
LA Reid is sued by former music executive over alleged sexual assaults
By Jonathan Stempel NEW YORK L.A. Reid, the music executive known for helping develop superstars like Mariah Carey,
2023-11-09 06:57

PGA Tour will appear before a Senate panel investigating its deal with Saudi backers of LIV
A Senate subcommittee is asking executives from the PGA Tour, Saudi golf interests and LIV Golf to testify as Congress investigates the shocking business deal that upended the sport
2023-06-22 07:35

Tottenham agree fee for Brennan Johnson with Nottingham Forest
Tottenham have agreed a fee in excess of £45million for Nottingham Forest forward Brennan Johnson. Spurs had made the Wales international their number one target following the sale of Harry Kane and looked to have got their man after agreeing a price with Forest, the PA news agency understands. Johnson will now undergo a medical, with there expected to be no complications in the deal going through before the 11pm deadline. The 22-year-old was a key player in Forest’s Premier League survival last season, scoring eight goals and notching three assists in a struggling side. Forest, who turned down two bids from Brentford for their homegrown player, will be able to satisfy Financial Fair Play requirements with the sale, due to Johnson’s development at the club. His pace and ability to stretch defences will appeal to Spurs, who have been keen on him for some time. Forest are trying to push through a permanent deal for Chelsea winger Callum Hudson-Odoi as a potential replacement, while also hoping to sign Argentina international Nicolas Dominguez. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live
2023-09-01 22:05

Liverpool's dream end to the summer transfer window
Liverpool's perfect end to the 2023 summer transfer window, with a look at current targets and potential sales.
2023-08-30 19:05

Terrell, Falcons defensive starters eager to make preseason debut against Bengals
Cornerback A
2023-08-16 02:34

New Zealand consumer confidence lifts in Oct but households remain wary- ANZ survey
SYDNEY Consumer confidence in New Zealand rose in October but more remained wary about purchasing major household items,
2023-10-27 05:25

Sky suspend F1 pundits after sexist comments live on air
Two Sky Italia commentators have been suspended after making sexist comments during the channel’s coverage of the Spanish Grand Prix on Sunday. Matto Bobbi and Davide Valsecchi made the remarks during live post-race coverage in Barcelona for Italian broadcaster Sky Sport. Referring to a woman in the background in the paddock, Bobbi, who was speaking from a separate studio, described her as an “upgrade package.” Valsecchi looked behind him and replied: “I know, but they told me I can’t test them. So I raise my hands.” Alongside Valsecchi was host Federica Masolin, who looked uncomfortable as the conversation progressed. She then interjected: “I ask for political asylum. Can’t we watch some interviews instead of listening to these two? Let’s hear from Carlos Sainz, please. I’m going to censor you two.” She then later read out a viewer’s comment on air, asking: “Will we see them [Bobbi and Valsecchi] safe and sound again at the next grand prix after these comments – that will be greatly appreciated by their wives?” Bobbi replied: “I think I’ll get a beating if I go home,” while Valsecchi said: “Well you know I’ve had eye surgery twice because I’ve been losing sight since I was a child, looking at those things.” Both have since apologised for their remarks but Sky Italia told The Guardian that Bobbi and Valsecchi have been “temporarily suspended” and will not work during the next race, the Canadian Grand Prix. Bobbi said: “I sincerely apologise to anyone who may have felt offended and wish to reiterate my total and profound respect for everyone and for women. “For 10 years, I have been commenting on F1 with friends from Sky, who have become like a family to me now and, in 10 years, I have never found myself in such an unpleasant situation. “I’ve always thought that you learn, understand and start again from your mistakes. What happened will lead me to try to improve further as a man and as a professional.” Valsecchi posted on Instagram: “I’m very sorry because, on Sunday, after the race, I exchanged some jokes that were in bad taste and used inappropriate and disrespectful words. “And I’m not like this. I would really like to apologise to those who felt offended, to women and to Sky.” Bobbi was a test driver for Minardi in the 2000s while Valsecchi won GP2 – now known as F2 – in 2012 but did not land a Formula 1 race seat. Read More F1 makes South African Grand Prix call for 2024 calendar F1 gives Canadian Grand Prix update after wildfires cause smoke to descend on Montreal F1 makes South African Grand Prix call for 2024 calendar F1 gives Canadian Grand Prix update after smoke descends on Montreal Lewis Hamilton: 18 months, 12 podiums and an elusive race victory
2023-06-09 22:05

Scientists may have just found a cure for alcoholism
Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.
2023-08-31 19:27

Valorant Slay Ride Buddy: How to Claim
The Valorant Slay Ride Buddy is still available for players to acquire by connecting their Riot Games and Amazon Prime accounts.
1970-01-01 08:00

Bang! ABC/ESPN's Breen enters rarified air in Game 5 of NBA Finals with 100th broadcast
Mike Breen is currently the dean of television announcers for the NBA Finals and he is about to enter rarified air space
2023-06-12 18:00

NASA hears signal from Voyager 2 spacecraft after mistakenly cutting contact
NASA says it has heard from its Voyager 2 spacecraft after a wrong command cut off communications
2023-08-01 21:25

'Today' host Al Roker pays precious tribute to wife Deborah Roberts on 28th anniversary: 'Through thick and thin'
'Today' host Al Roker posted photos on social media from his wedding in 1995 as he celebrated his 28th anniversary with Deborah Roberts
2023-09-17 12:35
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