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Using existing drugs to treat cervical cancer before standard treatment could lead to a 35% reduction in the risk of relapse or death, a new study suggests. Researchers from the UCL Cancer Institute and UCLH looked into whether a short course of induction chemotherapy (IC), where a drug is used to destroy as many cancer cells as possible, before chemoradiation (CRT), could help with this. Here’s everything you need to know about the findings… What is cervical cancer? According to the NHS website, cervical cancer is a type of cancer found anywhere near the cervix – the opening between the vagina and the womb (uterus), which is also known as the neck of the womb. Most cervical cancers grow very slowly and are caused by an infection from specific types of human papillomavirus (HPV) and mostly affect women under the age of 45. According to Jo’s Cervical Cancer Trust, symptoms include vaginal bleeding that is unusual to you, changes to vaginal discharge, discomfort during sex and pain in your lower back or pelvis. Changes to cells can be spotted by a cervical screening, and then treated before they turn into cancer. There are around 3,200 new cases every year in the UK, with the five-year survival rate being around 70%, according to Cancer Research UK. CRT has been the standard treatment for cervical cancer patients since 1999, but even though there have been overall significant developments in radiation therapy techniques, up to 30% of people experience their cancer coming back. What did the research involve? Over a 10-year period, 500 patients who had been diagnosed with cervical cancer – that was large enough to see without a microscope but hadn’t spread to other parts of the body – took part in the Interlace trial at hospitals in the UK, Mexico, India, Italy and Brazil. Researchers looked into whether a short course of IC before CRT could reduce rates of relapse and death. What results were found? After five years, researchers discovered that 80% of the people who received a combination of chemotherapy and radiotherapy were alive, whilst 73% had not seen their cancer return or spread. A major benefit, according to researchers, is that it can be incorporated into standard of care treatment relatively quickly, because cheap, accessible and already-approved ingredients such as carboplatin and paclitaxel are needed for IC. “Our trial shows that this short course of additional chemotherapy delivered immediately before the standard CRT can reduce the risk of the cancer returning or death by 35%,” said Dr Mary McCormack, lead investigator of the trial from UCL Cancer Institute and UCLH. “This is the biggest improvement in outcome in this disease in over 20 years. “I’m incredibly proud of all the patients who participated in the trial; their contribution has allowed us to gather the evidence needed to improve treatment of cervical cancer patients everywhere. “We couldn’t have done this without the generous support of Cancer Research UK.” Why is the research important? Dr Iain Foulkes, executive director of research and innovation at Cancer Research UK, said: “Timing is everything when you’re treating cancer. The simple act of adding induction chemotherapy to the start of chemoradiation treatment for cervical cancer has delivered remarkable results in this trial. “A growing body of evidence is showing the value of additional rounds of chemotherapy before other treatments like surgery and radiotherapy in several other cancers. “Not only can it reduce the chances of cancer coming back, it can be delivered quickly using drugs already available worldwide. “We’re excited for the improvements this trial could bring to cervical cancer treatment and hope short courses of induction chemotherapy will be rapidly adopted in the clinic.”

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SAN JOSE, Calif.--(BUSINESS WIRE)--Nov 9, 2023--

Crystal Palace boss Roy Hodgson admitted he “feels sorry” for opponents Newcastle, who could lose summer signing Sandro Tonali to a lengthy ban depending on the outcome of an investigation into alleged betting offences. Eddie Howe on Friday confirmed his midfielder, who joined in a £55million move from AC Milan this summer, would be available for Saturday’s contest, where the injury-plagued Eagles will be boosted by the return of several key players. While Hodgson initially claimed not to have “any reaction at all” to the news Tonali could feature, he subsequently expressed some empathy surrounding the situation still unfolding at St James’ Park. He said: “It’s nothing to do with me. One way or the other, I feel sorry for him, I feel sorry for Newcastle facing this situation. “It must be a bitter blow to sign somebody that you believe in as much as they obviously do believe in Sandro Tonali, and then to find after paying a lot of money that maybe you can’t use him for a long period of time. “That must be a very difficult situation for Eddie Howe and [sporting director] Dan Ashworth, for the club to deal with. But it doesn’t affect us one way or the other, if Newcastle want to play him then good luck to him. If they decide they don’t, then that’s their decision.” Howe has already vowed that Tonali, who is subject to investigation by the Italian Prosecutor’s Office and Italian Football Federation (FIGC) in relation to illegal betting activity, has a future at his club. Plans are in place for the Premier League to withdraw gambling sponsorship from the front of teams’ matchday shirts from the start of the 2026-2027 season, though it is understood betting companies will still be allowed to advertise on sleeves. The Eagles previously had a gambling company, W88, as their shirt-front sponsor but signed a multi-year deal with car company Cinch ahead of last season. Hodgson’s men still wear a betting brand on their sleeves, however, after the club announced a deal with Asian sportsbooks brand Kaiyun Sports in May. Hodgson said: “We know that gambling is a problem in our society, and we don’t really help it in sport because we promote betting. “I think it’s a problem that we should take more seriously perhaps than we have done. We’ve certainly made big strides with drugs, with alcohol, maybe gambling and betting will be the next subject to take on because I’m not just talking football, now I’m talking about society in general. Footballers still sometimes get caught up in it, and unfortunately for them when they do get caught up for it the punishments are very strict Roy Hodgson “So it’s not surprising with all the problems that gambling does bring to our society that footballers still sometimes get caught up in it, and unfortunately for them when they do the punishments are very strict.” Perhaps no one welcomed the international break as much as Hodgson, who had two more players, Jeffrey Schlupp and Jairo Riedewald, forced off in their goalless draw with Nottingham Forest last time out. The Palace boss should see midfield duo Jefferson Lerma and Cheick Doucoure return to his matchday squad this weekend alongside 19-year-old Brazilian summer signing Matheus Franca, healthy for the first time this season, though it is still too soon for Schlupp and long-term casualties Michael Olise and Eberechi Eze. Defender James Tomkins is now out with a calf injury. Read More Mikel Arteta showing he is ‘one of the best’ – Mauricio Pochettino New state-of-the-art Bradford venue can help take barriers down, says ECB chief Pep Guardiola believes both Erling Haaland and Lionel Messi deserve Ballon d’Or Tottenham reveal Rodrigo Bentancur injury update as key midfielder nears return Victor Lindelof ready despite ‘exhausting’ experience with Sweden – Erik ten Hag Jack Harrison says working with Frank Lampard and Marcelo Bielsa has boosted him

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