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TAMUNING, Guam--(BUSINESS WIRE)--Aug 7, 2023--

Nate Diaz has said he knows the ‘secret’ to Jake Paul’s success as a boxer, while warning the YouTube star: ‘I’m in on it, too.’ UFC icon Diaz, 38, will make his professional boxing debut on Saturday, facing Paul in Dallas, Texas. The bout will mark Diaz’s first fight since leaving the UFC in September, when he submitted Tony Ferguson. Meanwhile, 26-year-old Paul last fought in February, suffering his first loss as he was beaten on points by Tommy Fury. Prior to that result, American Paul was unbeaten with wins over ex-UFC champions Anderson Silva and Tyron Woodley, as well as mixed martial arts star Ben Askren. Paul knocked out Askren, beat Woodley on points then via knockout in a rematch, before defeating Silva via decision. Addressing his compatriot’s boxing career ahead of their fight this weekend, Diaz said on Wednesday (2 August): “The thing about him is, he knows that MMA fighters can’t box and they’re in over their heads trying to box, because he went in there and worked a bunch over in training and in fights. “MMA fighters don’t know this, but the only thing about that is: I’m in on the same secret, and I’ve been in on that since I was 15. I’m not your average wrestler, MMA fighter. “I didn’t wrestle. When these guys he fought were in the wrestling room at five, six, seven, 10, 15 years old, I was boxing the whole neighbourhood, boxing every pro I could find. I was boxing the highest level I could find, my whole career.” As a mixed martial artist, Diaz is best known for his jiu-jitsu skills, although his volume striking and cardio also characterised his UFC run. In contrast, Woodley and Askren were predominantly wrestlers, although Silva is seen by many as the greatest striker in MMA history. Click here to subscribe to The Independent’s Sport YouTube channel for all the latest sports videos. Read More Jake Paul vs Nate Diaz live stream: How to watch fight online and on TV this weekend The hidden side of Jake Paul Amanda Serrano announces surprise return to MMA with PFL

WASHINGTON The U.S. Senate will begin consideration of a package including aid for Israel and Ukraine as soon

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Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Many a story has been told of a tattoo that ended in regret, notably centering on drunken dares or unfortunate reminders of relationships gone sour. But one social media star was left “lost for words” – and in floods of tears – after her “dream” design suffered an unfortunate (or perhaps intentional) typo. Tia Kabir, 19, from Australia, told her 92,000 TikTok followers that she’d travelled all the way to Bali to get inked, saying: “I’ve been dreaming to get this tattoo because I just don’t get tattoos all the time, I get one every few months.” Then, pointing at the design on her arm, she explained: “It’s supposed to say ‘Angel Energy’.” Sign up for our free Indy100 weekly newsletter But instead, as we can all see, it says “Energy Angel”. Her lament racked up more than four million views and 127,000 likes in just two days, as fellow TikTokers shared their condolences and other thoughts on the mishap. @tiakabirr Im lost for words #tattoo #fypシ #fail #foryou “Sending you all my Engery you Angel,” wrote one wellwisher. “Honestly it’s not that bad it can still be meaningful and looks well done,” reassured another. However, hundreds of others were less understanding. “I mean angel energy isn’t any better,” wrote one unsympathetic viewer. “You know you can look at the stencil before they start tattooing right?” another pointed out. Indeed, countless commentators remarked that Tia only had herself to blame. “You didn't confirm the stencil with them before they started tattooing? That's on you girl.” “Moral of the story,” said another critic, “Get tattoos in your own country.” In an interview with news.com.au, after her video became a viral sensation, the teenager defended her alleged naivety at the time. She insisted that she’d provided the tattoo artist with a piece of paper that read “Angel Energy”, but it came up too big on her arm to be used for the stencil. “So after they made it a tiny bit smaller, somehow it flipped around saying ‘Energy Angel’ but I didn’t notice,” she said. “It was only after it was done that I checked it. It put me into shock.” In a separate interview with LADBible, she explained that she burst into tears when she saw the “monstrosity” on her arm, and her reaction caught the attention of fellow customers. "Even the staff were laughing and talking in their local language which brought me to tears," she told the site. "After asking reception what could be done the best I was told is that it has a different meaning and that the English is the other way around." She claimed that she’d been told she was entitled to a refund but, when she returned the next day, staff refused to give her her money back. In a subsequent TikTok update, Tia said she’d been bowled over by the attention her video had received and admitted that she found it all “kind of exciting”. She then reassured her fans that, “thank God”, her tattoo had been fixed and now reads: “Energy of an Angel”. She ended her clip by thanking her supporters for all the “unconditional love” they’d shown her, before addressing her “haters” only to stick her tongue out at them. Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.