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Researchers have revealed how muscle cells deteriorate with age, affecting their ability to regenerate and recover after an injury. The findings could help to shed light on why it takes people longer to recover from muscle damage as they age. A team at Nottingham Trent University analysed the genes inside muscle cells, and found the ‘development pathways’ – the different ways in which genes work together to regenerate muscle – become weakened in older cells. We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get Dr Livia Santos, Nottingham Trent University Lead researcher Dr Livia Santos, an expert in musculoskeletal biology in Nottingham Trent University’s School of Science and Technology, said: “This goes some way towards explaining why muscle injuries may take longer to recover as we get older.” She added: “We know that healthy muscle regenerates after we’ve had an injury but ageing impairs that regeneration potential and recovery gets harder the older we get. “What we’ve observed, in terms of what happens inside the cells, helps us to better understand why we don’t heal as well or as quickly in older age. “The pathways that control cell processes and development work differently in older cells and are downregulated, meaning regeneration is impacted the older we get. “If we can understand these pathways, however, we could potentially identify new therapies and interventions to mitigate the problem.” The researchers developed a new approach to examine muscle cells in the laboratory to enable them to observe the different mechanisms that drive muscle ageing. They studied muscle cells from donors, chemically injuring cells after they had been donated and isolated, then assessing how they heal and regenerate back to their pre-injury baseline levels. When they looked at cells from a 20-year-old and a 68-year-old donor, researchers found distinct differences in the development pathways of the younger and older cells. While younger muscle cells fully recovered from the injury, the team found that in older cells the genes expressed less of what they needed to, leaving the cells no longer able to perform in the way they should. According to the researchers, this contributes to reduced regeneration capacity leading to thinner, less robust ‘myotubes’ – a type of cell that can fully develop into a muscle fibre. Muscle regeneration is a complex and finely balanced biological process and is known to deteriorate with ageing, leading to the decline of musculoskeletal health and in some cases metabolic and genetic diseases. Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing Researcher Janelle Tarum Janelle Tarum, another researcher on the study, said: “We’ve been able to develop a new approach to assess muscle regeneration which involves a state-of-the-art technique called RNA-sequencing. “There’s a very clear reduced regeneration capacity and weakened recovery of aged cells and we have been able to further understand the factors underlying this impairment. “Our work enables us to examine muscle cell regeneration across the lifespan and this in turn could be key for future drug discovery for disease related to muscle ageing.” The study, which also involved Manchester Metropolitan University and Liverpool John Moores University, is published in the Journal of Tissue Engineering and Regenerative Medicine.

The pair shared the embrace after The 1975 were banned from Malaysia due to the country's anti-gay stance.

A massive global gathering of scouts in South Korea has been forced to vacate the campsite a week early because of an approaching typhoon, days after extreme heat sickened hundreds of teens and sparked complaints over how the event was being run.

China is facing a growing international backlash after one of its coast guard vessels used a water cannon against a Philippine boat in the South China Sea on Saturday, an incident analysts say escalates an already tense situation and could see the United States and its allies speed up plans for joint patrols in the waterway.

Over 120 million people in the Eastern US are at risk of severe thunderstorms Monday that can hit communities from Philadelphia to Atlanta with damaging wind gusts, large hail, heavy rain and a few tornadoes.

Days of heavy rain have caused severe flooding in China's leading grain-producing region in the northeast, killing 14 people and raising concerns about food security as floodwater inundated farmlands.

Inter Miami player ratings from their dramatic 4-4 (5-3) triumph over FC Dallas in the round of 16 in the Leagues Cup.

Bella Hadid has shared a candid post reflecting on her health journey as she has lived with Lyme disease since 2012. The 26-year-old supermodel shared a health update with her 59.3 million followers on Instagram on Sunday (6 August) and said she is “finally healthy” after more than a decade of struggling with her health. She shared a number of photographs taken during her treatments over the years, showing her receiving drips and injections, laying in hospital beds as nurses gave her medication, and health documents from her medical record. In her lengthy caption, Hadid wrote: “The little me that suffered would be so proud of grown me for not giving up on myself. Living in this state, worsening with time and work while trying to make myself, my family and the people who support me, proud, has taken a toll on me in ways I can’t really explain.” “To be that sad and sick with the most blessings/privilege opportunity/love around me was quite possibly the most confusing thing ever,” she reflected. She reassured fans that she was “OK and you do not have to worry”, and said that despite her struggles, she “wouldn’t change anything for the world”. “If I had to go through all of this again, to get here, to this exact moment I’m in right now, with all of you, finally healthy, I would do it all again. It made me who I am today,” Hadid continued. The model, who was named one of Time magazine’s 100 most influential people in the world this year, “promised” fans who were also struggling that things “will get better”. “Take a step away, stay strong, have faith in your path, walk your truth and the clouds will start to clear up,” she wrote. “I have so much gratitude for and perspective on life, this 100+ days of Lyme, chronic disease, [co-infection] treatment, almost 15 years of invisible suffering, was all worth it if I’m able to, God-willing, have a lifetime of spreading love from a full cup and being able to truly be myself, for the first time ever.” Hadid explained that she chose photos that were “the most positive” throughout her health journey in an attempt to illustrate how it has been “the most enlightening experience of my life filled with new friends, new visions and a new brain”. She thanked her mother, Yolanda Hadid, who was also diagnosed with Lyme disease in 2012 alongside her son and Hadid’s younger brother Anwar, for “keeping all of my medical records, sticking by me, never leaving my side, supporting, but most of all, believing me through all of this”. Hadid also thanked the brands and companies she has worked with, her agents for “protecting me”, and her medical team, adding: “I love you SO much!!!” She told fans that she would be “back when I’m ready”, adding: “I miss you all so much. I love you all so much.” Lyme disease is a bacterial infection that can be spread to humans by infected ticks and if usually diagnosed based on symptoms, which include fever, headache, fatigue or skin rash, or laboratory testing. Earlier this year, Hadid spoke about some of the symptoms she gets when her Lyme disease flares up. In a TikTok video, she said: “My skin changes colour, I break out randomly, I get (what feels like) lesions, lethargy, chronic anxiety, zero motivation or purpose, leaky gut, adrenals, depression.” She added that she “hates looking in the mirror or taking pictures” of herself because of how the disease impacts her appearance. “If I’m all dolled up, maybe I’ll try for the girls but, man, is it hard to do this as your profession while also feeling/looking sick like this,” she said. Read More Doing things alone isn’t ‘self-love’ – we don’t need to make everything empowering Jamie Foxx and Jennifer Aniston issue statements over ‘antisemitic’ Instagram post Will Smith says daughter Willow’s ‘mutiny’ changed his view on success Is it heat exhaustion or are you just tired? Will Smith says Willow ‘mutiny’ changed his view on family success Health expert Dr Michael Mosley shares two tips for avoiding osteoporosis

The average cost of Russian crude landing on Indian shores in June was the lowest since Moscow’s invasion

China’s health-care stocks slumped as sentiment took a hit after authorities widened an anti-graft crackdown on the sector.

The UK chief executive says he feels let down by organisers of the World Scout Jamboree in South Korea.

Saudi Arabia’s latest oil pricing for Asian customers is pointing to an uneven recovery, with higher-density crudes outperforming