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One of the scientists whose work pioneered the development of medications such as Ozempic and Wegovy has revealed why life may become “so miserably boring” after two years of using the drug. Ozempic is an FDA-approved medication used for the treatment of type 2 diabetes. It works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), which regulates blood sugar levels and slows down the rate at which food leaves the stomach, often creating the feeling of fullness. These semaglutide injections – sold under the brand names Ozempic and Wegovy – have soared in popularity as many people, including Hollywood celebrities, have used it for weight loss. What’s more, people have also found Ozempic has been effective in curing their addictive habits, like drinking, smoking, shopping, or nail biting. However, because of Ozempic’s increasing popularity, it has led to national shortages of the type 2 diabetes treatment – leaving those who actually need it without. In an interview with Wired, professor Jens Juul Holst – who received the Warren Alpert Foundation Prize in 2021 for his work developing treatments based on the GLP-1 hormone – spoke about the effects of Ozempic, and why he believes many people will stop taking the medication after just a few years. “What happens is that you lose your appetite and also the pleasure of eating, and so I think there’s a price to be paid when you do that,” Holst told Wired. “If you like food, then that pleasure is gone. The craving for food for some people is taken away when they take GLP-1 drugs.” He continued: “That may eventually be a problem, that once you’ve been on this for a year or two, life is so miserably boring that you can’t stand it any longer and you have to go back to your old life.” Holst added that medications like Ozempic and Wegovy have been on the market since 2005, though studies show that these people don’t stay on them for very long. “It’s just like every other drug, they don’t stay on it for many reasons,” he explained. “One of the reasons, as I said, is that once you have tried it and you realise you’ve lost interest in food, then that may be enough.” “We don’t know why people stop taking these drugs, but we know for a fact that they do stop. They do that all over the world.” A 2020 study found that 70 per cent of people who took GLP-1 drugs for type 2 diabetes stopped taking them within two years. However, this could pose a problem for many patients taking semaglutide injections. Research has found that people who stopped taking Ozempic or Wegovy for weight loss experienced weight rebound. A trial published in April 2022 saw participants gain back two thirds of the weight they had lost after 68 weeks of taking semaglutide. As for celebrities who use the once-weekly injection for weight loss, despite not having diabetes or clinical obesity, Hans instead called attention to the “many terrible problems” that those with diabetes have struggled with by not having drugs like Ozempic readily available. “Have you ever visited a diabetes hospital? It’s really deplorable,” he said. “People come in with amputated limbs and compromised cognitive functions and heart problems or they can barely move – they’re miserable and depressed. It’s really serious. There is so much you can improve with a drug that is not only a weight-loss drug but is also an anti-diabetic.” Amidst the popularity of semaglutide injections, the US Food and Drug Administration has issued warnings for consumers not to use off-brand versions of Ozempic or Wegovy, because they may not include the same GLP-1 hormone used in approved medications. Earlier this month, agency officials reported problems with patients using compounded versions of semaglutide – which combines traditional semaglutide with other ingredients. These drugs are not FDA-approved, and the agency does not verify the safety or effectiveness of compounded drugs. Consumers should only use drugs containing semaglutide with a prescription from a licensed health care provider and obtained from a state-licensed pharmacy or other facilities registered with the FDA, the agency said. Read More What is ‘Ozempic face’? Doctors warn about facial ageing side effect of diabetes medications How does Wegovy work? The ‘game changing’ weight loss drug beloved by Hollywood FDA warns against using off-brand versions of Ozempic, Wegovy for weight loss Pregnant Stassi Schroeder admits she wants to ‘try’ Ozempic after giving birth Doctors warn about ‘Ozempic face’ side effect of medications Amy Schumer says she stopped taking Ozempic because of side-effects

