Centenarians tend to have lower levels of glucose, creatinine and uric acid from their sixties onwards, according to the largest study of its kind that may lead to a simple blood test to predict a person’s chance of reaching 100. The research, published on Monday in the journal GeroScience, is the biggest to date to measure and follow up the levels of different molecules in the blood of people born between 1893 and 1920. Scientists, including those from Karolinska Institutet, assessed the data on blood molecules from over 44,500 Swedes who underwent clinical testing between 1985 and 1996 and followed up till 2020. They focused specifically on people born between 1893 and 1920, who were between 64 and 99 years old when their blood samples were first tested, and followed them up as they grew closer to 100 years of age. About 1,200 individuals in the study, or about 2.7 per cent of the participants, reached 100. Researchers compared this subset’s data with those of their peers who were younger than them. The analysis found 12 blood-based molecules associated with metabolism, inflammation as well as liver and kidney function, that were also linked to ageing or mortality in previous studies. These molecules included total cholesterol and glucose as markers of metabolism, uric acid indicating inflammation levels, enzymes indicative of liver health and creatinine as a measure of kidney health. Researchers also looked at albumin and iron levels in the blood. Except for a liver enzyme and albumin, all other molecules were found linked to the likelihood of a person becoming a centenarian. Those with increased levels of total cholesterol and iron had a greater likelihood of becoming centenarians compared to those with lower levels. However, for molecules including glucose, creatinine, uric acid, and liver enzymes, lower levels were associated with higher chances of living past 100. “We found that, on the whole, those who made it to their hundredth birthday tended to have lower levels of glucose, creatinine and uric acid from their sixties onwards,” researchers wrote in The Conversation. “Very few of the centenarians had a glucose level above 6.5 earlier in life, or a creatinine level above 125,” they said. While the differences found in the study between groups were small in some cases, researchers said the findings still suggest a “potential link” between metabolism, nutrition and longevity. However, the study falls short of recommending lifestyle factors or genes responsible for these blood molecule levels. “While chance likely plays a role for reaching age 100, the differences in biomarker values more than one decade prior death suggest that genetic and/or lifestyle factors, reflected in these biomarker levels may also play a role for exceptional longevity,” scientists wrote in the study. “However, it is reasonable to think that factors such as nutrition and alcohol intake play a role. Keeping track of your kidney and liver values, as well as glucose and uric acid as you get older, is probably not a bad idea,” they said. Read More Good financial planning could increase life expectancy, study suggests Scientists find gene that grants long life – and successfully test it on another species Scientists extend mice lives by connecting their blood to young ones

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Ukrainian soldiers fighting off Russian attacks in the eastern battlefield achieved “partial success” in the past 24 hours while troops in southern Ukraine inflicted over a hundred Russian casualties, officials said as the war was close to clocking 600 days. The troops secured partial success near Andriivka, a small Ukrainian village captured last month along with the nearby locality of Klishhiivka, said Ilia Yevlash, a spokesperson for Ukraine‘s eastern group of forces. "We are repelling constant attacks near Klishchiivka and Andriivka,” the spokesperson told national television. "Every day we are making headway in the Bakhmut sector. We are talking about hundreds of metres at a time that we are liberating from our enemies and strengthening our positions. It is, however, too early to talk about achieving concrete goals,” he said. The “partial” headway in territorial advance was also reported in southern Ukraine by general Oleksandr Tarnavskyi, commander of forces in the south. “We have partial success west of Verbove. During the past 24 hours, the enemy carried out eight airstrikes, 18 combat encounters, and also launched 455 artillery barrages,” the top military official said on his Telegram channel. Verbove is one of the cluster of villages that Ukraine is targeting, with the larger town of Tokmak as the next large target. The Ukrainian units of rocket troops and artillery from the Tavria Air Defence Forces launched 795 fire missions during the day, he said. “The total losses of the enemy amounted to 147 people,” he said but did not give details about the injuries, deaths, and capture of Russian soldiers as prisoners of war. Three Russian ammunition depots were also bombed, along with two tanks and an artillery system, he said. This comes amid first signs of deterioration in battlefield conditions due to weather as Russian military bloggers said rainfall has worsened visibility in southern Ukraine. Experts monitoring the war said changing weather conditions will hinder the reconnaissance drone operations on both sides. “One Russian milblogger claimed that the ground has become muddy and obstructs tracked vehicle movement, though another milblogger claimed that the ground has not yet become muddy enough to inhibit vehicle movement,” said the Institute for the Study of War in its latest assessment on Monday. It added that exact conditions likely vary along the frontline, though weather conditions are generally worsening.It cited Yevlash’s report stating that the Russian forces are relying less heavily on aviation and drone activity in the Kupiansk-Lyman direction due to heavy rainfall. The Russian accounts of fighting claimed its forces thwarted Ukrainian attacks near Bakhmut and inflicted heavy casualties in strikes on Ukrainian positions outside the city. Now on the edge of entering its fifth month, Ukraine’s counteroffensive aims to secure control of areas around Bakhmut in order to recapture the town, which was seized by Russian forces in May after months of heavy battles. Read More Ukraine-Russia war – live: It is in Russia’s interests to inflame war in the Middle East, says Zelensky Zelensky says Russia trying to incite war in the Middle East Satellite images show spike in border activity as North Korea ‘supplies weapons to Russia’ for Ukraine war Ukraine repels Russian attacks on five fronts as Putin resorts to old weaponry and reserves Russia reports coolant leak in backup line at space station and says crew not in danger