Two shootings three decades apart at the University of North Carolina show how much has changed

UK singer and songwriter Rita Ora is no new to 'The Masked Singer'

More than 5,300 people died after dam bursts brought devastating floods to the eastern city of Derna.

‘Today’ host Hoda Kotb was nowhere to be found on Wednesday’s episode following her cryptic posts she shared on her Instagram

Covering a meeting between Russian President Vladimir Putin and North Korean leader Kim Jong Un might best be described as a caption contest: The two held what the Kremlin called "very substantive" discussions on Wednesday, but beyond a few photo opportunities, we still have very little idea what went on behind closed doors.

While the nation has been transfixed by the two-week manhunt for escaped prisoner Danelo Souza Cavalcante, another fugitive drama has been playing out in the nation's capital with comparatively minimal attention

Lawyers for impeached Attorney General of Texas Ken Paxton are set to start their defense Thursday in the trial to determine whether the Republican should be removed from office

Efforts by the Biden administration to limit tailpipe pollution from automobiles — a major source of planet-warming emissions — face a crucial test as legal challenges brought by Republican-led states head to a federal appeals court

SAN DIEGO--(BUSINESS WIRE)--Sep 14, 2023--

Russian President Vladimir Putin accepted an invitation from Kim Jong Un to visit North Korea after the two

The son of ousted Myanmar leader Aung Sang Suu Kyi says he has always avoided talking to the media, but this time is different

A treatment for acute migraines has been approved for NHS use for the first time, with experts saying the move could be a “step-change” for thousands of people who suffer from the condition. The National Institute for Health and Care Excellence (Nice) said its final draft guidance on Rimegepant “addresses the high unmet need for treatment options for acute migraine”. Rimegepant, also known as Vydura and made by Pfizer, will be available to adults who have tried at least two triptans – medication usually given to tackle headaches or migraines – but found they did not work well enough. It can also be administered to those who are not able to take triptans or have an intolerance, or patients who have tried nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol. Helen Knight, director of medicines evaluation at Nice, said: “Migraine is a condition described in comments to Nice from carers and people with migraine as an invisible disability that affects all aspects of life including work, education, finances, mental health, social activities and family. “Today’s final draft guidance addresses the high unmet need for treatment options for acute migraine, once again demonstrating our ability to ensure clinically and cost-effective medicines are available to those who need them as quickly as possible.” Rimegepant is taken as a wafer, which dissolves under the tongue and works by stopping the release of a protein around the brain called calcitonin gene-related peptide. In July, the medicine was recommended as an option for preventing episodic migraines in adults who have at least four and fewer than 15 attacks per month if “at least” three other treatments have not worked. This is the first and only Nice-recommended medicine that can help alleviate the misery of acute migraines, and may be considered a step-change in treatment Helen Knight, Nice Under the latest guidance, it will also be used to relieve symptoms of a migraine, which can include pain, nausea and sensitivity to light, but also painless symptoms such as temporary visual disturbances known as “aura”, which Nice said “is not well managed with existing treatments”. The recommendation is expected to benefit about 13,000 people. Ms Knight added: “This is the first and only Nice-recommended medicine that can help alleviate the misery of acute migraines, and may be considered a step-change in treatment.” Migraine is an incredibly misunderstood condition that can have a significant impact on all areas of life, including ability to work, maintain relationships and mental health Robert Music, The Migraine Trust Robert Music, chief executive of The Migraine Trust, said the Nice guidance “provides people with migraine valuable options to help reduce the pain and length of a migraine attack”. “It brings new hope,” he added. “It will especially benefit those who have not found a treatment that works, those who get debilitating side effects – including medicine overuse headache – from them, and those with cardiovascular disease who cannot take existing treatments. “Migraine is an incredibly misunderstood condition that can have a significant impact on all areas of life, including ability to work, maintain relationships and mental health.” Read More NHS winter resilience fund announced by Government NHS reliance on paper notes ‘stopping trusts from realising full potential’ Recession fears as UK economy shrinks by more than expected in shock decline Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live