Retired Big 12 commissioner Bob Bowlsby will return to Northern Iowa to serve as interim athletic director

By Tom Westbrook SINGAPORE Asian equity markets struggled for direction on Tuesday as the bounce from Beijing's efforts

Industrial demand for gas in Europe’s largest nations remains depressed despite lower prices, as an economic slowdown weighs

Paul-Henri Mathieu has been named France’s Davis Cup captain and he’ll also lead the men’s national tennis team at next year’s Olympics in Paris

Claudia Morales, the girlfriend of social activist Ryan Thoresen Carson, 32, was unable to identify the suspect who stabbed her boyfriend to death

Elon Musk said Tesla Inc. is still planning a vehicle factory in Monterrey, Mexico, but isn’t ready to

Scientists in Israel have created a model of a human embryo from stem cells, without using sperm, eggs or a womb. A team at Israel's Weizmann Institute of Science made the model, which resembles an embryo at day 14, when it acquires internal structures but before it lays down the foundations for body organs, and the work was published in the journal Nature. But the scientists involved said it would take a long time yet to create an embryo from scratch. Team leader Jacob Hanna said the team took stem cells derived from adult human skin cells, as well as others cultured in the lab, then reverted the cells to an early state.They then manipulated them to make a model of an embryo, rather than an actual or synthetic one. "The question is, when does an embryo model become considered an embryo? When that happens, we know the regulations. At the moment we are really, really far off from that point," Hanna said. However, they said the work could open the door to new ways to test the effect of drugs on pregnancies, better understand miscarriages and genetic diseases, and maybe grow transplant tissues and organs. "They are not identical. There are differences from human embryos, but still, this is the first time, if you open an atlas or a textbook, you can say - yeah I can really see the similarity between them," said Hanna. "In about 1 percent of the aggregates we can see that the cells start differentiating correctly, migrating and sorting themselves into the correct structure, and the farthest we could get is day 14 in human embryo development," he said. Their next goal, Hanna said, is to advance to day 21 and also reach a threshold of a 50 per cent success rate. Magdalena Żernicka-Goetz, a professor of development and stem cells at the University of Cambridge, said the study joins six other similar human embryo-like models published from teams around the world this year, including from her lab. "None of these models fully recapitulate natural human development but each adds to ways in which many aspects of human development can now be studied experimentally," she said. Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Here's a breakdown of the Flash Sale promotion in MLB The Show 22 Diamond Dynasty.

By Michael S. Derby NEW YORK A default on U.S. Treasury debt would be a leap into the

A three-day search of a remote Portugal reservoir has resulted in the reported discovery of a “relevant clue” linked to the disappearace of Madeleine McCann. Officers concluded their search of the Algarve reservoir on Thursday, where key suspect Christian Brueckner reportedly visited “some days” after the three-year-old vanished on May 3, 2007. Using sniffer dogs and a tractor-based tree-cutter, authorities scoured Barragem do Arade reservoir in the Algarve - around 31 miles inland from where the McCanns were staying in the Praia de Luz resort. Police in Portugal said: “[The search] resulted in the collection of some material that will be subject to the competent expertise. The material collected will be handed over to the German authorities.” During the search, a “relevant clue” was found which led to police officers concentrating on a specific paper, according to the Correio de Manhã newspaper. Brueckner has denied any involvement and is currently behind bars in Germany for raping a 72-year-old woman in the same part of Portugal. Read More Madeleine McCann police give update as they end search of Portugal reservoir Police flatten area of woodland and dig holes in Madeleine McCann searches Who is Christian Brueckner? Madeleine McCann suspect and the accusations against him Madeleine McCann case: Timeline of the missing child’s disappearance

