List of All Articles with Tag 'al'

By Elvira Pollina and Supantha Mukherjee MILAN/STOCKHOLM Italy's data protection authority Garante plans to review other artificial intelligence

The menopause treatment fezolinetant has been predicted as a “gamechanger” by experts for thousands of women who suffer from hot flushes. The drug, which is the first non-hormonal menopause treatment, was recently approved by America’s FDA. Experts are predicting it could be transformative for women for whom hormone replacement drugs (HRT) are not suitable. The drug was licensed in the US on 12 May and could be approved for use in the UK by the end of the year. According to a British Menopause Society survey, 79 per cent of women aged 45 to 65 experienced hot flushes as a result of their menopause transition, while 10 to 20 per cent describe the hot flushes as “near intolerable”. Here’s everything you need to know about fezolinetant: What is it used to treat? It works to target the menopause symptom of hot flushes. The drug that has been approved by the FDA is made by pharmaceutical company Astella, which advises patients to take one 45-milligram of its VEZOAH (fezolinetant) pill orally, once a day. A large clinical trial of fezolinetant published earlier this year revealed that, after 12 weeks of use, it reduced the frequency of hot flushes by about 60 per cent in women with moderate or severe symptoms, in comparison to a 45 per cent reduction in those who received a placebo. Women involved in the trial also said the drug reduced the severity of hot flushes and improved the quality of their sleep. How does it work? It works by blocking a brain protein called neurokinin-3, which plays a unique role in regulating body temperature in menopausal women. Respondents of the trial have said that the effects of the drug was experienced after taking the first tablet. By comparison, HRT, taken to alleviate menopausal symptoms, replaces the oestrogen that you lose during the menopause transition, either alone or in combination with a progestogen What are the side effects? According to the FDA, the most common side effects are abdominal pain, diarrhoea, insomnia, back pain, hot flush and elevated hepatic transaminases. What have experts said about it? “This is going to be a completely blockbuster drug,” said Prof Waljit Dhillo, an endocrinologist at Imperial College London who led a trial for the drug in 2017 toldThe Guardian. “It’s like a switch. Within a day or two the flushes go away. It’s unbelievable how well these drugs work. It’s going to be completely game changing for a lot of women.” Read More Adenomyosis: 5 things you need to know about the ‘evil twin sister’ of endometriosis ‘Suddenly, I saw Dad again’: The radical technology helping those living with dementia Naga Munchetty reveals womb condition adenomyosis: ‘I live every day on painkillers’

Chevron Corp. said it will buy driller PDC Energy Inc. in a $6.3 billion all-stock deal, allowing Chevron

Manchester City are celebrating another Premier League title but their season is far from done as they also target FA Cup and Champions League success. Here, the PA news agency looks at their plans for their coming weeks. How will Pep Guardiola approach their final two Premier League games? With the Premier League title race over, City can afford to ease up for their two remaining league games – away to Brighton and Brentford – before switching attention to their two finals. The line-up for Sunday’s dead rubber against Chelsea, when manager Guardiola named most of his big guns on the bench, showed he intends to lighten his star names’ load. Yet there is also a need to keep players sharp and prevent rustiness. There may be a clue to his thinking in the line-ups for the two Premier League games immediately prior to the Champions League semi-final first leg against Real Madrid. In those matches, against West Ham and Leeds, Guardiola gave all his starting XI against Madrid game time but only one – Erling Haaland – started both. We could see a similar approach with half the first-choice side starting the first game, and the other half the second. Are there any injury concerns? City have had a good season in terms of squad fitness with relatively few injuries. Defender Nathan Ake is currently their only sidelined player with a hamstring problem. The Netherlands international has enjoyed a fine campaign but time is short. He may need to get some action against either Brighton or Brentford to have a chance of starting against Manchester United at Wembley or Inter Milan in Istanbul. What will the approach to the finals from City be? Obviously it is hard to make predictions but it is notable that Guardiola named the same side for City’s three biggest games of recent weeks – the crunch Premier League clash with Arsenal and both legs against Real Madrid. With performance levels in those games outstanding, it would appear he has found his ideal big-match XI. There could be some room for deviation in the FA Cup – for instance Stefan Ortega has been the regular domestic cup starting keeper and Riyad Mahrez’s semi-final hat-trick may earn him another outing – but the side for Istanbul would seem at least pencilled in. Can Manchester United stop City winning the treble? United’s fans may view their own team as the best hope of stopping City emulating their famous 1999 treble. City will be firm favourites to win both finals but Manchester derbies can be unpredictable. City thrashed their neighbours 6-3 in October but United got revenge when they met again at Old Trafford in January. There was some controversy over United’s equaliser in the 2-1 win but the Red Devils proved they can compete with City on a given day. City, of course, have hit their stride since and United’s mid-season charge has slowed, but Erik ten Hag’s team can shine on a one-off occasion. Do Inter pose a threat to City? After thrashing Madrid in the previous round, City seem destined to finally claim the Champions League prize this term. It is difficult to see Inter, currently the fourth best team in Serie A, containing them. Yet the Italians are defensively strong and do pose a threat through the likes of Romelu Lukaku, Lautaro Martinez and former City striker Edin Dzeko, so they may have a puncher’s chance. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live I have lived an absolute dream – Mark Cavendish sets date for cycling retirement Mark Cavendish: The journey from ‘fat banker’ to cycling’s greatest sprinter Mark Cavendish to retire from cycling at the end of the year

Nottingham Forest are keen to secure loan stars Keylor Navas and Renan Lodi beyond the 2022/23 season.

