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LOS ANGELES--(BUSINESS WIRE)--Jun 21, 2023--

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Our canine companions could soon be enjoying much longer lifespans, if a drug which claims it can extend dogs’ lives eventually gets approved. The drug, made by a tech firm in California, just cleared a vital hurdle to doing just that, after it got partial approval by regulators in the US. Loyal, a San Francisco-based company founded in 2020, has been researching how it can increase dogs’ lifespans – in particular larger breeds, which tend to die younger. Large and “giant” breeds tend to live to between eight and 12 years. Smaller dogs, such as Chihuahuas, can keep going to the ripe old age of 20. Loyal’s main product, the catchily-titled LOY-001, is designed not only to extend dogs’ lives but also maintain their quality of life. Now, it has passed the “reasonable expectation of effectiveness” test, set by regulators at the US’ Food and Drug Administration. Loyal’s chief executive, Celine Halioua, said: "Loyal was founded with the ambitious goal of developing the first drugs to extend healthy lifespan in dogs. "This milestone is the result of years of careful work by the team. We'll continue to work just as diligently to bring this and our other longevity programs through to FDA approval." Selective breeding of dogs has caused higher levels of hormones which help the animals grow faster. That is also believed to reduce their lifespan, the company said. Big dogs tend to have more of this hormone than their smaller counterparts. Animal rights activists are not yet convinced. Some experts fear it will only serve to extend animals’ suffering. Loyal, on the other hand, says the drug aims to treat doggy diseases which are associated with ageing through preventing them, rather than waiting for the animals to get sick before treating them. The company said that the drug could be available to US customers as early as 2026. So that’s plenty of time for walkies between now and then. How to join the indy100's free WhatsApp channel Sign up to our free indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

England had covered the gaps, they had filled the holes. They had adjusted, adapted, repositioned, created a new formation, and reached a first World Cup final. Then England changed again. Down 1-0 at half time in the World Cup final, Sarina Wiegman went for a last roll of the dice, a double substitution that saw Alessia Russo and Rachel Daly brought off and Lauren James and Chloe Kelly come on. That 3-5-2 that was England’s revelation of the tournament, that changed their World Cup? It was binned. England went back to 4-2-3-1. They disposed of the wing-backs and brought on the wingers. They stopped pressing Spain and abandoned their plan. With it, and for the first time at the World Cup, the Lionesses did not find the change that was required. James and Kelly brought moments of improvement, but the truth is that England were at their most dangerous when Lauren Hemp and Russo were combining as a front two. Hemp’s switch to a central role took away the threat that was everywhere in the first half and left Wiegman searching for something else. On came Beth England. Up went Millie Bright. But this was a situation England could not overcome. In a tournament that has been defined by England’s ability to adapt and solve the problems they have faced, the changes that were required against Spain were a step too far. Mary Earps’s save from Jenni Hermoso’s penalty gave England some momentum, but this was a final that stuttered and in the second half never found its rhythm, where stoppages played into Spain’s hands and covered the defensive frailties they had previously shown through the tournament. “When Mary saved the penalty I thought we’d go on and score the goal,” Wiegman shrugged. “But we didn’t.” Wiegman felt England improved with the changes and they certainly played with a better balance. But by then the game had changed and in its final moments, Spain managed to stay in control. While England never found the right combinations, Spain never quite felt threatened. While England played with two systems, neither one quite arrived at the right time. Perhaps this was always the natural conclusion for a World Cup that hit its first hurdle in November when Beth Mead suffered a torn ACL, then when England lost Leah Williamson, and then Fran Kirby; the deflating end to a tournament where Wiegman has not had the same consistency or continuity of last summer’s Euros, and where winning the final was beyond the resilience of this side. Perhaps it’s also the rebalance from last summer’s quarter-final in Brighton, where Spain were the better team and lost after England found a moment of magic through Georgia Stanway’s equaliser. England couldn’t produce another one; despite the introductions of Kelly and James, England were at their most threatening when they played into an open, frantic match, even if it left them more vulnerable at the other end and, ultimately, led to Olga Carmona’s winning goal. It was a quality finish, the moment to crown Spain’s golden generation, a magnificent team of sharp passers and quick minds. Aitana Bonmati was the clear player of the tournament and no one will be surprised when the Ballon d’Or follows at the end of the year. They looked a class above England, but the regret is that a head coach who appears to have no impact on how his team plays in Jorge Vilda did not need to have a tactical approach to beat the Lionesses. England gave Spain what they wanted. Wiegman committed to a brave plan but it gave England a hard time. They had pushed high and pressed Spain, hoping to force the error, with Lucy Bronze and Daly defending as forwards as much as wingers, gambling on a misplaced pass. But Spain were too good. They responded by playing through England, isolating a back three that had found strength in its unity. Spain pulled an already stretched team further out of shape and created another problem for England to solve. Bronze’s misadventure then led to another one. As Carmona fired past Earps, Bronze immediately sank to the pitch, as if her legs had been cut from beneath her, the sort of reaction that told you everything about where the goal had come from. It was a run that was too ambitious when what England needed to do was move it faster. Bronze was crowded out, England were outnumbered, and suddenly it was left to Russo to follow Carmona’s run. That was a gap in the team that England could not cover. There had been such a fine balance to it, an open game where the first goal was always going to be crucial. While the final was goalless, England had chances that came from their high press and then found spaces to hit Hemp down the channels. But when Spain scored, the space vanished and Wiegman needed to try something else to protect her side, even if it meant England lost some of their unpredictability. To reach this stage was a triumph of the team’s approach and its mentality; a campaign that always managed to deliver answers. Eventually, and on the biggest stage of all, England were unable to find another. Read More England suffer World Cup heartache as brilliant Spain show Lionesses what’s missing Jorge Vilda: Spain’s World Cup coach at the heart of a civil war England v Spain LIVE: Women’s World Cup final result and reaction as Lionesses suffer heartbreak England players ‘heartbroken’ after World Cup final defeat to Spain England suffer World Cup heartache as brilliant Spain show Lionesses what’s missing Sarina Wiegman has already made the biggest decision of England’s World Cup

Wisconsin’s Republican-controlled Legislature is talking about impeaching a newly elected liberal state Supreme Court justice even before she has heard a case