Ilia Topuria has a question for you. Actually, he has a few. “Do you know how good I am?” is the first. Initially, I’m not quite sure whether I should answer on your behalf. He asks again. “Do you know how good I am?” To my relief, he quickly follows up. “I can submit him, I can knock him out. I can do with him whatever I want.” The German-born Georgian, fighting out of Spain, is not actually talking about Josh Emmett – whom he faces in a UFC Fight Night main event on Saturday. Rather, he is reflecting on his win against Bryce Mitchell. In December, Topuria submitted the submission specialist to the surprise of many, and that is why he asks: “Do you know how good I am?” It is also why he asks: “Do you know how dangerous my takedowns are, how dangerous my ground game is?” I had entered our interview presuming I would be asking the questions, but by this point, the unbeaten featherweight might have overtaken me. “I don’t care what people say about me,” he adds. “People were talking like: ‘He’s good on the ground’. I’ve been a black belt since I was 20 years old. For me, there’s no surprise if I submit Bryce Mitchell or anyone in my division. I know that I can finish anyone. Brazilian jiu-jitsu grappling is my world.” As the conversation turns to Emmett, the next obstacle in Topuria’s way as he hones in on a title shot, the 26-year-old has even more questions. “With Josh, people say: ‘His right hand is so dangerous.’ Do you know how dangerous my right hand is? Do you know how dangerous my left hand is?” The answers to all of Topuria’s questions are found fairly easily, so any frustration he has towards those fans who have missed them is understandable. Twelve of the Georgian’s 13 professional wins have coming via stoppage – eight by submission and four by knockout. Nine months before Topuria entered the featherweight top 10 with his arm-triangle choke against Mitchell, he knocked out Jai Herbert on the Briton’s home soil in London. After surviving a knockdown from a picture-perfect head kick, Topuria melted Herbert with a singing left hook to the liver and a molten right hand to the chin. While that bout took place at lightweight, it registered as a message to all UFC featherweight contenders when Topuria later dropped into the division. And, now done asking questions, Topuria has a message for you: “Shut up. Just watch the fight and enjoy.” Topuria will certainly enjoy his clash with Emmett in Jacksonville this weekend, as he looks to hand the American, 38, a second straight defeat, four months after Emmett lost to Yair Rodriguez with the interim featherweight belt on the line. “When I’m in the ring, I’m really happy and really thankful to God,” Topuria tells The Independent, “because I asked him to put me in this position. It was my goal to become a UFC champion, and this is the way I have to pass. When I go inside the cage, I feel very happy to have that opportunity, because I have the chance to fight for my dreams, and right now there are a lot of people in hospitals, [fighting] for their lives. “I’m working for my happiness every day. When I wake up, I’m not happy just for something I did in the past; I can’t live off that for my whole life. I’m just focused on myself and achieving my goals. I don’t care about anyone else – just me, my family, and my friends. That’s it.” Among the small group dearest to Topuria is his three-year-old son – already a “man”, in his father’s words. “He knows [what I do], he knows,” Topuria says. “He calls me every day, supporting me. He speaks perfectly. He’s a man. I don’t know if he’s gonna do MMA. If that’s the call [he makes], I’ll support him in anything he chooses in this life. “If he wants to fight, I’m gonna support him; if he wants to... I don’t know... study, I’m gonna support him. If it makes him happy, I don’t care. Go for that, because in this life, people are always looking for success. What’s success for me? Success is when you’re happy with yourself, that’s it.” In that sense, Topuria is already a very successful man. Winning the UFC featherweight title would only reaffirm that fact. Click here to subscribe to The Independent’s Sport YouTube channel for all the latest sports videos. Read More Topuria vs Emmett live stream: How to watch UFC Fight Night online and on TV this weekend Conor McGregor complains as his team lose yet again on The Ultimate Fighter How Ciryl Gane’s Jon Jones dream turned into a nightmare Topuria vs Emmett and full UFC Fight Night card this weekend What time does Topuria vs Emmett start in UK and US this weekend? How to watch Topuria vs Emmett online and on TV this weekend

The 2023 CONCACAF Leagues Cup, a month-long tourney will halt all league play across North America beginning July 21 through a final match scheduled for August 19.