Daniel Day-Lewis has successfully kept a low profile since he retired from acting in 2017

DEDHAM, Mass. A Massachusetts judge on Wednesday dismissed a criminal case charging former Roman Catholic Cardinal Theodore McCarrick

When Italy's Prime Minister Giorgia Meloni made an official visit to the crime-ridden Neapolitan suburb of Caivano last week, she promised a "radical reclamation" of a territory she admitted "the state had failed."

The president of Texas A&M University has resigned after a Black journalist’s celebrated hiring at one of the nation’s largest campuses unraveled over criticism of her diversity and inclusion work

It is Wednesday, my dudes, and it's time for Wordle! And as always, we're here

Google says it has made a significant step in identifying disease-causing genes, which could help spot rare genetic disorders. A new model named AlphaMissense is able to confidently classify 89 per cent of all possible “missense” variants in genes, identifying whether they are likely to cause diseases or benign. That compares with just 0.1 per cent of all missense variants that have been confidently classified by human experts. Missense variants happen when a single letter is substituted in the DNA, which in turn leads to proteins with a different amino acid. That small change can have significant effects – Google likened it to the way that changing a letter in one word can change the meaning of the whole sentence. Most of those variants are benign: the average person has more than 9,000 of them. But some of them can be disastrous, leading to rare genetic diseases. The new AlphaMissense looked at existing information about missense variants, and how commonly they are seen in humans and closely-related primates. It looked for those that were rarely seen, classifying them as pathogenic, and from that was able to use that information to analyse other protein sequences – giving not just a verdict on whether they were likely to cause problems, but also how confident it was. Experiments, conducted by humans, which look to find those mutations are expensive and slow: they require people to examine each unique protein and designed separately. Google says that the new system means that researchers can “preview” those results for thousands of proteins at a time, helping them decide where to focus. The company has used its systems to release a vast catalogue of “missense” mutations, so that researchers can learn about what effect they have. In some cases, those variations can lead to conditions such as cystic fibrosis, sickle-cell anaemia, or cancer, and understanding them could be key to researchers studying ways to treat or prevent those diseases. It is just the latest health breakthrough from Google’s Deepmind division, which is looking to use artificial intelligence to both identify and treat a variety of conditions. The new system was built on AlphaFold, the breakthrough model that helped unfold proteins, the building blocks of life. The research is described in a new paper, ‘Accurate proteome-wide missense variant effect prediction with AlphaMissense’, published in the journal Science. The catalogue is being made “freely available to the research community”, Google said, and the company will release the code behind the AI system. Read More BBC removes some Russell Brand content as monetisation suspended on YouTube Google Bard can now link to Gmail and other apps to help with responses Long-form video content is here to stay, says YouTube UK boss

A Bob Marley biopic is making its way to the big screen more than 40 years after his death -- and a trailer just dropped.

The Pokémon GO Evolving Stars event includes Collection Challenges for Eevee, Sinnoh Pokémon and Unova Pokémon, plus a trade challenge.

SBI Holdings Inc., a Japanese venture capital group, plans raise to raise $80 million for Novastar Ventures to

By Ludwig Burger and Maggie Fick (Reuters) -The British government will launch a pilot programme to explore how new injectable

Kai Cenat and musician Offset are featured in a promo for the game

CD Projekt Red have announced that their new anime series, Cyberpunk: Edgerunners will be heading to Netflix this September.