The United States and the Philippines have signed a nuclear cooperation pact under which U.S. investment and technologies are to help the Southeast Asian nation transition to cleaner energy and bolster its power supply

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Some of Donald Trump’s top rivals for the Republican presidential nomination plan to speak at a gathering of influential evangelical Christians in Iowa on Saturday night

The top election official in Wisconsin appears poised to remain in her post for now -- after state election commissioners deadlocked Tuesday on her reappointment.

After a summer where the Miami Heat were hoping to land Damian Lillard, the reigning Eastern Conference champions reported for training camp on Monday with a familiar refrain in mind

A Russian missile struck a school in the town of Nikopol in the central Ukrainian region of Dnipropetrovsk on Wednesday, killing at least four people, Ukrainian officials said. “As a result of the Russian strike, four people died: a 72-year-old man and three women aged 69, 67 and 60,” Interior Minister Ihor Klymenko said on the Telegram messaging app. Two people who were injured were receiving medical assistance, he added. Klymenko said earlier that the victims were employees at the school. Serhiy Lysak, the regional governor, said 50 private homes and two infrastructure facilities had been damaged. It comes as Vladimir Putin is set to visit Kyrgyzstan on Thursday, the presidential office of the Central Asian country said, in what would be the Russian leader's first known trip abroad since the International Criminal Court issued a warrant for his arrest. Meanwhile, Russia has failed in its bid to return to the United Nations’ top human rights body on Tuesday, in a sign Moscow will continue to be isolated on the international stage. Read More Ukraine President Zelenskyy at NATO defense ministers meeting seeking more support to fight Russia Russia loses vote to rejoin UN’s top human rights body despite Putin’s charm offensive with stolen grain Ukraine’s forces repel Russian attacks near Avdiivka as Putin’s troops launch new offensive

An array of technology leaders and advocates are headed to Capitol Hill on Tuesday afternoon to propose how

Here's a breakdown of how to claim the Win Together Loading Screen for Apex Legends.

Almost 300 babies are born in the UK with sickle cells every year, according to the Sickle Cell Society, and the effects of sickle cell disease are believed to impact thousands. Yet, many people may not even know what sickle cells are or what living with the condition means. What is sickle cell disease? In most people, red blood cells are disc shaped and move easily through the blood vessels. But if you have sickle cell disease, your red blood cells are shaped like a sickle (similar to a crescent moon). This stops them moving with ease through the body and blood flow becomes restricted. Sickle cell disease isn’t actually one specific disease – it refers to a group of conditions affecting people with sickle cells, which range in severity.The conditions are inherited and predominantly affect people from African and Caribbean family backgrounds. What are the symptoms of sickle cell disease? Symptoms begin early in childhood and can sometimes be debilitating. How each individual is affected may vary, but the main symptoms are anaemia, an increased risk of infections, and pain. This includes extremely painful episodes called ‘sickle cell crisis’, which happens when blood flow to certain parts of the body become blocked. According to the NHS, these episodes can last for days and require hospitalisation. Other issues are associated with the condition too, including problems with the lungs, delayed growth in childhood, higher risk of stroke, leg ulcers and sight/vision problems.How is it diagnosed? Sickle cell disease is usually picked up during pregnancy or shortly after birth, although a blood test can be given at any time to see if someone has the condition or carries sickle cell genes. In parts of the country, pregnant people will be offered a test to see what the chances are of their child having sickle cells. Infants can be checked for the cells through a heel prick test.How do you treat it? Treating sickle cell disease is usually a lifelong process to help people with pain and to stay as healthy as possible. Treatment takes place in specific sickle cell centres and those living with it are encouraged to take care of their health, no matter the severity of their symptoms. Managing pain is a huge part of treating sickle cell disease. Staying hydrated can be helpful, as well as avoiding sudden temperature changes, like getting into a cold shower or diving into water. According to the NHS, Hydroxycarbamide (hydroxyurea) may be recommended, which is taken as a pill once a day. This can lower the quantity of other blood cells and requires careful monitoring, however. Some people may also be able to have a medicine called crizanlizumab, either on its own or alongside hydroxycarbamide, usually injected into a vein every four weeks. To prevent infections, many people with sickle cell disease will take daily antibiotics. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live TikTok has gone wild for adult gymnastics – here’s what you should know Man explains why he swapped veganism for raw meat diet: ‘I feel great’ Rugby star Ugo Monye: Boarding school shaped my career and my personality

Joe Lycett is back at trolling the Conservative party again, this time Suella Braverman, after the Court of Appeal ruled that the government's Rwanda asylum plan is "unlawful". Lord Burnett, the outgoing Lord Chief Justice, said: "The High Court's decision that Rwanda is a safe third country is reversed. Unless and until the deficiencies in its asylum processes are corrected, removal of asylum seekers to Rwanda will be unlawful." A major setback in prime minister Rishi Sunak's 'stop the boats' policy. Sign up to our free Indy100 weekly newsletter In light of the announcement comedian Joe Lycett tweeted: "ignore the haters babe (by haters I mean the royal court of justice)" Lycett has been known to troll many Conservative MPs, after former prime minister Boris Johnson was found guilty for lying to parliament earlier this month, Lycett tweeted "@Boris Johnson still my king." Similarly, when Liz Truss announced her resignation in October last year, the comedian tweeted: "@trussliz omg just heard there's a leadership election next week????? u shud run bab youd be perfect!!!" Lycett gained a lot of attention last year for his appearance on Sunday with Laura Kuenssberg after sarcastically claiming to be "very right-wing". "The haters will say that we've had 12 years of the Tories and that we're sort of at the dregs of what they've got available," the comedian said last year. "I wouldn't say that because I'm incredibly right-wing, but some people might say that." Many fans once again loved Lycett's comedic input to the current situation, with his tweet having thousands of likes. "Tweet of the day," commented one user. Others took inspiration from Lycett's sarcastic remarks and left some of their own: A government source said it was likely to challenge the ruling at Britain's Supreme Court. Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Maine Gov. Janet Mills has signed into law a supplemental budget that includes establishment of a paid family and medical leave program

Students at a Florida university were warned to shelter-in-place after shots were fired at the nearby Gulf Coast Town Center shopping mall on Wednesday morning. Florida Gulf Coast University sent an alert to students after shots were reported at a construction site at the mall 15 miles (24kms) south of downtown Fort Myers at around 11.15am. Lee County Sheriff’s Office deputies responded to the shooting, and later confirmed that no shoppers had been hurt. They are searching for the occupants of two cars who fled the scene. The Florida Gulf Coast University police department posted an update at around 1.30pm to say there was no active threat and there had been no danger to students on its main campus. The university said on social media that an alert about an active shooter on campus was sent out in error. Lee County Sheriff Carmine Marceno said in a social media post that the shooting appeared to have been an isolated altercation between two vehicles that had since fled. He said no businesses had been affected, but to expect an increased law enforcement presence in the area. Florida Gulf Coast University had an enrollment of 16,000 students in 2022. Read More Rising political threats take US into uncharted territory as 2024 election looms Attacks at US medical centers show why health care is one of the nation's most violent fields Maui police chief pleads for patience, recalls pain of victim IDs after deadly Vegas mass shooting