As if a shrinking audience of traditional viewers and advertisers pulling back in a wobbly economy weren’t enough,

Police have advised drivers to take extra care when driving as high winds and rain can cause difficulties

Man Utd have confirmed the departures of six players as free agents after their contracts expired.

As the season nears its end, the fight for the division in the AL East has been grabbing headlines to see who will come away with the glory: the Baltimore Orioles or the Tampa Bay Rays.

Researchers have revealed how muscle cells deteriorate with age, affecting their ability to regenerate and recover after an injury. The findings could help to shed light on why it takes people longer to recover from muscle damage as they age. A team at Nottingham Trent University analysed the genes inside muscle cells, and found the ‘development pathways’ – the different ways in which genes work together to regenerate muscle – become weakened in older cells. We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get Dr Livia Santos, Nottingham Trent University Lead researcher Dr Livia Santos, an expert in musculoskeletal biology in Nottingham Trent University’s School of Science and Technology, said: “This goes some way towards explaining why muscle injuries may take longer to recover as we get older.” She added: “We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get. “What we’ve observed, in terms of what happens inside the cells, helps us to better understand why we don’t heal as well or as quickly in older age. “The pathways that control cell processes and development work differently in older cells and are downregulated, meaning regeneration is impacted the older we get. “If we can understand these pathways, however, we could potentially identify new therapies and interventions to mitigate the problem.” The researchers developed a new approach to examine muscle cells in the laboratory to enable them to observe the different mechanisms that drive muscle ageing. They studied muscle cells from donors, chemically injuring cells after they had been donated and isolated, then assessing how they heal and regenerate back to their pre-injury baseline levels. When they looked at cells from a 20-year-old and a 68-year-old donor, researchers found distinct differences in the development pathways of the younger and older cells. While younger muscle cells fully recovered from the injury, the team found that in older cells the genes expressed less of what they needed to, leaving the cells no longer able to perform in the way they should. According to the researchers, this contributes to reduced regeneration capacity leading to thinner, less robust ‘myotubes’ – a type of cell that can fully develop into a muscle fibre. Muscle regeneration is a complex and finely balanced biological process and is known to deteriorate with ageing, leading to the decline of musculoskeletal health and in some cases metabolic and genetic diseases. Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing Researcher Janelle Tarum Janelle Tarum, another researcher on the study, said: “We’ve been able to develop a new approach to assess muscle regeneration which involves a state-of-the-art technique called RNA-sequencing. “There’s a very clear reduced regeneration capacity and weakened recovery of aged cells and we have been able to further understand the factors underlying this impairment. “Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing.” The study, which also involved Manchester Metropolitan University and Liverpool John Moores University, is published in the Journal of Tissue Engineering and Regenerative Medicine.

US restrictions on advanced computer chips are forcing China's tech giants to rethink their ambitious...

SCOTTSDALE, Ariz.--(BUSINESS WIRE)--May 23, 2023--

About 1.7 million Afghan refugees have been told to leave Pakistan and now face an uncertain future.

Mitch Garver blasted a third-inning grand slam as the Texas Rangers moved to within one win of ending the Baltimore...

Hollywood stars have often expressed their well-thought-out plans for their own funerals

Ukrainian troops have conducted a “series of successful operations” against Putin’s troops following a breakthrough on the eastern bank of the River Dnipro. In a statement, the Ukrainian Marines said they had established several bridgeheads across the river in the Russian-occupied part of Kherson region and were continuing to carry out operations. It comes as Russia intensified its strikes on Ukrainian ports overnight, including Odessa. The Ukrainian air force said it downed nine out of 10 Iranian-made Shahed drones over Mykolayiv and Odessa. Meanwhile, Ukraine forced Russia’s naval fleet to pull back in the eastern part of the Black Sea, president Volodymyr Zelensky has claimed. “For the first time in the world, it was in the Black Sea that a fleet of naval drones began to operate – a Ukrainian fleet,” Mr Zelensky wrote on Telegram. “I would also like to note that now – as one of the main results of our actions – Russia is unable to use the Black Sea as a springboard to destabilise other regions of the world.” Read More David Cameron meets Zelensky in Ukraine in first visit as foreign secretary – and praises Boris Johnson In Russia, more Kremlin critics are being imprisoned as intolerance of dissent grows Russian court convicts a woman for protesting the war in Ukraine in latest crackdown on free speech Bombs, betrayal and burying loved ones: Plight of one Ukraine village illustrates toll of Russia’s invasion

Liverpool manager Jurgen Klopp has called for their match against Tottenham to be replayed due to the glaring VAR error which cost them the opening goal. The fall-out from the VAR failure in Saturday’s defeat – in which officials wrongly disallowed Luis Diaz’s goal due to a misunderstanding of the on-field decision – is still being felt. The Premier Game Match Officials Ltd released the audio conversation between officials and the VAR after a request from Liverpool, but Klopp said that had made little difference to their thinking. “The audio didn’t change it at all. It is an obvious mistake,” he said. “I think there should be solutions for that. I think the outcome should be a replay. “The argument against that would be it opens the gates. It is unprecedented, it has not happened before. “I’m used to wrong and difficult decisions, but something like this never happened and so that is why I think a replay is the right thing to do.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live