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Mauricio Pochettino said his Chelsea players need to grow up as a team after they were beaten 1-0 at Stamford Bridge by Aston Villa to fall to their third loss of the season. The game turned with the sending off of Chelsea’s Malo Gusto after 58 minutes when the score was still 0-0. His challenge on Lucas Digne was late and caught the Villa defender on the ankle, and after a pitchside VAR review referee Jarred Gillett upgraded the initial yellow card to a red for dangerous play. Pochettino brought on Ben Chilwell and moved Axel Disasi to right-back, but the dismissal did not much alter Chelsea’s attacking intent as they continued to seek out a winner. It was a decision that would come to haunt them, as with the home side committed inside Villa’s half Moussa Diaby broke with the ball and fed Ollie Watkins, who after seeing his first shot blocked by Levi Colwill scored with his second, angling the ball beyond Robert Sanchez and in off the far post. It was the second time in two seasons that Watkins has netted in a Villa victory at Stamford Bridge, as Unai Emery’s side took full advantage of Chelsea’s ongoing inability to turn promising situations in the final third into goals, before pouncing when their own moment came. Striker Nicolas Jackson, who has scored just once since his £31million summer move from Villarreal, again cut a frustrated figure as he picked up his fifth booking of the season for attempting to block a Villa free-kick, incurring him a one-game ban. Pochettino refused to criticise the officials and said it is the players that must take the rap for the team’s poor start to the season. “It’s our responsibility and the players’ responsibility,” said Pochettino. “We can’t blame the VAR or the referee. The situation, we need to act different, in a different way. I’m not going to blame or say anything against Malo Gusto. Situations happen in football and they affect the game and the team in a negative way. “We need to grow up like a team, not only in an individual way. A player like Nico (Jackson) that is so young, feeling the Premier League and he’s learning, he needs time. In this type of game, we’re competing and we want to win. But players, when they are young, need to learn with experience. “That’s why we feel disappointed because we are playing too many situations like this. Another small detail and in the end we are losing the game. We are in a situation we need to change as soon as possible.” Chelsea largely dominated up until the red card with Raheem Sterling and Mykhailo Mudryk particularly lively attacking down either flank. But the team were dogged by a familiar failure to turn pressure and possession into gilt-edged chances as their scoreless run in the league extended to three games. “It was a little bit unlucky,” said Pochettino. “How many chances did we have like Aston Villa? They shoot, we block, then they shoot and it touches the post and goes in. For us, how many one v one against (Emiliano) Martinez? We were a little bit unlucky but that happens. “We need to accept the reality. But it was unlucky because how many chances did they create? Not many. With 10 men we were forcing them to go back. We need to grow up like a team, not only in an individual way. In this type of game, we’re competing and we want to win. But players, when they are young, need to learn with experience. Mauricio Pochettino “That is unlucky. We need to be aware about what is going on but in some way we need to be calm because the team is creating, the team is alive, the team is fighting every single action. “We cannot say anything about the players, we cannot say that they gave up after 70 minutes. They were fighting until the end with one player less.” Villa boss Emery reflected on a performance that he said was proof of his side’s powers of recovery after their 3-2 loss to Legia Warsaw in the Europa Conference League on Thursday. “Overall I think we are progressing,” he said. “We changed some players, we had some difficult injuries. The most important thing, we tried to create our style and ideas as quick as possible with the players we added this season. “The first way to get it I think is to be consistency defensively, be competitive like we were today. “We’ve been strong at home, playing really good and winning a lot of matches. But away we have to try to get the same performances and the same structure. “Today, to win here at Chelsea, 90 minutes everything that happened today was something normal. To win here is not easy. If the match had gone different we could have lost as well. I’m very happy. We felt strong defensively, better than the last match we played away.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Sam Hain reveals sleepless night before impressive England debut Jurgen Klopp hails ‘massive steps’ made by Darwin Nunez after win over West Ham I don’t understand handball rule – Spurs’ Ange Postecoglou bemused by penalty

LOS ANGELES--(BUSINESS WIRE)--Oct 13, 2023--

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Researchers have revealed how muscle cells deteriorate with age, affecting their ability to regenerate and recover after an injury. The findings could help to shed light on why it takes people longer to recover from muscle damage as they age. A team at Nottingham Trent University analysed the genes inside muscle cells, and found the ‘development pathways’ – the different ways in which genes work together to regenerate muscle – become weakened in older cells. We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get Dr Livia Santos, Nottingham Trent University Lead researcher Dr Livia Santos, an expert in musculoskeletal biology in Nottingham Trent University’s School of Science and Technology, said: “This goes some way towards explaining why muscle injuries may take longer to recover as we get older.” She added: “We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get. “What we’ve observed, in terms of what happens inside the cells, helps us to better understand why we don’t heal as well or as quickly in older age. “The pathways that control cell processes and development work differently in older cells and are downregulated, meaning regeneration is impacted the older we get. “If we can understand these pathways, however, we could potentially identify new therapies and interventions to mitigate the problem.” The researchers developed a new approach to examine muscle cells in the laboratory to enable them to observe the different mechanisms that drive muscle ageing. They studied muscle cells from donors, chemically injuring cells after they had been donated and isolated, then assessing how they heal and regenerate back to their pre-injury baseline levels. When they looked at cells from a 20-year-old and a 68-year-old donor, researchers found distinct differences in the development pathways of the younger and older cells. While younger muscle cells fully recovered from the injury, the team found that in older cells the genes expressed less of what they needed to, leaving the cells no longer able to perform in the way they should. According to the researchers, this contributes to reduced regeneration capacity leading to thinner, less robust ‘myotubes’ – a type of cell that can fully develop into a muscle fibre. Muscle regeneration is a complex and finely balanced biological process and is known to deteriorate with ageing, leading to the decline of musculoskeletal health and in some cases metabolic and genetic diseases. Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing Researcher Janelle Tarum Janelle Tarum, another researcher on the study, said: “We’ve been able to develop a new approach to assess muscle regeneration which involves a state-of-the-art technique called RNA-sequencing. “There’s a very clear reduced regeneration capacity and weakened recovery of aged cells and we have been able to further understand the factors underlying this impairment. “Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing.” The study, which also involved Manchester Metropolitan University and Liverpool John Moores University, is published in the Journal of Tissue Engineering and Regenerative Medicine.

Carlos Alcaraz has replaced Novak Djokovic at No. 1 in the ATP rankings