Walgreens CEO exits less than 3 years after taking over drug store chain
The CEO of Walgreens Boots is stepping down after less than three years at the helm of the drug store chain
1970-01-01 08:00
Ford expects to take about $270 million charge related to SUV, van recall
Ford Motor said on Friday it expects to take about $270 million charge for a previously announced recall
1970-01-01 08:00
How 'unrecognizable' Angus T Jones turned his back on 'filth Two-and-a-Half Men' and found God
Angus T Jones acted for 10 long years on 'Two and a Half Men'
1970-01-01 08:00
Spanish men's national team manager Luis de la Fuente apologizes for applauding Luis Rubiales' defiant speech
Luis de la Fuente, the manager of the Spanish men's national team, has apologized for visibly applauding the speech of beleaguered soccer chief Luis Rubiales at an assembly last Friday.
1970-01-01 08:00
Scientists have discovered a new 'Antarctica' accent
Antarctica might be the only continent on Earth with no natural human habitation, but it’s emerged that an “Antarctica accent” is very much a thing. Despite having no locals, thousands of scientists have made up an ever-changing population in research stations over the years. The continent is so isolated and the level of interaction between researchers is so intense, that a common accent is beginning to emerge there despite people coming from different parts of the world. At its busiest points in the year during the summer, Antarctica is home to around 5,000 people. Only around 1,000 people live there during the winter months. The idea of accents changing due to human interaction on Antarctica is no different to the phenomenon seen throughout history at a glacial pace. However, given the very specific sample size, it’s an opportunity for scientists to study it at a much quicker rate and on a much smaller scale. Experts at the Ludwig Maximilian University of Munich published a study in 2019 which focused on the change in accents observed in 11 people who took part in the British Antarctic Survey. @human.1011 There’s an Antarctic Accent! #language #linguistics #english #antarctica Of the 11 who were studied, eight came from England, one from the US, one from Germany and one from Iceland. Their voices were recorded every six weeks, and the team found that over time they developed longer vowel sounds. There was a physical change too, with participants pronouncing the “ou” sound in the front of their mouths rather than the back of their throats. Speaking to IFL Science, Jonathan Harrington, study author and Professor of Phonetics and Speech Processing at the Ludwig-Maximilians University of Munich said: "The Antarctic accent is not really perceptible as such – it would take much longer for it to become so – but it is acoustically measurable. "It's mostly an amalgamation of some aspects of the spoken accents of the winterers before they went to Antarctica, together with an innovation. It's far more embryonic [than conventional English accents] given that it had only a short time to develop and also, of course, because it's only distributed across a small group of speakers.” Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.
1970-01-01 08:00
Dollar drops as unemployment rate rises, wage growth misses expectations
By Karen Brettell NEW YORK The dollar fell against the euro and Japanese yen on Friday after the
1970-01-01 08:00
Robinhood to buy back Bankman-Fried's stake for $605.7 million from US govt
(Reuters) -Robinhood said on Friday it had entered into a share repurchase agreement with the United States Marshal Service(USMS) for
1970-01-01 08:00
Chris Eubank Jr, Liam Smith and the revelation that changed everything
The last fight between Liam Smith and Chris Eubank Jr finished in chaos and confusion back in January. It was perhaps the only way the fight and the week could finish; there was a capacity crowd of just under 20,000 in Manchester and a ring packed with screaming people. On Saturday they do it all again and this time, it is serious. Manchester is once again the venue. Eubank Jr was dropped twice in the fourth but was up on unsteady legs, insisting he could continue, when it was called off after 69 unforgettable seconds. Eubank Jr was actually steered back to his own corner by Smith’s trainer, Joe McNally. It was an act of compassion surrounded by a night of hate and violence. The fight was stopped at the right time. Eubank Jr has since sacked his trainer from the night, Roy Jones Jr, and hired Brian BoMac McIntyre, who works with Terence Crawford. BoMac runs a strict gym and that is, probably, what Eubank Jr after 13 years as a professional and 35 fights desperately needs. It is never too late to learn in the boxing business. Smith returned to the Rotunda gym, arguably one of the most successful amateur boxing clubs in the world, and continued to prepare under the guidance of McNally. Smith and his party insist there will be more of the same when the bell sounds, and Eubank and his new gang are confident that they can change the outcome; both have enough to lose and an awful lot to gain from the fight. Smith has nothing to prove, Eubank Jr is under intense pressure. This fight has nothing to do with any parts of their colourful fighting history; this is just about repeat or revenge. The last time, the build-up was ugly and personal and this time it is just strictly business. Smith knows he can knock out Eubank Jr and Eubank Jr knows he can be knocked out. It was, trust me, a revelation to both boxers the way their first fight ended. Eubank Jr has conveniently claimed that he is a different man under BoMac’s glare, a smarter and better prepared fighter. He will need to be because, in the first fight, Smith was in control and looked in control. Sure, there was nothing in the fight up until