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Almost 300 babies are born in the UK with sickle cells every year, according to the Sickle Cell Society, and the effects of sickle cell disease are believed to impact thousands. Yet, many people may not even know what sickle cells are or what living with the condition means. What is sickle cell disease? In most people, red blood cells are disc shaped and move easily through the blood vessels. But if you have sickle cell disease, your red blood cells are shaped like a sickle (similar to a crescent moon). This stops them moving with ease through the body and blood flow becomes restricted. Sickle cell disease isn’t actually one specific disease – it refers to a group of conditions affecting people with sickle cells, which range in severity.The conditions are inherited and predominantly affect people from African and Caribbean family backgrounds. What are the symptoms of sickle cell disease? Symptoms begin early in childhood and can sometimes be debilitating. How each individual is affected may vary, but the main symptoms are anaemia, an increased risk of infections, and pain. This includes extremely painful episodes called ‘sickle cell crisis’, which happens when blood flow to certain parts of the body become blocked. According to the NHS, these episodes can last for days and require hospitalisation. Other issues are associated with the condition too, including problems with the lungs, delayed growth in childhood, higher risk of stroke, leg ulcers and sight/vision problems.How is it diagnosed? Sickle cell disease is usually picked up during pregnancy or shortly after birth, although a blood test can be given at any time to see if someone has the condition or carries sickle cell genes. In parts of the country, pregnant people will be offered a test to see what the chances are of their child having sickle cells. Infants can be checked for the cells through a heel prick test.How do you treat it? Treating sickle cell disease is usually a lifelong process to help people with pain and to stay as healthy as possible. Treatment takes place in specific sickle cell centres and those living with it are encouraged to take care of their health, no matter the severity of their symptoms. Managing pain is a huge part of treating sickle cell disease. Staying hydrated can be helpful, as well as avoiding sudden temperature changes, like getting into a cold shower or diving into water. According to the NHS, Hydroxycarbamide (hydroxyurea) may be recommended, which is taken as a pill once a day. This can lower the quantity of other blood cells and requires careful monitoring, however. Some people may also be able to have a medicine called crizanlizumab, either on its own or alongside hydroxycarbamide, usually injected into a vein every four weeks. To prevent infections, many people with sickle cell disease will take daily antibiotics. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live TikTok has gone wild for adult gymnastics – here’s what you should know Man explains why he swapped veganism for raw meat diet: ‘I feel great’ Rugby star Ugo Monye: Boarding school shaped my career and my personality

It's 26 years to the day since Diana, Princess of Wales, died following a car crash in Paris, France along with her partner Dodi Fayed and driver Henri Paul. Diana was arguably the most famous woman in the world at the time and the level of devotion to her by the public will possibly never be seen again for a member of the Royal family. The outpouring of grief in the weeks that followed her death was unlike anything the UK has ever seen and the response was similar elsewhere around the world. One particular clip which sums this up is a now-viral video filmed by Alan Light who was playing cards with his friends in Iowa City, Iowa on that fateful night in 1997. Light was testing out his new camcorder and while everyone is in a good mood at the start of the video one of the friends does mention that Diana had been gravely injured because of the crash. They continue to play cards with CNN's coverage playing in the background. However, the atmosphere soon changes a few minutes into the video when CNN announces that Diana has passed away causing them to be utterly shellshocked by the news. Friends shocked to learn Princess Diana is dead (Historic 1997 video) www.youtube.com The rest of the near 7-minute video plays out with the friends quietly watching the coverage of the event on CNN. The video has been viewed more than 10 million times on YouTube alone and is considered to be one of the first ever reaction videos, even though the men involved at the time weren't aware of that. Since sharing the video in 2021, Light has been inundated with questions about why he was filming at that exact moment. He recently answered those queries in the comments section of the video. He wrote: "I recorded this home video in 1997 the night Diana died and it sat in a box for many years. Why was I recording? I was trying out a new camcorder by recording friends playing the card game UNO. When my mom called me to say that Diana was in a car crash I turned on the TV, on silent, and we kept playing the game while monitoring the text on the bottom of the TV screen. "When the screen text changed to "Diana dead" the true reality of the situation hit like a ton of bricks and we stopped playing UNO of course, and rushed over to the TV. This was recorded in America, in the state of Iowa. All of the guys in the video are still alive today (as of today, June 6, 2022). "The guy who screams when he learns Diana has died is my friend Ken who still lives in Cedar Rapids, Iowa. It is his genuine reaction to the news of Diana's death. Some people call it a "Wilhelm scream." (Apparently that's a movie term). The guy who stifles a smile after Ken's scream is Scott (his brief smile was a reaction to Ken's loud silly scream, NOT to Diana's death). "When CNN announced that Diana had died I didn't turn the camera back to the TV because my instinct was that it would be more interesting to capture my friends' reactions. Some people call this video the first of what are now called "reaction" videos, a term that didn't exist in 1997 (and neither did YouTube, which began in 2005)." Sign up to our new free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