Something is different at Tottenham: check the table, they are top and playing like league leaders as well. Ange Postecoglou’s side returned there after confidently asserting their superiority over Fulham in this comfortable 2-0 win in north London. Tottenham extended their best start to a season since 1960 with a helping hand from the visitors, who were hapless, and Calvin Bassey, who was culpable for both goals and fortunate it wasn’t more. Spurs, in essence, scored the same goal twice, with Bassey giving away possession with a loose pass into midfield and Micky van de Ven sharply intercepting on the half-way line. Son dispatched the first on 36 minutes after dancing past Bassey and curling into the top corner; then Son set up James Maddison to double their lead shortly after half-time. The finish, again, was ruthless. Spurs could have been out of sight long before then had Richarlison and Dejan Kulusevski been as clinical, but a seventh victory out of nine so far in the Premier League never felt in doubt after Son continued his own excellent start to the campaign. Spurs enjoyed periods of control and flowed forward dangerously. There was, significantly, a sense that Tottenham’s players were enjoying this. Clearly, that is mirrored in the stands as well: if Postecoglou has arrived and convinced Tottenham they can be something new, the fans chosen to be fun and carefree. It is not surprising, therefore, that that spirit has been brought by those who did not play here under Antonio Conte or Nuno Espirito Santo or Jose Mourinho, and who embody the fresh start that Postecoglou has been able to make. The Australian’s four summer signings who started against Fulham, in Maddison, Van de Ven, goalkeeper Guglielmo Vicario and Destiny Udogie, were all outstanding again. If Postecoglou’s presence has lifted Spurs, they are the ones who carry his message onto the pitch. Maddison’s quality is obvious in every touch, as is the idea that he has taken responsibility to drag Tottenham out of the existential crisis they faced here last season. The centre-back Van de Ven has become an unlikely fan favourite, bringing an energy and enthusiasm into every defensive action. Tottenham’s two goals would not have been scored without him and it was an illustration of why the German has become so appealing to the fans here: he wants this, and he’s doing it for you. Add in the quality that was already here and this Tottenham side has the makings of something exciting: how good this team really is remains to be seen, but another remarkable aspect of the transformation under Postecoglou is how those who appeared beaten and washed out last season have been revived. Son is devastating again, Kulusevski threatening with every touch, his dribble returning to such a fine, gliding motion. Perhaps most extraordinarily of all, Cristian Romero has emerged as the calm head guiding the defence. Yet in the first half, it was Udogie who shined brightest in spells, the 20-year-old a fearless example of what Tottenham are now all about. In his hybrid role from full-back, the Italian is already becoming vital to this attacking, dangerous Spurs, often playing further forward then Maddison when Postecoglou’s side have possession. Udogie, with his ability to receive the ball with back to goal, absorb pressure, and then shrug it off like a discarded cloak, offered a threat that Fulham struggled to pin down – the visitors breathed a sigh of relief when he was removed as Tottenham went 2-0 up. Udogie went off to a standing ovation. Son turned and beckoned for more. Meanwhile, there is Vicario, who looks as if he won’t concede a goal ever again. Already with the best save percentage in the Premier League before Monday night, the Italian has stepped in to give Tottenham a secure and reassuring presence. The goalkeeper appears built to handle the nervy moments that invariably come with playing for Tottenham, a part that Hugo Lloris, for all his years here, never felt quite fit for. Because for all that Tottenham were dominant against Fulham and the only team who ever looked capable of winning, there have previously been times where such a script has gone wildly off course. On 12 minutes, Vicario was there with an excellent leap and strong left arm to deny Palhinha’s free header, in what was the visitors’ first attack. It was a moment that came after a spell of overwhelming Tottenham dominance, and therefore a natural point for them to concede. But Fulham barely threatened again until it was too late. Silva’s side were a mess at the back, the absence of Issa Diop at the back compounded by Bassey’s woefully inaccurate performance. Fulham teased Tottenham with their reckless play into midfield: it may have worked in the past, against a passive Spurs, but Van de Ven and the excellent Pape Matar Sarr snapped into challenges and from there Fulham leaked chances like a sieve. And so, Postecoglou’s different Spurs left the Premier League table looking as it did at the start of the weekend: Tottenham are back at the top and looking down. Read More Tottenham Hotspur vs Fulham LIVE: Latest Premier League updates Ange Postecoglou hopes Tottenham can offer fans ‘escape’ from Israel-Hamas conflict Tottenham reveal Rodrigo Bentancur injury update as key midfielder nears return Can Tottenham’s best-ever Premier League start really go the distance? 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The Saudi Pro League is "determined to be a success" and will keep splashing the cash to attract some of the biggest names in football, according...