the point where Smith trapped Eubank Jr in a corner and let his hands go. Eubank Jr slumped to the canvas, regained his feet, was dropped again and then got up one more time and was ready, so he claimed, to continue. He was not, it had to be stopped and that is where Saturday’s fight starts. The bad blood remains, the bragging rights are clear and the motive for revenge could not be any higher. At a time of pandering and preening YouTube boxers, crossover fights that only make sense at the bank, this second instalment is genuinely an old-school fight. There is no belt for family pride and that is a pity because that is the backdrop to this fight. Smith and his fighting brothers, Eubank Jr and his fighting father, uncles and cousins. Smith is confident that he can do it all again and Eubank Jr with the influence of BoMac is equally convinced that the result will be different. They can each look you in the eye and they would pass any test of truth – this is personal and that makes the most memorable fights. Smith at his best can do it all again, but Eubank Jr is fighting for his very survival. This is boxing at the very extreme. Watch Smith vs Eubank Jr 2 on Sky Sports Box Office on Saturday 2 September, live from the AO Arena in Manchester Read More Chris Eubank Jr on Liam Smith, adrenalin, and how to be ‘box office’ Eubank vs Smith 2 live stream: How to watch fight online and on TV this weekend Liam Smith: ‘Chris Eubank Jr is a nightmare – not for me, for other people’ Chris Eubank Jr and Liam Smith in heated debate over decisive factor in rematch Eddie Nketiah wins England call-up – Thursday’s sporting social Chris Eubank Jr on Liam Smith, adrenalin, and how to be ‘box office’
1970-01-01 08:00
Canadian economy unexpectedly contracts in Q2 ahead of rate decision
OTTAWA Canada's economy unexpectedly contracted in the second quarter, declining at an annualized rate of 0.2%, while real
1970-01-01 08:00
Country Garden: How bad are the Chinese property developer's debt problems?
By Xie Yu HONG KONG (Reuters) -China is grappling with a slowdown that has rattled global markets, with the spotlight
1970-01-01 08:00
Safe & Green Holdings Corp. Provides Detail on Expected Distribution Ratio for Spin-off
MIAMI--(BUSINESS WIRE)--Sep 1, 2023--
1970-01-01 08:00
Scientists believe they have found a cure for alcoholism
Alcohol addiction ruins millions of lives every year, but scientists may have found a cure for this terrible affliction. A new treatment for alcohol use disorder (AUD) has been trialled in monkeys with impressive results and, if these translate to human trials, the impact could be monumental. A team of neuroscientists and physiologists from across the US tested a new type of gene therapy to see if they could directly target the underlying brain circuitry associated with sustained heavy drinking. As they noted, in the journal Nature Medicine, people suffering from AUD commonly return to alcohol use even if they attempt to quit. This is largely to do with what’s known as mesolimbic dopamine (DA) signalling – meaning how the central nervous system circuit communicates the feelgood neurotransmitter dopamine. A protein called glial-derived neurotrophic factor (GDNF) is key to keeping these neurons in this reward circuitry functioning. However, experts have found that levels of GDNF are reduced in people with AUD during periods of alcohol abstinence, most notably in a region of the brain called the ventral tegmental area (VTA), as IFLScience notes. Therefore, the researchers decided to test whether using gene therapy to deliver more GDNF to the VTA could help reinforce this crucial dopaminergic signalling and prevent patients from suffering an alcoholic relapse. The team of scientists explained how alcohol consumption in non-addicts prompts the release of dopamine, creating a pleasurable buzz feeling, but chronic alcohol use causes the brain to adapt and stop releasing so much dopamine. “So when people are addicted to alcohol, they don’t really feel more pleasure in drinking,” Dr Kathleen Grant, a senior co-author of the study, said in a statement. “It seems that they’re drinking more because they feel a need to maintain an intoxicated state.” For their research, Dr Grant and her colleagues used eight rhesus macaque monkeys, who were exposed to increasing concentrations of alcohol over four 30-day “induction” periods. The monkeys then had free access to alcohol and water for 21 hours a day for six months, during which they developed heavy drinking behaviours. This was then followed by a 12-week abstinence phase, with the GDNF treatment performed four weeks in for half of the subjects. The gene therapy was delivered using a a viral vector containing a copy of the human GDNF gene injected directly into the primate’s VTA, according to IFLScience. And the results were truly jaw-dropping. “Drinking went down to almost zero,” Dr Grant said. “For months on end, these animals would choose to drink water and just avoid drinking alcohol altogether. They decreased their drinking to the point that it was so low we didn’t record a blood-alcohol level.” The most exciting aspect of their findings is the suggestion that gene therapy could offer a permanent solution for people with the most severe cases of AUD. This will be a welcome glimmer of hope to many, given that some 29.5 million people were diagnosed with AUD in the US alone in 2021, according to the National Institute on Alcohol Abuse and Alcoholism. Of these 29.5 million sufferers, almost a million (894,000) were aged between 12 and 17. It’ll likely be some time before we know for sure whether the gene therapy can be rolled out in humans, but it’s an important first step in tackling this devastating disorder. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.
1970-01-01 08:00