The Champions League is back and the draw will take place later today to decide the 2023/24 group stage. Four English clubs are in the draw: the reigning champions Manchester City, along with Arsenal, Manchester United and Newcastle United. For the final time before the competition takes on a new format next season, 32 teams will be split into eight groups of four. Each group will contain one team from each of the four seeded pots, and clubs from the same national league will not be drawn together in the same group. Pot 1 will consist of the Champions League winners, the Europa League winners and six domestic champions of the highest ranked leagues. The remaining pots will be decided by Uefa’s club coefficient rankings. The final will take place at London’s Wembley Stadium on 1 June 2024. When is the Champions League draw? The draw for the group stage will take place in Monaco on Thursday 31 August, at 5pm BST. How to watch on TV and online The draw will be televised live in the UK on TNT Sports (formerly BT Sport) for subscribing customers, and will be available on the TNT Sports app. You can also live stream the draw for free on the Uefa website and YouTube channel. Which clubs have qualified? There are 32 clubs qualified for the Champions League group stage: England: Arsenal, Manchester City, Manchester United, Newcastle United Spain: Atletico Madrid, Barcelona, Real Madrid, Real Sociedad, Sevilla Germany: Bayern Munich, Borussia Dortmund, Leipzig, Union Berlin Italy: Inter Milan, Lazio, AC Milan, Napoli France: Lens, Paris Saint-Germain Portugal: Benfica, Porto, Braga Netherlands: Feyenoord, PSV Austria: Salzburg Scotland: Celtic Serbia: Red Star Belgrade Ukraine: Shakhtar Donetsk Belgium: Antwerp Switzerland: Young Boys Turkey: Galatasaray Ukraine: Shakhtar Donetsk What are the Champions League group stage dates? Matchday 1: 19/20 September 2023 Matchday 2: 3/4 October 2023 Matchday 3: 24/25 October 2023 Matchday 4: 7/8 November 2023 Matchday 5: 28/29 November 2023 Matchday 6: 12/13 December 2023 Read More When is the Champions League group stage draw? On This Day in 2016: David Luiz returns to Chelsea Rangers fail to qualify for Champions League after thrashing by PSV Eindhoven Is PSV vs Rangers on TV? Kick-off time, channel and how to watch On this day in 2015: Manchester City sign Kevin De Bruyne for club-record fee Chelsea’s Academy stars can rise to Carabao Cup challenge – Mauricio Pochettino

The train driver was treated by an ambulance at the scene for shock, but was physically unharmed.

What the papers say With the transfer deadline looming, Premier League sides are making their final moves as the clock ticks down to September 1. According to the Daily Mail, one of the big moves could see a star name leave the Premier League, with Saudi Arabian side Al-Ittihad gearing up for a £118million bid for Egyptian forward Mohamed Salah, 31. The Daily Star reports that Liverpool boss Jurgen Klopp would be “furious” if the move went ahead. The Daily Mirror reports Manchester United are keen to nab a midfielder before the transfer window closes, with Sofyan Amrabat, 27, their prime target. The Daily Mail reports Fiorentina have turned down a £1.7million loan deal but would consider a deal with an obligation to buy. One player who could be on his way out of Old Trafford is English defender Teden Mengi. Luton are close to signing him, according to the Daily Mail. Tottenham’s move for Wales forward Brennan Johnson, 22, from Nottingham Forest has stalled, according to The Independent. Crystal Palace’s Eberechi Eze, 25, has emerged as a new target. Social media round-up Players to watch Callum Hudson-Odoi: Nottingham Forest are close to a deal for the England winger, 22, from Chelsea, according to the Guardian. James McAtee: Manchester City’s England Under-21s midfielder could return for a second loan spell at Sheffield United, who are leading the chase for him, according to Football Insider. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live

UBS Group AG posted the biggest-ever quarterly profit for a bank in the second quarter as a result

A small tornado flipped a car in South Carolina during Hurricane Idalia.

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David Luiz rejoined Chelsea from Paris St Germain in a £32million deal on this day in 2016. The Brazil international returned to familiar territory as then Blues boss Antonio Conte shuffled his pack with full-back Marcos Alonso also arriving from Fiorentina as midfielder Juan Cuadrado joined Juventus on loan. Luiz, then 23, had initially joined Chelsea from Portuguese side Benfica in a deal worth up to £25million in January 2011. He had arrived at Stamford Bridge on the same day as striker Fernando Torres, who cost the reigning champions £50million – a record transfer fee between British clubs – when they lured him away from Liverpool. The defender made 143 appearances in his first spell and won the Champions League, Europa League and the FA Cup before Paris St Germain paid £50million for his services in June 2014 with then Chelsea manager Jose Mourinho preferring to use Gary Cahill and John Terry at the heart of his rearguard. Luiz’s time in France proved hugely successful as PSG dominated on the domestic front, but after two seasons at the Parc des Princes, he could not resist the opportunity to renew his acquaintance with English football. Speaking as his return to the Blues was confirmed, he told the club’s official website: “I’m delighted to return to Chelsea. We had a fantastic story during my first time at the club and I want to help the team and Antonio Conte achieve a lot of success. “I always had a wonderful relationship with the fans and I am looking forward to wearing the blue shirt at Stamford Bridge once again.” Over the length of his three-year contract, Luiz added a league title, an FA Cup and another Europa League trophy to his tally before making a shock – and for some, controversial – £8million move to derby rivals Arsenal in August 2019 after indicating his desire to leave. Luiz spent two seasons at the Emirates Stadium and, now 36, is currently playing his club football with Flamengo in Brazil’s Serie A. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live