Scientists in Israel have created a model of a human embryo from stem cells, without using sperm, eggs or a womb. A team at Israel's Weizmann Institute of Science made the model, which resembles an embryo at day 14, when it acquires internal structures but before it lays down the foundations for body organs, and the work was published in the journal Nature. But the scientists involved said it would take a long time yet to create an embryo from scratch. Team leader Jacob Hanna said the team took stem cells derived from adult human skin cells, as well as others cultured in the lab, then reverted the cells to an early state.They then manipulated them to make a model of an embryo, rather than an actual or synthetic one. "The question is, when does an embryo model become considered an embryo? When that happens, we know the regulations. At the moment we are really, really far off from that point," Hanna said. However, they said the work could open the door to new ways to test the effect of drugs on pregnancies, better understand miscarriages and genetic diseases, and maybe grow transplant tissues and organs. "They are not identical. There are differences from human embryos, but still, this is the first time, if you open an atlas or a textbook, you can say - yeah I can really see the similarity between them," said Hanna. "In about 1 percent of the aggregates we can see that the cells start differentiating correctly, migrating and sorting themselves into the correct structure, and the farthest we could get is day 14 in human embryo development," he said. Their next goal, Hanna said, is to advance to day 21 and also reach a threshold of a 50 per cent success rate. Magdalena Żernicka-Goetz, a professor of development and stem cells at the University of Cambridge, said the study joins six other similar human embryo-like models published from teams around the world this year, including from her lab. "None of these models fully recapitulate natural human development but each adds to ways in which many aspects of human development can now be studied experimentally," she said. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Lewis Hamilton cannot be blamed for considering a blockbuster switch to Red Bull following Mercedes’ failure to provide him with a winning machine, Christian Horner has claimed. Red Bull team principal Horner confirmed on Friday that Hamilton’s father Anthony made an inquiry about the availability of a seat alongside Max Verstappen at the grid’s all-conquering team. Verstappen has won the past three world championships, while Hamilton last took a victory at the penultimate round of the 2021 season in Saudi Arabia. “I have known Anthony Hamilton for 15 years and I don’t think he was enquiring about himself to come and drive,” said Horner of Anthony, who managed his son in the formative years of his career. “I don’t know who represents who, but with the surname you would think they are reasonably close. “Anthony is a good guy, a proud racing father and inevitably when drivers go through tough spots – and Lewis has not won a Grand Prix for two years – questions will be asked up and down the paddock. “Lewis is the most successful driver of all time and he hasn’t won a grand prix since 2021. You have not got to be a rocket scientist to work that out and I doubt I was the only one that an inquiry was made to.” Red Bull will head into the season finale having failed to win just one of the 21 rounds so far. Verstappen has triumphed on 18 occasions – a record for any driver during a single campaign. Hamilton’s Mercedes team are in a state of flux, but the seven-time world champion signed a two-year deal with the Silver Arrows, worth £100million, in August. Sergio Perez is contracted to Red Bull for 2024. On Thursday, Hamilton denied seeking a move to Red Bull and claimed it was instead Horner who approached him. “I have checked with everyone in my team and nobody has spoken to them. However, he (Horner) did reach out to me earlier on in the year about meeting up,” Hamilton said. Horner added: “It is entirely normal for drivers, drivers’ representatives and drivers’ parents to have different conversations during the year. “There was never a seat available and there was never any engagement. There are many drivers we hear from during the course of the year. “We have not had any serious discussions with Lewis and there was never a seat available.” Read More George Russell fastest as rookies handed chance in first Abu Dhabi practice Class action lawsuit filed over farcical start to Las Vegas Grand Prix Toto Wolff fuelled by ‘personal anger’ to help Lewis Hamilton win eighth title On this day in 2010: Sebastian Vettel becomes youngest ever F1 world champion F1 Abu Dhabi Grand Prix LIVE: Practice updates and times at Yas Marina Christian Horner reveals talks with Lewis Hamilton’s father over Red Bull seat

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