving “the right to take legal action” against his own club after his team posted a bizarre video to TikTok seemingly mocking the player. The odd video comes after Osimhen helped the Italian team secure a first league title, the club’s first in three decades. Despite Osimhen singlehandedly bolstering Napoli with 31 goals across all competitions, he became the target of a strange, now-deleted video, shared to the Serie A club’s official TikTok account. Osimhen’s agent Roberto Calenda issued a statement on Tuesday night about the incident. He wrote on X, formerly known as Twitter: “What happened today on Napoli’s official profile on the TikTok platform is not acceptable. A video mocking Victor was first made public and then, but now belatedly, deleted. “A serious fact that causes very serious damage to the player and adds to the treatment that the boy is suffering in the last period between media trials and fake news.” Calenda added: “We reserve the right to take legal action and any useful initiative to protect Victor”. The video featured a clip of the striker’s penalty miss from their match against Bologna on Sunday, with an odd, sped-up voice dubbed over the top. While the original was deleted, recorded versions of it appeared on Twitter/X soon after - while Osimhen himself appears to have deleted every Instagram post on his account which featured a Napoli shirt. The strange social media clip comes after there appeared to be tension between Osimhen and Napoli manager Rudi Garcia during the game. The 24-year-old Nigerian striker was seen berating Garcia as he was substituted off with four minutes remaining of the goalless draw. The bizarre social media scrap comes after Osimhen, who captured the interest of Manchester United this summer, did not sign a new contract with the Italian team. Osimhen’s current deal runs through to the summer of 2025. PA Read More Jenni Hermoso among three Spain World Cup winners shortlisted for top FIFA award Kalvin Phillips must seize rare chance to move away from being Man City’s decorated substitute This England team aren’t used to losing – the Lionesses must learn to kick the habit quickly Schoolboy almost dies from swallowing magnets for TikTok challenge Woman shares honest review of New York City apartment TikTok mom slammed after making 5-year-old son run in 104 degree heat

Players have a limited time to earn the rewards for the Unova Challenge during Pokémon GO’s Evolving Stars event. The event began Wednesday at 10 a.m. and ends on Tuesday, Oct. 11.