Alan Browne has challenged the Republic of Ireland to spoil the Netherlands’ Euro 2024 party as they look to end a disappointing campaign on a high. The curtain will fall on Ireland’s dismal attempt to make next summer’s finals at the Johan Cruyff Arena in Amsterdam, with automatic qualification long beyond them and only six points from home and away victories over Group B minnows Gibraltar to show for their efforts to date. There will be little more than pride at stake for Stephen Kenny’s men on a night when victory would assure the Dutch of their ticket to Germany alongside leaders France, but Preston midfielder Browne is determined to make them sweat. Asked if the chance to put the champagne on ice provided added motivation, the 28-year-old said: “It’s not so much about spoiling their party, but we want to come here and win. “The lads will be aware that we can play with a bit of freedom, it’s a bit of a free hit for us – which is obviously disappointing to say as a player, but that’s the way it is. “We want to win the game and spoil their party to an extent, but it’s not a vendetta against them, it’s just as a professional you want to win every game that you play in, and especially at the highest level against one of the best teams in the world, you want to go out and beat them. “It would mean an awful lot for us to get that result.” The game seems likely to be the penultimate fixture of Kenny’s reign – his contract is due to expire after Tuesday night’s friendly against New Zealand in Dublin and the clamour for change after an overhaul which has significantly reduced the age profile of the squad, but yielded only six wins in 28 competitive outings, has grown in recent months. However Kenny, who will have striker Evan Ferguson at his disposal, but not the injured Chiedozie Ogbene, remained bullish as he surveyed the task ahead. He said: “It’s a fantastic game against Holland. In the history of Irish football, all the great Irish teams of the past, some legendary players, it’s been elusive, the number of big away victories in that period. “Obviously there have been victories in tournaments, but in terms of qualifiers, beating the major countries has proved elusive, even for the best teams. “For us it’s a massive challenge to play Holland on the night they can qualify in Amsterdam. It’s a huge, huge challenge and one we must embrace and be positive about.” Browne for one has enhanced his reputation under Kenny’s watch, scoring important goals against Serbia, Belgium, Scotland and Norway, and he remains convinced that, while it may not be borne out by results, progress has been made. He said: “I’ve seen a lot of stuff in the media, a lot of criticism, and rightly so in terms of results. It’s been a tough one. “The group we got, we knew it was an uphill battle right from the start. The teams we got, we were really unfortunate. Any other team would be unfortunate with it as well. In terms of performances, I think we have come a long way Republic of Ireland midfielder Alan Browne “But that’s what you are up against, the best teams in the world, if you want to succeed you’ve got to beat them. “In terms of performances, I think we have come a long way. “Certainly since I first came in, in terms of team performances, we have definitely come a long way, we know that as players and staff. We have been in it together and just come up short in terms of results.” Read More Stephen Kenny’s last dance? 5 talking points as the Republic face Netherlands Golden Boy award recognises Jude Bellingham’s irrepressible rise at Real Madrid Fine finish hands Nicolai Hojgaard two-shot lead at halfway stage in Dubai Exeter captain Poppy Leitch hoping for more progress during inaugural PWR season Street Child Cricket World Cup gives youngsters chance to shine Wales v Armenia: Key talking points as Rob Page’s side face crunch qualifier

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West Ham skipper Declan Rice does not know if he has played his last game for the club after the Europa Conference League victory over Fiorentina. The England midfielder has been linked with a move away from the Hammers this summer. And Rice may have signed off his West Ham career by becoming only the club’s third captain, along with Bobby Moore and Billy Bonds, to lift silverware in their 128-year history after the 2-1 victory in Prague. Rice told BT Sport: “It’s not a goodbye yet. Look at the moment there’s a lot of speculation about my future. “There is interest from other clubs, that’s out there, but ultimately I’ve still got two years left at West Ham (one year plus option). “There hasn’t been nothing yet (offers). Let’s wait and see, who knows. “I love every minute of it here, you can see the smile on my face. It’s not about that tonight, it’s about celebrating and that’s what I’m going to do now.”

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Centenarians tend to have lower levels of glucose, creatinine and uric acid from their sixties onwards, according to the largest study of its kind that may lead to a simple blood test to predict a person’s chance of reaching 100. The research, published on Monday in the journal GeroScience, is the biggest to date to measure and follow up the levels of different molecules in the blood of people born between 1893 and 1920. Scientists, including those from Karolinska Institutet, assessed the data on blood molecules from over 44,500 Swedes who underwent clinical testing between 1985 and 1996 and followed up till 2020. They focused specifically on people born between 1893 and 1920, who were between 64 and 99 years old when their blood samples were first tested, and followed them up as they grew closer to 100 years of age. About 1,200 individuals in the study, or about 2.7 per cent of the participants, reached 100. Researchers compared this subset’s data with those of their peers who were younger than them. The analysis found 12 blood-based molecules associated with metabolism, inflammation as well as liver and kidney function, that were also linked to ageing or mortality in previous studies. These molecules included total cholesterol and glucose as markers of metabolism, uric acid indicating inflammation levels, enzymes indicative of liver health and creatinine as a measure of kidney health. Researchers also looked at albumin and iron levels in the blood. Except for a liver enzyme and albumin, all other molecules were found linked to the likelihood of a person becoming a centenarian. Those with increased levels of total cholesterol and iron had a greater likelihood of becoming centenarians compared to those with lower levels. However, for molecules including glucose, creatinine, uric acid, and liver enzymes, lower levels were associated with higher chances of living past 100. “We found that, on the whole, those who made it to their hundredth birthday tended to have lower levels of glucose, creatinine and uric acid from their sixties onwards,” researchers wrote in The Conversation. “Very few of the centenarians had a glucose level above 6.5 earlier in life, or a creatinine level above 125,” they said. While the differences found in the study between groups were small in some cases, researchers said the findings still suggest a “potential link” between metabolism, nutrition and longevity. However, the study falls short of recommending lifestyle factors or genes responsible for these blood molecule levels. “While chance likely plays a role for reaching age 100, the differences in biomarker values more than one decade prior death suggest that genetic and/or lifestyle factors, reflected in these biomarker levels may also play a role for exceptional longevity,” scientists wrote in the study. “However, it is reasonable to think that factors such as nutrition and alcohol intake play a role. Keeping track of your kidney and liver values, as well as glucose and uric acid as you get older, is probably not a bad idea,” they said. Read More Good financial planning could increase life expectancy, study suggests Scientists find gene that grants long life – and successfully test it on another species Scientists extend mice lives by connecting their blood to young ones