John Toshack signed a five-year contract to become the new manager of Wales on this day in 2004. Former Liverpool striker Toshack, then 55, took the helm for the second time 10 years after lasting just a single game in his first spell. He had been appointed on a part-time basis in 1994, combining his duties with his role as manager at Real Sociedad, but resigned to concentrate on his club responsibilities following a 3-1 defeat by Norway. The Football Association of Wales turned to a man who had won 40 caps for his country for a second time a decade later having drawn up a three-man shortlist which also included Dean Saunders and Philippe Troussier after Gerard Houllier had declined an interview. Toshack, who had been outspokenly critical of predecessor Mark Hughes in his role as a pundit, arrived with the Welsh having missed out on qualification for the Euro 2004 finals after a play-off defeat by Russia and with their World Cup qualification hopes hanging in the balance following a return of just two points from their opening four games of the campaign. He said at the time: “While it’s mathematically possible that we can qualify, we realise that this particular campaign is by no means easy. “But by the time the European Championship qualifiers come round in September 2006, we’ll have a pretty good idea what sort of side I’ve got. Hopefully by results and hard work, we’ll be able to achieve our objectives.” Toshack, who launched his coaching career as player-manager at Swansea and guided the club from the fourth to the first division before heading for Sporting Lisbon, Sociedad, Real Madrid, Deportivo La Coruna and Besiktas, went to work with his eyes wide open. Draws with Azerbaijan and Northern Ireland and defeats by England and Poland meant he inherited a difficult situation, and it was not improved by back-to-back defeats by Austria. Wales ultimately finished fifth in the group despite wins over Azerbaijan and Northern Ireland in their final two games. Toshack remained at the helm for almost six years, blooding a new generation of players as the likes of Robbie Savage, Gary Speed, Ryan Giggs, Jason Koumas and Simon Davies made way for youngsters Gareth Bale, Joe Ledley, Aaron Ramsey, Chris Gunter and Jack Collison. However, appearances at the finals of major tournaments continued to elude them and, after a 1-0 defeat by Montenegro in their opening Euro 2012 qualifier in Podgorica in September 2010, he left his post by mutual consent. Toshack departed having overseen 21 wins in 53 games during which he capped 43 new senior internationals and was succeeded three months later by Gary Speed. Read More Gareth Southgate: England have won over the world – now for our own fans It is hard to overtake Manchester City under Pep Guardiola – Mauricio Pochettino Pep Guardiola: Only small clubs worry about selling players to their rivals Rob Page: Harry Wilson has been one of Wales’ main men since Gareth Bale retired Kieran Trippier confronted by angry Newcastle fans after defeat at Bournemouth She’s a tough cookie – Jodie Burrage backed to bounce back from nightmare debut

The man charged with shooting three college students of Palestinian descent in Vermont was accused in 2019 of harassing an ex-girlfriend in New York state

DUBAI, United Arab of Emirates--(BUSINESS WIRE)--Oct 31, 2023--

Carlo Ancelotti will stand trial for tax fraud after the Real Madrid coach allegedly failed to declare image rights earnings in 2014...

Despite David Stearns suggesting that a new Pete Alonso contract could be on the way, the Chicago Cubs remain interested in the first baseman.

No. 11 Missouri will try to keep improving its bowl standing in its home finale against Florida on Saturday night

After nearly 10 years of playing the same lottery number combination, a $50,000 payday has finally arrived for a man in Maryland, lottery officials said.

Scientists have grown human kidneys in pigs, for the very first time. Researchers at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences and Wuyi University created human-pig chimeric embryos containing a combination of human and pig cells. When they transferred into 13 surrogate pig mothers, they developed kidneys that contained mostly human cells at a rate of 50 to 60 per cent, giving hope for potential transplants in the future. “Rat organs have been produced in mice, and mouse organs have been produced in rats, but previous attempts to grow human organs in pigs have not succeeded,” said the senior author Liangxue Lai. “Our approach improves the integration of human cells into recipient tissues and allows us to grow human organs in pigs.” The kidneys were not entirely human as they included vasculature and nerves made mostly from pig cells, meaning they could not be used for transplantation in their current form, but it is still a pretty impressive step. And apart from the kidneys, the embryos were dominated by pig cells, with very few human cells in the brain or central nervous system. Making brains using human and pig cells is very controversial for ethical reasons, so there are tight regulations for this kind of research. Meanwhile, pig cells tend to outcompete human cells during development, so previous experiments have created embryos that are almost entirely pig. The latest work, published in Cell Stem Cell, overcame this by genetically engineering a single-cell pig embryo so that it lacked two genes needed for kidney development. This created a gap within the embryo that could be filled by human cells. “We found that if you create a niche in the pig embryo, then the human cells naturally go into these spaces,” said Prof Zhen Dai of Guangzhou Institutes of Biomedicine and Health, another senior author. The scientists said that being able to incubate a fully human kidney inside a pig would be likely to take many years. “We would probably need to engineer the pigs in a much more complex way and that also brings some additional challenges,” said Miguel Esteban, also of the Guangzhou institute and a senior author. A central challenge would be to allow human nerves and vasculature to develop within the target organ without nerve cells developing in the central nervous system that could lead to a humanised brain. “Even theoretically it’s not clear how you’d do that,” said Ilic. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Pakistan opened their World Cup campaign with a comfortable 81-run win against the Netherlands on Friday, overcoming an impressive performance from...

