By David Shepardson WASHINGTON General Motors on Tuesday said it was investing $920 million to expand operations at

DETROIT--(BUSINESS WIRE)--May 22, 2023--

Barcelona sporting director Deco speaks of the chances of Joao Felix and Joao Cancelo joining permanently and whether Ansu Fati will return to the club following his loan spell at Brighton.

Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

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Controversial Adin Ross, a Kick streamer, loses thousands of dollars in a bet against Kai Cenat, one of Twitch's most well-known broadcasters

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Pep Guardiola claimed there is no pressure on Erling Haaland to score more goals after the Norwegian’s double sank Young Boys on Wednesday. Haaland struck twice in the second half as the holders claimed a hard-fought 3-1 win over the Swiss side in their Champions League Group G encounter on the artificial surface at Bern’s Wankdorf Stadium. The game had been in the balance after Meschack Elia had cancelled out Switzerland international Manuel Akanji’s opener with a superb strike. Haaland’s goals were his first in six Champions League games while his effort against Brighton on Saturday ended a three-game scoreless run – relative barren spells for a player who plundered 52 in total last season. Guardiola said: “There is the impression after last season that he has to score seven goals every single game. That is impossible. “But he is scoring a lot of goals and if people want him to fail because he doesn’t score 50 goals it doesn’t matter. He is always there. “The second goal was really good and he had other chances. The important thing is to create them. “Maybe in the right moment of the season he will be there, better than now, but he has already scored a lot of goals and we are really pleased. “I’ve told him many times I don’t judge him for scoring goals, although I know he wants to score goals. He has the desire to improve and I don’t have doubts about that.” City’s victory, sealed with a Haaland penalty and a clever late finish, was their third in succession and took them a step closer to the knockout stages. They could reach the last-16 for an 11th consecutive season with a follow-up win over the same opposition at the Etihad Stadium in a fortnight. “The result was good and in general it was a really good performance,” said Guardiola, whose side had 26 attempts on goal. “We could have scored more goals but is the important thing is to create the chances.” Guardiola added that Phil Foden did not play because of a “small problem” while Julian Alvarez, who had a goal disallowed after coming off the bench, was not able to play the full game. Young Boys coach Raphael Wicky felt his side gave a good account of themselves. He said: “That courage and passion, we can be proud of what the team delivered, but you need a perfect game against a team like this. We couldn’t do it. “Perfect means taking your chances and not conceding from set-pieces. We’re disappointed with the result, but we can be proud of the team’s performance.” Read More Erling Haaland scores Champions League brace while PSG ease past AC Milan Former Everton boss David Moyes pays tribute to ‘wonderful man’ Bill Kenwright David Moyes hopes West Ham and Olympiacos fans behave in Greece Moeen Ali eager to get anxious England playing with a smile again Esme Morgan pleads for patience and politeness from England’s autograph hunters Self-confessed ‘golf tragic’ Dan Carter keen to boost participation in Ireland

One of the mothers who successfully sued a North Carolina charter school over its requirement that girls wear skirts says she always knew she'd prevail

SAN FRANCISCO--(BUSINESS WIRE)--Oct 10, 2023--

In a statement regarding his wife's health, Pete Sampras wrote that he's facing a challenge that has tested his strength and resilience

The Biden administration’s decision to remove a Chinese organization from a sanctions list as part of a deal