STOCKHOLM (Reuters) -Sweden's national security service raised its terrorist alert to the second-highest level on Thursday and warned that the

One year after the Qatar World Cup, billboards emblazoned with the tournament's official slogan, "All is now," still...

Chelsea have agreed a deal to sign midfielder Moises Caicedo from Brighton and Hove Albion, with the fee set to be a British transfer record. On Sunday evening, Sky Sports reported that Chelsea will pay £115m for the Ecuador star, eclipsing the previous mark set when they bought Enzo Fernandez from Benfica for £106.8m in January. The report stated that Caicedo would sign an eight-year contract, with the Blues paying £100m plus £15m in add-ons. Chelsea had to increase their bid for Caicedo several times but eventually clinched a deal after Liverpool had also reached an agreement with Brighton at £111m pounds. The 21-year-old Caicedo still had four years to run on his Brighton contract but told the club he wished to leave and made it clear he wanted to go to Stamford Bridge rather than Anfield. He signed for Brighton in February 2021 for a reported fee of £4.5m and was loaned to Belgian club Beerschot in August that year. He was recalled by Brighton in January 2022 after 14 appearances in Belgium and, under coach Roberto De Zerbi, Caicedo blossomed in midfield last season. Chelsea are also looking to strengthen their forward line under new boss Mauricio Pochettino after suffering injuries and key departures including Kai Havertz who signed for Arsenal and Christian Pulisic who left for Serie A side AC Milan. The club’s new French striker Christopher Nkunku, brought in for around £60m, will be out for a “prolonged period” after having surgery on a knee injury, although another new signing Nicolas Jackson impressed in his absence during the Blues’ Premier League opener. Chelsea, who finished 12th last season, began their campaign with a 1-1 draw at home to Liverpool on Sunday. Read More Chelsea and Liverpool serve up entertaining glimpse of football without defensive midfielders Last season is a long time ago – Mauricio Pochettino looks forward with Chelsea Chelsea-Liverpool chaos was the perfect result for one team: Brighton

Tyler O’Neill and Nolan Gorman hit early two-run homers to spoil Michael Soroka’s promotion to Atlanta and the St. Louis Cardinals beat the Braves 10-6

Traders are adding to bets that the Bank of England’s unexpectedly large interest-rate hike won’t be its last.

Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Canadian Michael Woods delivered an impressive solo effort to claim the biggest success of his career at the top of a legendary climb of the Tour de France

Second-seeded Florida has its most talented pitching staff since winning the program’s lone national title in 2017

Marcus Riley returned the game’s opening kickoff 96 yards for a score, Jeremy Moussa threw two touchdowns, and Florida A&M beat Jackson State 28-10 in the Orange Blossom Classic

The Apple iPad doesn't get the credit it deserves for essentially creating the modern tablet

With a World Cup on the horizon, Megan Rapinoe made it official a day before the USWNT play Wales in the World Cup send-off match that she'll say farewell to the game at the conclusion of the 2023 NWSL campaign.U.S. soccer without Megan Rapinoe will just not be the same. She is not just a s...

Mounting climate risks, illustrated by the extreme heat, wildfires and floods that ravaged parts of Europe this summer, could hurt the region's economy as soon as this year, the European Commission warned Monday.