Pope Francis warned Wednesday the world "is collapsing" due to global warming, urging participants of the upcoming COP28 climate talks to agree to binding policies...

Generations are often characterized by their relationship with technology. Baby boomers were the first to

Unborn babies are in a perpetual nutritional tug-of-war with their mothers due to a “greedy” gene inherited from their fathers, a new study suggests. Scientists from the University of Cambridge have found that foetuses use the gene to “remote-control” their mother into feeding them extra food and control her metabolism. While the mother’s body wants the baby to survive, it needs to keep enough glucose and fats circulating in her system for her own health in order to be able to deliver the child, breastfeed, and reproduce again. Amanda Sferruzzi-Perri, professor in Foetal and Placental Physiology, a Fellow of St John’s College and co-senior author of the paper, said: “It’s the first direct evidence that a gene inherited from the father is signalling to the mother to divert nutrients to the foetus.” Dr Miguel Constancia, MRC investigator based at the Wellcome-MRC Institute of Metabolic Science and co-senior author of the paper, said: “The baby’s remote control system is operated by genes that can be switched on or off depending on whether they are a ‘dad’s’ or ‘mum’s’ gene’, the so-called imprinted genes. “Genes controlled by the father are ‘greedy’ and ‘selfish’ and will tend to manipulate maternal resources for the benefit of the foetuses, so to grow them big and fittest. “Although pregnancy is largely cooperative, there is a big arena for potential conflict between the mother and the baby, with imprinted genes and the placenta thought to play key roles.” The new study looked at how the placenta communicates with the mother through the release of hormones so she can accommodate her baby’s growth. In pregnant mice, scientists selectively altered the signalling cells in the placenta that tell mothers to allocate nutrients to her developing foetuses. The baby’s genes controlled by the father tend to promote foetal growth and those controlled by the mother tend to limit foetal growth, experts say. Professor Sferruzzi-Perri explained: “Those genes from the mother that limit foetal growth are thought to be a mother’s way of ensuring her survival, so she doesn’t have a baby that takes all the nutrients and is too big and challenging to birth. “The mother also has a chance of having subsequent pregnancies potentially with different males in the future to pass on her genes more widely.” In the study researchers deleted the expression of an important gene called Igf2, which provides instructions for making a protein called “Insulin Like Growth Factor Two”. Similar to the hormone insulin, which is responsible for making glucose and controlling its levels in our circulation, the gene promotes foetal growth and plays a key part in the development of tissues including the placenta, liver, and brain. Dr Jorge Lopez-Tello, a lead author of the study based at Cambridge’s department of physiology, development and neuroscience, said: “If the function of Igf2 from the father is switched off in signalling cells, the mother doesn’t make enough amounts of glucose and lipids – fats – available in her circulation. “These nutrients, therefore, reach the foetus in insufficient amounts and the foetus doesn’t grow properly.” The scientists found that deleting the gene also affects production of other hormones that modulate the way the mother’s pancreas produces insulin, and how her liver and other metabolic organs respond. Babies with Igf2 gene defects can be overgrown or growth-stunted. And the researchers say that until now, it was not known that part of the gene’s role is to regulate signalling to the mother to allocate nutrients to the unborn child. The mice studied were smaller at birth and their offspring showed early signs of diabetes and obesity in later life. Professor Sferruzzi-Perri said: “Our research highlights how important the controlled allocation of nutrients to the foetus is for the lifelong health of the offspring, and the direct role the placenta plays. “The placenta is an amazing organ. At the end of pregnancy, the placenta is delivered by the mother, but the memories of how the placenta was functioning leaves a lasting legacy on the way those foetal organs have developed and then how they’re going to function through life.” The findings are published in the Cell Metabolism journal. Reporting by PA Read More It took until my thirties to realise I might not be white Carrie Johnson announces birth of third child with Boris Johnson: ‘Guess which name my husband chose’ How many children does Boris Johnson have? The meaning behind the name of Carrie and Boris Johnson’s third child Emilia Clarke’s brain haemorrhage ‘profoundly changed our lives’, says star’s mother How many children does Boris Johnson have?

Saracens director of rugby Mark McCall has criticised the "shameful" treatment of Owen Farrell after the England fly-half opted to take a break from international...

KYIV Ukraine's military spy chief said on Thursday that the threat of a Russian attack on the vast

League of Legends Patch 13.3 has released and there is an evolving meta in the jungle. Maokai, Wukong, Vi, Udyr, and Kindred are some champions that will help achieve victory.

Rakim Paulin and Jeremy Taylor were arrested and charged after allegedly driving in the opposite direction on the road, leading to a confrontation

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GRAND CAYMAN, Cayman Islands--(BUSINESS WIRE)--May 9, 2023--

Deja Taylor has reportedly admitted that her gun was stored in a way that the boy could access it.

New findings have revealed that time ran five times slower in the early universe, after scientists published new research into quasars. A quasar is a luminous active galactic nucleus and studying them has allowed scientists to measure time. The variation in brightness of quasars from the early universe has been measured to determine time dilation back to a billion years after the Big Bang. Experts have found that there was an era in which clocks moved five times slower than they do in the present day. The findings come as a relief to many cosmologists who have been perplexed by previous results that have come from studying quasars. The discovery that the universe is expanding led to the theorisation of “time dilation” – the idea that time moved slower the smaller the universe was. Sign up to our free Indy100 weekly newsletter Professor Geraint Lewis of the University of Sydney, the lead author of a new study, said in a statement: “Looking back to a time when the universe was just over a billion years old, we see time appearing to flow five times slower.” He continued, explaining: “If you were there, in this infant universe, one second would seem like one second – but from our position, more than 12 billion years into the future, that early time appears to drag.” To measure the extent of time dilation, scientists turned to quasars, as they are able to measure their change in brightness over a period they can estimate. The most distant quasar that is visible is 13 billion back in time and can still be seen despite its far distance. Their brightness varies due to turbulence and lumpiness in their accretion disks. Lewis explained the phenomenon as being “a bit like the stock market”. He said: “Over the last couple of decades, we’ve seen there is a statistical pattern to the variation, with timescales related to how bright a quasar is and the wavelength of its light.” Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Asher Hong overcame an uncharacteristic fall on the floor exercise to take the lead after the opening round of the U.S. men’s gymnastics championships