NieR:Automata is heading to the Nintendo Switch on Oct. 6, 2022.

The Rays took the first of three from the Rangers in a battle of the two best teams in the American League.Saturday will be another big test for each team, but possibly more for the Rangers, who will start AL Cy Young candidate Nathan Eovaldi against the best lineup in baseball in the Rays. Can ...

Scientists have grown human kidneys in pigs, for the very first time. Researchers at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences and Wuyi University created human-pig chimeric embryos containing a combination of human and pig cells. When they transferred into 13 surrogate pig mothers, they developed kidneys that contained mostly human cells at a rate of 50 to 60 per cent, giving hope for potential transplants in the future. “Rat organs have been produced in mice, and mouse organs have been produced in rats, but previous attempts to grow human organs in pigs have not succeeded,” said the senior author Liangxue Lai. “Our approach improves the integration of human cells into recipient tissues and allows us to grow human organs in pigs.” The kidneys were not entirely human as they included vasculature and nerves made mostly from pig cells, meaning they could not be used for transplantation in their current form, but it is still a pretty impressive step. And apart from the kidneys, the embryos were dominated by pig cells, with very few human cells in the brain or central nervous system. Making brains using human and pig cells is very controversial for ethical reasons, so there are tight regulations for this kind of research. Meanwhile, pig cells tend to outcompete human cells during development, so previous experiments have created embryos that are almost entirely pig. The latest work, published in Cell Stem Cell, overcame this by genetically engineering a single-cell pig embryo so that it lacked two genes needed for kidney development. This created a gap within the embryo that could be filled by human cells. “We found that if you create a niche in the pig embryo, then the human cells naturally go into these spaces,” said Prof Zhen Dai of Guangzhou Institutes of Biomedicine and Health, another senior author. The scientists said that being able to incubate a fully human kidney inside a pig would be likely to take many years. “We would probably need to engineer the pigs in a much more complex way and that also brings some additional challenges,” said Miguel Esteban, also of the Guangzhou institute and a senior author. A central challenge would be to allow human nerves and vasculature to develop within the target organ without nerve cells developing in the central nervous system that could lead to a humanised brain. “Even theoretically it’s not clear how you’d do that,” said Ilic. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Grains prices will once again be a central focus in commodities markets this week after the latest talks

Make this in summer when the tomatoes are at their best,” suggests Imad Alarnab. “The better the tomato, the better this will taste, so splash out and get the good ones.” Heritage tomato, fennel and dukkah salad Serves: 2 as a main or 4 as a side Ingredients: 1 fennel bulb 2 tbsp olive oil 1 tsp za’atar 300g assorted heritage tomatoes, cut into chunks 2 tbsp good-quality extra virgin olive oil Grated zest and juice of ½ lemon 2 tbsp dukkah 150g soft goat’s cheese Small handful of fresh tarragon leaves Salt Method: 1. Preheat the oven to 200C/fan 180C/gas 6. 2. Cut the fennel bulb into 6-8 wedges, depending on how large your fennel is. Toss in the olive oil, za’atar and salt to taste, place on an oven tray and roast for 25-30 minutes until soft, slightly crisp and golden. Set aside to cool slightly. 3. Toss the tomatoes in a little salt and the extra virgin olive oil, lemon zest and juice, and dukkah. Roughly crumble the cheese and place on a large serving plate, followed by the roasted fennel and then the tomatoes. Finish with the tarragon leaves. Imad’s Syrian Kitchen by Imad Alarnab (HQ, £26). Read More The National Portrait Gallery’s new restaurant is fabulous upgrade The dish that defines me: Alex Outhwaite’s Vietnamese bun cha 3 TikTok-approved recipes for picnic season Imad Alarnab: In Calais’ Jungle refugee camp, food restored our faith It’s easier to make baklava at home than you might think Make this Middle Eastern lamb shoulder for your next Sunday roast

