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Sepsis is an illness that affects nearly 50 million people worldwide each year, with around 11 million deaths attributed to the condition. In the United States, at least 1.7 million adults in the US develop sepsis annually, and nearly 270,000 die as a result, the Centres for Disease Control and Prevention (CDC) says. It affects 245,000 people in the UK each year, with around 48,000 deaths, according to the UK Sepsis Trust. World Sepsis Day commemorated on 13th September every year, strives to raise global awareness of the life-threatening condition. The day is seen as “an opportunity for people worldwide to unite in the fight against sepsis,” the Global Sepsis Alliance says. Here is everything you need to know about sepsis: What is sepsis? Sepsis Research says when the condition strikes, the immune system “overreacts” and begins to attack the infection and everything else around it “including the body’s own tissues and organs.” “Any type of infection — bacterial, viral or fungal — can lead to sepsis,” it adds. When sepsis occurs, it can cause inflammation and cause blood clotting around the body, if it does not get treated, it can result in death, organ failure and tissue damage, CDC says. Sepsis cannot be caught from another person, the NHS explains. What are the symptoms? The World Health Organisation (WHO) explains that the condition is a “medical emergency,” so if you think a person is exhibiting signs of sepsis or if you are showing signs – make sure you call 999 or go to the emergency room immediately. According to WHO, common signs and symptoms include: • Fever or low temperature and shivering • Confusion • Difficulty breathing • Clammy or sweaty skin • Extreme body pain or discomfort • High heart rate, weak pulse or low blood pressure • Low urine output Symptoms in children include: • Fast breathing • Convulsions • Pale skin • Lethargy • Difficulty waking up • Feeling cold to touch What are the causes? The Mayo Clinic says any type of infection can lead to sepsis and those that more commonly cause the condition include infections of: • Lungs, such as pneumonia • Kidney, bladder and other parts of the urinary system • Digestive system • Bloodstream • Catheter sites • Wounds or burns “Sepsis often presents as the clinical deterioration of common and preventable infections such as those of the respiratory, gastrointestinal and urinary tract, or of wounds and skin. Sepsis is frequently under-diagnosed at an early stage - when it still is potentially reversible,” the Global Sepsis Alliance says. Who is most at risk? The people most at risk of the condition, according to Mayo Clinic, are: • People with lower immune response, such as those being treated for cancer • People with human immunodeficiency virus (HIV). • People with chronic diseases such as diabetes kidney disease or chronic obstructive pulmonary disease (COPD). • people who are in intensive care or longer hospital stays. • People over the age of 65 • Infants How many cases are there globally? The WHO says a scientific publication estimated that in 2017 there were 48.9 million cases and 11 million sepsis-related deaths worldwide, which accounted for almost 20 per cent of all global deaths. That same year, almost half of all global sepsis cases occurred among children with an estimated 20 million cases and 2.9 million global deaths in children under 5 years of age. How can it be prevented? The Global Sepsis Alliance says the best to to avoid sepsis is by preventing infection. This can be done by undergoing vaccinations, ensuring that you only come into contact with clean water, washing your hands properly and if you are giving birth - making sure it is in a clean and sterilised environment. Can sepsis be treated? Sepsis can be treated with appropriate treatment such as antibiotics – this should be given as soon as possible. The CDC says sometimes “surgery is required to remove tissue damaged by the infection”. “Antibiotics are critical tools for treating life-threatening infections, like those that can lead to sepsis,” the CDC adds. Read More 5 things everyone needs to know about eczema 13 potential cancer symptoms you should get checked out How can I improve my teenager’s low mood? Duran Duran’s Andy Taylor says he’s ‘asymptomatic’ after end-of-life diagnosis Nine hours of parallel surgery: how Britain’s first womb transplant was carried out Bursts of activity that make you huff and puff ‘linked to reduced cancer risk’

Elon Musk, the owner of X – the company formerly known as Twitter – said on Saturday that the social media platform “may fail” as a new glitch wiped out most pictures tweeted before December 2014. “The sad truth is that there are no great ‘social networks’ right now. We may fail, as so many have predicted, but we will try our best to make there be at least one,” Mr Musk posted on X. Since his take-over of the company for $44bn, the multibillionaire has tried to shake things up, introducing radical new changes to the platform, from laying off over three-fourths of Twitter’s workforce to his latest statement that the platform’s feature to block other user profiles would be removed. The platform, being rebranded as X, has also suffered blackouts and glitches in recent times with the latest one appearing to affect tweets with pictures and links published prior to December 2014. X appeared to have problems displaying old posts that came with attached images or hyperlinks converted using Twitter’s built-in web link shortener. Among the images initially lost was the famous “most retweeted” selfie from the 2014 Oscars by the event’s host and comedian Ellen DeGeneres. This image has since been restored, but most old tweets before December 2014 have broken short links instead of the actual media or links. “More vandalism from Elon Musk. Twitter has now removed all media posted before 2014. That’s - so far - almost a decade of pictures and videos from the early 2000s removed from the service,” Brazilian YouTuber Tom Coates posted on Twitter. The glitch comes after Mr Musk’s X intentionally slowed down access to the sites of rival social media platforms such as Threads, Facebook, and Instagram, as well as those of news organisations like New York Times last week. X seemed to add a delay of about five seconds when people clicked on links to go elsewhere on the web. There are speculations that the latest glitch preventing access to old images could be due to X trying to recover more server space, but this might also not be an intentional move carried out for cost-cutting purposes. Some people also appear to be able to view their old images back again, but it remains unclear why the glitch occurred in the first place. Read More Musk vows to remove blocking function from X/Twitter as new logo debuted Elon Musk says ability to block other X accounts may be removed in future Elon Musk’s X now sorts posts on accounts based on number of likes, not by chronology Musk vows to remove blocking function from X/Twitter as new logo debuted X now sorts posts on accounts based on number of likes, not by chronology Musk’s Twitter takeover sparks mass exodus of climate experts

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