The boss of a London FX firm was found guilty of seven counts of fraud for his role

A North Carolina man is planning to use his $100,000 lottery prize to help build classrooms for children in his hometown in Mali.

Earlier this year, a new beer appeared on the menu at Fox City Brewing Company in Forsyth, Georgia.

Real Madrid say racism directed at Vinicius Junior constitutes a ‘hate crime’ and have filed a complaint with the Spanish State Attorney General’s Office. Brazil forward Vinicius was the subject of an alleged racist attack during Real’s 1-0 LaLiga defeat at Valencia on Sunday. The game was paused after the break as Vinicius pointed out to the referee those who were allegedly abusing him in the stands at the Mestalla – and the 22-year-old later took to social media to say racism is ‘normal’ in LaLiga. “Real Madrid CF shows its strongest revulsion and condemns the events that took place yesterday against our player Vinicius Junior,” the club said in a strongly-worded statement on Monday. “These facts constitute a direct attack on the coexistence model of our social and democratic state of law. “Real Madrid considers that such attacks also constitute a hate crime, for which reason it has filed the corresponding complaint with the state attorney general’s office, specifically with the prosecutor’s office against hate crimes and discrimination, so that the facts can be investigated and clear responsibilities. “Article 124 of the Spanish constitution establishes the functions of the public prosecutor’s office to promote the action of justice in defence of legality and the rights of citizens and the public interest. “For this reason, and given the seriousness of the events that occurred, Real Madrid has turned to the sate attorney general’s office, without prejudice to its appearance as a private prosecution in the proceedings that are being initiated.” In a statement on Instagram, Vinicius – who was sent off for violent conduct in added time of Real’s defeat following an altercation with striker Hugo Duro – said: “It wasn’t the first time, not the second and not the third. Racism is normal in LaLiga. “The competition thinks it’s normal, so does the Federation and the opponents encourage it. I am so sorry. “The championship that once belonged to Ronaldinho, Ronaldo, Cristiano (Ronaldo) and (Lionel) Messi, today belongs to the racists. “A beautiful nation, which welcomed me and I love, but which accepted to export the image to the world from a racist country. “Sorry for the Spaniards who do not agree, but today, in Brazil, Spain is known as a country of racists. “And unfortunately with everything that happens on a weekly basis, I have no way to defend. I agree. But I’m strong and will go to the end against the racists. Even though it’s far from here.” LaLiga president Javier Tebas responded to Vinicius’ post on Sunday by accusing the forward for “criticising and insulting” the league. In another tweet on Monday, Tebas said: “Neither Spain nor @LaLiga are racist. It is very unfair to say this. “How @LaLiga we denounce and fight racism with all rigidity within our competences. This season there were 9 cases of racist insults (8 of them for insults against @vinijr) “We always identify the violators and take the complaint to the legislating bodies. It doesn’t matter that they are few, they are relentless. “We cannot allow the image of a competition that is about the symbol of peoples union to be tarnished, where more than 200 players are of black origin in 42 clubs that receive in each round the respect and affection of the fans, being the racism an extremely specific case (9 complaints) that we are going to eliminate.” Valencia released a statement on their club website condemning what happened and confirming they will investigate what happened. Former England and Manchester United defender Rio Ferdinand took to Instagram in support of Vinicius and questioned player protection. “Bro you need protecting….who is protecting Vinicius Junior in Spain??” Ferdinand posted. “He receives a red card after being choked and receiving racial abuse during the game… wtf. “How many times do we need to see this young man subjected to this s**t?? I see pain, I see disgust, I see him needing help… and the authorities don’t do s**t to help him. “People need to stand together and demand more from the authorities that run our game. “No one deserves this, yet you are allowing it. There needs to be a unified approach to this otherwise it will be swept under the carpet AGAIN.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Glamorgan aiming to make cricket more diverse in Wales John Stones wants Man City to ‘make some more history’ as they chase treble Norrie up and down as Murray and Raducanu sit out – British tennis picture

Ghana’s central bank paused its steepest phase of monetary tightening, after clinching a $3 billion lifeboat from the

Provides an overview of Moldova, including key events and facts about this east European country.

An overview of the media in Transnistria, including links to broadcasters and newspapers.