Unai Emery praised the versatility of Matty Cash after the Poland international’s first Aston Villa goals in over a year helped them to a 3-1 win at Burnley. There was speculation Cash could be on his way out of Villa Park this summer, but the 26-year-old showed what an asset he can be with two goals in the opening 20 minutes of his 100th Villa appearance, twice threatening to make it a hat-trick. Cash replaced Leon Bailey on the right wing in the only unenforced change to the Villa side that beat Hibernian 5-0 in the Europa Conference League play-off in midweek – Robin Olsen replaced the injured Emi Martinez in goal – and caught the eye with an energetic display. “He’s versatile, he played before as a winger, he’s playing with us in a back four sometimes, sometimes lower, but we used him in pre-season playing higher, as a winger,” Emery said. “He helped us a lot today defensively and offensively and then he used the moment to remember when he played more at Nottingham Forest as a winger. His two goals were a good example for us but we know he can be versatile.” That versatility can be key for Villa at a time when injuries are limiting Emery’s options. The Spaniard named only eight players, two of them goalkeepers, on the bench, and admitted Villa could be active again before the transfer window closes. “There are still four days to finish the transfer window and we have to be ready,” Emery said. “We have to be ready in case someone is leaving, in case we have a good opportunity to add another player with us. “Always in my teams I was working and I am ready at the end if someone can come with us or someone can leave.” Villa’s biggest move in the market so far has been the signing of Moussa Diaby from Bayer Leverkusen for a reported £51million. The France forward combined with Cash to create Villa’s second of the afternoon before his 61st-minute strike, his second Villa goal, settled it after Lyle Foster got Burnley back into the match. Learning comes at a price in the Premier League Vincent Kompany “His adaptation is going fast but he needs this adaptation each match for him to know better his team mates and then where in our structure is his best position,” Emery said. “He is a player who is versatile as well. “It’s very important for him and for the team, his capacity to assist, to score goals.” Defeat leaves Burnley without a point after their opening two Premier League matches, both home defeats after the 3-0 loss to Manchester City a fortnight ago. “Learning comes at a price in the Premier League,” manager Vincent Kompany said. “I didn’t think we started the game badly, we had moments, we just didn’t manage to get a real grip on the game and there was always the threat of Aston Villa counters. “In the second half we built momentum, the goal helped us for that definitely, and just at the peak of that momentum we conceded the goal and that was a little bit the story of the game.” Kompany handed a debut to Hannes Delcroix, meaning six of the starting XI were new signings this summer. The manager admitted there will be a bedding-in period. “It’s a conscious choice,” he said. “You look at the bottom of the league and you find every flavour – teams that are settled and have not changed and teams that have changed. “For us, we want to move forward. I’ve seen enough in our team to know that we make a game out of games. Every game there is something for us, and if that continues I believe we’ll have enough results.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live England confirm Jonny May as Anthony Watson’s replacement in World Cup squad Danni Wyatt stars as Southern Brave beat Northern Superchargers in Hundred final Cian Healy left out of Ireland’s 33-man Rugby World Cup squad due to injury

Stephen Colbert announced the cancellation of the week's episodes due to his recent surgery

The popular Chinese TikTok series amplifies nationalist calls for the return of the country's treasures.

After the Welsh Rugby Union's decision to stop playing ‘Delilah’ at Wales matches, Sir Tom Jones has lived up to his promise to keep belting it out for fans at his gigs.

Fans inform Megyn Kelly they will still vote for Donald Trump even after his nomination is rescinded

Michael Carrick will have no regrets that his illustrious playing career is over as he attempts to guide Middlesbrough through the biggest game of his managerial reign to date. The 41-year-old played in Champions League and FA Cup finals and won five Premier League titles during a trophy-laden spell at Manchester United, but on Sunday will stand on the touchline at Coventry as his Boro side looks to take a significant step towards the Sky Bet Championship play-off final. Carrick chose to launch the latest phase of his football journey in earnest when he took up the role of head coach at the Teesside club in October last year and – while the highs of his playing career remain at the forefront of his memory – he is finding the task hugely rewarding. Asked if he would rather be pulling on his boots on Sunday, he replied with a smile: “Those days are gone. “There are pluses and minuses comparing both. It’s incredible when you’re playing and you’re achieving and you have that sense of directly influencing a game like that and sensing the occasion. “But certainly being in the position I am and having that influence and being able to guide and steer things in a direction I’m comfortable with can be very rewarding.” In less than seven months under Carrick, Boro dragged themselves from 21st place to fourth and could now be just three games away from the Premier League, something which was far beyond the former England midfielder’s thinking the day he arrived at the Riverside Stadium. However, the excitement that rise has prompted is not lost on him. Carrick said: “I didn’t really have a target or a goal when first came in, it was more a case of trying to improve, trying to develop the team and seeing where it took us. “To see the children coming up to me in the street and chasing me on bikes down the street when I’m trying to go for a run and that energy and excitement that they’ve got is fantastic to see, and it’s how it should be.” Carrick started his path to a career in professional football at Boro as a schoolboy and rose to prominence at West Ham and then Tottenham. But it was under the tutelage of then United boss Sir Alex Ferguson that he honed his skills at the elite level and the Scot, who won 38 trophies during his time at the Old Trafford helm, remains a source of help and advice. Asked if he would speak to Ferguson in the run-up to the game, Carrick said: “Probably at some point. I speak to him quite a bit – not all the time, but quite a bit on and off. “He’s always there if I need to speak to him and giving me little bits of help along the way. “But it’s more of a friendship thing. It’s nice to have that ability to have somebody like that to speak to, of course it is.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Man Utd boss Marc Skinner fires FA Cup final warning to favourites Chelsea Eurovision has disrupted Man City’s schedule, Pep Guardiola says Everton have their edge back at the right time in relegation battle – Sean Dyche

Chrissy Teigen raises breast cancer awareness with cheeky caption as she undergoes mammogram screening