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U.S. health regulators have approved a new nasal spray to reverse overdoses due to fentanyl and other powerful opioids

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Newcastle’s biggest win in two decades was a draw. After a 20-year absence from the Champions League, they are back, perhaps headed to Madrid or Munich or Milan next season. A point was all they needed against Leicester and a point was what they got. It was a stalemate to savour for Eddie Howe, a largely uneventful game to demonstrate stunning progress in 18 months. Bottom after his first game in charge, Newcastle will now rub shoulders with the European elite. Perhaps a draw means they may face Leicester again next season, though their fate remains more uncertain. They finished three places above Newcastle last year and are 15 below them now. The turnaround has been a triumph of smart recruitment, excellent coaching and, less palatably for many outside Tyneside, Newcastle’s Saudi owners. United have had an injection of funds but some £250 million has largely been spent remarkably well. But around half the starting line-up tends to consist of players Howe inherited and who were winless three months into last season. Some have developed beyond recognition. So has a team: Newcastle’s aim for the season was to qualify for continental competition. Even a Conference League spot would have been considered a success, but instead they have vaulted back into the Champions League. It is a terrific feat by Howe, whose last full season of management culminated in Bournemouth’s relegation to the Championship. It may also be welcomed by one of the world’s more oppressive regimes, with Newcastle 80 percent owned by the Saudi Public Investment Fund. Two of their powerbrokers, Jamie Reuben and Mehrdad Ghodoussi, were applauded as they found the net in a half-time shootout. The players found it altogether harder to apply the finishing touch as they struck the woodwork three times. Which, ultimately, made more of a difference to Leicester, whose fate is out of their hands but who still have some hope; beat West Ham and, if Everton do not win, they will survive. Their plight concentrated their minds but Newcastle succeeded where they twice narrowly failed under Brendan Rodgers. He had twin fifth-place finishes from seasons when Leicester occupied top-four spots for the majority of the time. Newcastle have seen the job through. Perhaps both the scoreline and the venue were fitting. Only Liverpool and Arsenal have won at St James’ Park this season and only four clubs have triumphed there in Howe’s reign. They owe their top-four finish to consistency, particularly for a spell either side of the World Cup. A 17-game unbeaten run was, at one stage, the longest undefeated spell in any of Europe’s top five leagues. Only Manchester City have lost fewer Premier League matches this season and Newcastle, who have won as many games as Liverpool, can see the merit of the draw in the table. They have shown a toughness others lacked, a reliability and a resolve that meant they could grind their way to a point. They had a host of clean sheets in the first half of the season; they have been rarer of late but Nick Pope’s fine injury-time save from Timothy Castagne prevented defeat and spared them an anxious final day at Chelsea. They have benefited from two inspired scoring bursts, from Miguel Almiron in autumn and Callum Wilson in recent weeks. Perhaps it rendered it more of a surprise that Wilson endured an off night. Leicester kept a first clean sheet in six months, but they required assistance from the upright and relied on Newcastle’s radars malfunctioning. They had two double reprieves just before half-time. Wilson almost scored his eighth goal in six games, hooking a shot against the post and heading an effort Wilfred Ndidi cleared off the line. Then Almiron struck the post with a half-volley before Alexander Isak blazed over. Most glaringly. Bruno Guimaraes headed against the post from a yard out after Wout Faes had inadvertently flicked on Kieran Trippier’s corner. Leicester were entitled to argue – as John Terry seemed to – that the Brazilian should have been dispatched to the dressing room long before then but he escaped with a yellow card for planting his studs into Boubakary Soumare’s knee; had VAR intervened the punishment may have been greater. But Leicester got what they came for. Dean Smith adopted a policy of safety in numbers to bolster his porous rearguard, bringing in Harry Souttar as an extra centre-back and playing 5-3-2. Most contentiously – and arguably unsuccessfully given the lack of the threat the impotent strike duo of Jamie Vardy and Kelechi Iheanacho possessed – he benched his two top scorers. James Maddison came on at half-time, Harvey Barnes for the final half-hour. Neither altered proceedings even if, after his side camped behind the ball for much of the match, Smith urged them on at the end. So Leicester need favours from elsewhere on the last day of the season. Newcastle need none. Champions League, here they come. Read More Newcastle vs Leicester player ratings Callum Wilson and Miguel Almiron miss the mark Eddie Howe won’t ‘relax on a beach’ if Newcastle qualify for Champions League Newcastle may have Saudi riches, but Eddie Howe’s team is built on bargains

Nick Pope ensured Newcastle booked their Champions League place with a game to spare as he denied Leicester a priceless victory in their bid for Premier League survival. The Magpies’ £10million summer signing kept out Timothy Castagne’s volley in the second minute of stoppage time with his first save of the game to secure a 0-0 draw on a night when the home side battered at the door but were unable to find a way through. Callum Wilson and Miguel Almiron were both denied by the woodwork, but a point was all their team needed to ensure their place among the continent’s big boys for the first time in 20 years. By contrast, Leicester, who are still two points adrift of safety, will head into their final-day clash with West Ham knowing their fate is not in their own hands. Eddie Howe’s men were lauded by a crowd of 52,152 on the final whistle, having secured Champions League football for just the third time in the club’s history and way ahead of the schedule drawn up by the club’s Saudi-backed owners when they took control in October 2021. In some senses it proved to be a frustrating 90 minutes – it might have been more so had key midfielder Bruno Guimaraes seen red rather than yellow for a poor early challenge of Boubakary Soumare – but it was ultimately the bigger picture which mattered. Howe was forced to make a last-minute change when, after he had taken part in the warm-up, midfielder Joelinton was unable to start and was replaced by Elliot Anderson. Any fears the reshuffle might unsettle his team proved unfounded as they took the game by the scruff of the neck amid a party atmosphere at St James’ Park, although Guimaraes was perhaps fortunate to escape with only a booking for his studs-up ninth-minute clash with Soumare. The Magpies dominated possession but in the early stages were unable to find a telling final ball. Almiron, who had made another high-octane start, fired over after cutting inside from the right and Anderson tested goalkeeper Daniel Iversen for the first time with a curling attempt. Alexander Isak was seeing plenty of the ball down the left but sliced a long-range effort well wide as the Magpies piled forward repeatedly without ever really being able to summon up the required precision to make the pressure tell. For their part, City attempted to hit Jamie Vardy and Kelechi Iheanacho long and early and, although they achieved a measure of success, they met with stubborn resistance from Fabian Schar and Sven Botman. Wilson twice went close to his 19th goal of the season four minutes before the break when he stabbed a shot against a post and then saw Wilfred Ndidi clear his follow-up header off the line, while Almiron was similarly denied by the woodwork before Isak steered the rebound wide seconds later. Wilson headed over from a Kieran Trippier corner in stoppage time after Iversen had misjudged the flight and the half ended goalless. James Maddison entered the fray at the break as a replacement for Iheanacho, but the traffic continued to head very much in the direction of his team’s goal, with Isak and Almiron menacing out wide, although the massed ranks of blue held impressively firm. Iversen had to turn a 59th-minute Isak snapshot over his crossbar and block Sean Longstaff’s 76th-minute drive with a foot, but it was the Foxes who almost snatched victory at the death when Pope was forced into his first save of the game to keep out Castagne’s stoppage-time volley. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Juventus docked 10 points with immediate effect over transfer irregularities Tiger Woods withdraws from next month’s US Open Sean Maitland grateful to have Saracens future sorted ahead of Premiership final

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NEW YORK--(BUSINESS WIRE)--May 22, 2023--