List of All Articles with Tag 'e'

In the post shared on Sunday, Olivia Dunne can be seen hanging out with friends at Tiger Stadium in Baton Rouge

The market for environmental, social and corporate governance, or ESG, investing is fundamentally broken.

Using existing drugs to treat cervical cancer before standard treatment could lead to a 35% reduction in the risk of relapse or death, a new study suggests. Researchers from the UCL Cancer Institute and UCLH looked into whether a short course of induction chemotherapy (IC), where a drug is used to destroy as many cancer cells as possible, before chemoradiation (CRT), could help with this. Here’s everything you need to know about the findings… What is cervical cancer? According to the NHS website, cervical cancer is a type of cancer found anywhere near the cervix – the opening between the vagina and the womb (uterus), which is also known as the neck of the womb. Most cervical cancers grow very slowly and are caused by an infection from specific types of human papillomavirus (HPV) and mostly affect women under the age of 45. According to Jo’s Cervical Cancer Trust, symptoms include vaginal bleeding that is unusual to you, changes to vaginal discharge, discomfort during sex and pain in your lower back or pelvis. Changes to cells can be spotted by a cervical screening, and then treated before they turn into cancer. There are around 3,200 new cases every year in the UK, with the five-year survival rate being around 70%, according to Cancer Research UK. CRT has been the standard treatment for cervical cancer patients since 1999, but even though there have been overall significant developments in radiation therapy techniques, up to 30% of people experience their cancer coming back. What did the research involve? Over a 10-year period, 500 patients who had been diagnosed with cervical cancer – that was large enough to see without a microscope but hadn’t spread to other parts of the body – took part in the Interlace trial at hospitals in the UK, Mexico, India, Italy and Brazil. Researchers looked into whether a short course of IC before CRT could reduce rates of relapse and death. What results were found? After five years, researchers discovered that 80% of the people who received a combination of chemotherapy and radiotherapy were alive, whilst 73% had not seen their cancer return or spread. A major benefit, according to researchers, is that it can be incorporated into standard of care treatment relatively quickly, because cheap, accessible and already-approved ingredients such as carboplatin and paclitaxel are needed for IC. “Our trial shows that this short course of additional chemotherapy delivered immediately before the standard CRT can reduce the risk of the cancer returning or death by 35%,” said Dr Mary McCormack, lead investigator of the trial from UCL Cancer Institute and UCLH. “This is the biggest improvement in outcome in this disease in over 20 years. “I’m incredibly proud of all the patients who participated in the trial; their contribution has allowed us to gather the evidence needed to improve treatment of cervical cancer patients everywhere. “We couldn’t have done this without the generous support of Cancer Research UK.” Why is the research important? Dr Iain Foulkes, executive director of research and innovation at Cancer Research UK, said: “Timing is everything when you’re treating cancer. The simple act of adding induction chemotherapy to the start of chemoradiation treatment for cervical cancer has delivered remarkable results in this trial. “A growing body of evidence is showing the value of additional rounds of chemotherapy before other treatments like surgery and radiotherapy in several other cancers. “Not only can it reduce the chances of cancer coming back, it can be delivered quickly using drugs already available worldwide. “We’re excited for the improvements this trial could bring to cervical cancer treatment and hope short courses of induction chemotherapy will be rapidly adopted in the clinic.”

Khabib Nurmagomedov has clarified why he missed childhood friend and UFC protege Islam Makhachev’s stunning victory over Alexander Volkanovski. The former UFC champion, who finished his career with an unbeaten 29-0 record, said it was not unusual for him to not be in the corner in Abu Dhabi on Saturday night. Nurmagomedov became Makhachev’s coach following his retirement in 2020, but the ‘Eagle’ announced earlier this year that he had taken a step back from the UFC. Makhachev stunned Volkanovski with a first-round knockout at UFC 294, retaining the lightweight title in their rematch. In February, Makhachev outpointed Volkanovski – who holds the featherweight belt – in the latter’s native Australia, in a competitive clash that left many fans desiring a rematch. Nurmagomedov congratulated Makhachev on his victory before responding to fans who had questioned his absence from ringside. “If you guys ask me where have I been? Why wasn’t I in the corner, I already answered this question,” he posted on Instagram. “I don’t go to fights, I don’t go to the corner and I completely left everything related to MMA. I ask you to accept my decision the same way as my brothers, friends and sparring partners did. What our team achieved will forever be in the history of MMA.” Makhachev had already addressed the fact that Nurmagomedov would not be in his corner before UFC 294, telling reporters that he understood and supported his mentor’s decision. “Here is my explanation: We have a very big team,” Makhachev said. “What if Khabib is there for one of us? We’re all equal. “No matter if somebody’s a champion and the other guy is still on his way up, we all support each other. If he is there for my fight, he will need to be there for every single one from our team to not let anyone feel abandoned. “He has already said that he will not attend the fights and he will not corner anyone. And we all support him in this decision.” Midway through the first round of the main event, southpaw Makhachev skimmed his left shin off Volkanovski’s head, wobbling and dropping the featherweight king. Makhachev, 31, followed up with a fierce flurry of hammer fists to the grounded Aussie, whose brow split open amid the onslaught. Referee Marc Goddard stepped in, confirming an emphatic victory and title defence for Makhachev, the mentee and childhood friend of UFC lightweight great Khabib Nurmagomedov. The result extended Makhachev’s win streak to 13 fights, dating back to 2015, when he suffered the sole loss of his professional career. Meanwhile, Volkanovski was beaten for the third time as a pro, though he remains undefeated at his preferred weight of 145lbs. Read More Alexander Volkanovski’s bravest move yet? Talking about his mental health Conor McGregor reacts to ‘illegal’ strikes in Islam Makhachev win at UFC 294 Makhachev stuns Volkanovski with head-kick KO in first round at UFC 294 UFC 294 LIVE: Volkanovski vs Makhachev fight results after shock KO Islam Makhachev demands two words from Alexander Volkanovski ahead of UFC 294 Volkanovski vs Makhachev gamble shows the best and worst of the UFC

Previewing Real Madrid's Champions League group stage game against Braga on Tuesday night, including how to watch on TV, live stream, predicted lineups and score prediction.

Mexicans dressed as skeletons parade through the streets of the capital ahead of the Day of the Dead.

Verve Therapeutics Inc. surged in premarket trading after US drug regulators lifted their hold on the company’s application

Houston Rockets guard Victor Oladipo has suggested the romance has led to Kelce's improved on-field performance

Mark Barlet founded AbleGamers in 2004

Spanish police say they have confiscated 11 pieces of ancient gold jewelry that were taken out of Ukraine illegally in 2016

Chelsea head coach Mauricio Pochettino has joked that he was left with no choice but to start Enzo Fernandez and Moises Caicedo in Saturday's draw with Arsenal despite the pair being tired as he feared the owners would kill him otherwise.

Jonathan Epstein, a prominent cancer-detecting pathologist, is on administrative leave after facing bullying claims from other practitioners