Ipswich midfielder Massimo Luongo believes the Sky Bet Championship new boys can take the division by storm thanks to a manager “setting the bar” for modern coaches. The Tractor Boys are back in the second tier for the first time in five seasons after they scored 101 goals to secure promotion from League One and travel to Sunderland this weekend. Former Manchester United coach Kieran McKenna is the man behind Ipswich’s revival and Luongo, currently nursing a minor groin strain, admitted the draw of working with the 37-year-old was the decisive factor in a return to Portman Road after a loan spell in 2012. Under the stewardship of McKenna, in his first senior managerial role, Ipswich entertained League One last season with a brand of attacking and possession-based football not usually associated with success in England’s lower-leagues. While Luongo is under no illusions about the Championship being a big step up, he is fully swept up in the excitement that has been present at the Suffolk outfit since McKenna’s arrival in the winter of 2021. He told the PA news agency: “We have a good blend of boys ready to make the jump up and boys prepared to do the normal business. It is definitely one with a lot of anticipation and we’re all excited. I am definitely excited. “It is definitely a step up, physically it is a step up. The difficult thing is how you compare because we dominated so many games in League One so physically they are not as demanding as games in the Championship. “Everyone has the typical Champ game references when you watch Championship football and it comes around a lot. “But I think with Ipswich, after Burnley last year, we will try to be the exception where you are not saying that. “We want to play out from the back, play good football, be entertaining, so it will be a challenge but the players we have got are all looking forward to it.” Australia international Luongo is delighted to be established at a club for the start of this season after enduring a difficult time last summer. Luongo had to wait until September to find a new club before he failed to make an appearance during his short stint at Middlesbrough and had largely “written off the season” when Ipswich registered their interest before January. The lure of being managed by ex-Tottenham Under-18s boss McKenna, after crossing paths at Spurs, helped the 30-year-old get over a largely disappointing 2022 to become a key figure for Ipswich and he netted in the 6-0 victory over Exeter that clinched promotion in April. “With Ipswich there was some history there, I enjoyed it last time and probably the manager was the biggest pull. I came across him a little bit at Tottenham and over my career he kept track of me. I had also heard a lot of good things,” Luongo said. “What is striking for me is his detail in how he wants to play. On the pitch, the detail is at a really, really high level, like the information we receive and the feedback we receive from the coaches. We want to play out from the back, play good football, be entertaining, so it will be a challenge but the players we have got are all looking forward to it. Ipswich midfielder Massimo Luongo “And the way he conducts himself. He is in early, watches every second of training and loves football, I feel like he watches every single game because he pulls out games like that. “His knowledge of modern football is really good and he is obsessed with football to be honest. That bleeds into the team and we can all see it. “You can tell he loves football, is obsessed with it and wants to improve as a coach and manager so you can imagine what he wants for us and demands from us. “I enjoy coming in every day, for sure. The coaching staff and him have definitely created an atmosphere where we are firstly humble. “We don’t leave any stone unturned, it doesn’t matter who we play against. Then when we win, stay humble and when we lose, don’t get too low. They have done a really good job of that. “The manager has mixed with good people at Man United, his background with where else he has learnt and stayed, so I think the football we are playing is probably setting the bar for modern day managers of what is required. “It is interesting because I have had a little spell of (Michael) Carrick and I can see the same with Kieran as well, so it is a good place to be.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Football rumours: Chelsea’s Romelu Lukaku player swap bid hits snag On This Day in 2008 – Kevin Pietersen appointed England Test and one-day captain World Cup winning coach Jill Ellis blown away by ‘unpredictable’ tournament

Positivity has been the watchword for Ben Stokes since taking over as England cricket captain a year ago and he oozed it on the eve of a highly anticipated Ashes series against Australia

Donald Trump is continuing to relish the news that cocaine was discovered at the White House, moving on from suggesting that it belonged to his successor Joe Biden and the latter’s son Hunter Biden, who has spoken out frankly about his past struggles with addiction, to claiming that the Biden administration is withholding the CCTV footage that might reveal the truth. “Where are the White House SECURITY TAPES, like the ones I openly and happily gave to Deranged Jack Smith, which will quickly show where the Cocaine in the White House came from???” he asked on his Truth Social platform on Wednesday evening. “They already know the answer, but probably don’t like it!” Meanwhile, the former president’s own son, Donald Trump Jr, has been branded “a big baby” by Australian home minister Clare O’Neil after he cancelled a planned speaking tour of the country, citing visa issues. “Geez, Donald Trump Jr is a bit of sore loser,” Ms O’Neill wrote in a series of posts on Twitter that were later deleted. “Donald Trump Jr has been given a visa to come to Australia. He didn’t get cancelled. He’s just a big baby, who isn’t very popular.” Read More Trump marks Independence Day by sharing vulgar attack on Biden and ominous 2024 warning Trump-appointed judge blocks Biden agencies from communicating with social media platforms Ex-New York congressman pardoned by Trump is planning to run again in Florida Truth Social’s merger partner reaches $18m settlement with SEC