List of All Articles with Tag 'f'

Previewing Brighton vs Man City in the Premier League, with TV & live stream details, team news, predicted lineups & score prediction.

As the middle of the year approaches, it’s a smart time to check in on the money goals you set back in January and make any necessary adjustments

Liverpool legend Roberto Firmino is leaving the club this summer, but why is the Brazilian moving on?

JERUSALEM Israel aims to parlay its technological prowess to become an artificial intelligence "superpower", the Defence Ministry director-general

The menopause treatment fezolinetant has been predicted as a “gamechanger” by experts for thousands of women who suffer from hot flushes. The drug, which is the first non-hormonal menopause treatment, was recently approved by America’s FDA. Experts are predicting it could be transformative for women for whom hormone replacement drugs (HRT) are not suitable. The drug was licensed in the US on 12 May and could be approved for use in the UK by the end of the year. According to a British Menopause Society survey, 79 per cent of women aged 45 to 65 experienced hot flushes as a result of their menopause transition, while 10 to 20 per cent describe the hot flushes as “near intolerable”. Here’s everything you need to know about fezolinetant: What is it used to treat? It works to target the menopause symptom of hot flushes. The drug that has been approved by the FDA is made by pharmaceutical company Astella, which advises patients to take one 45-milligram of its VEZOAH (fezolinetant) pill orally, once a day. A large clinical trial of fezolinetant published earlier this year revealed that, after 12 weeks of use, it reduced the frequency of hot flushes by about 60 per cent in women with moderate or severe symptoms, in comparison to a 45 per cent reduction in those who received a placebo. Women involved in the trial also said the drug reduced the severity of hot flushes and improved the quality of their sleep. How does it work? It works by blocking a brain protein called neurokinin-3, which plays a unique role in regulating body temperature in menopausal women. Respondents of the trial have said that the effects of the drug was experienced after taking the first tablet. By comparison, HRT, taken to alleviate menopausal symptoms, replaces the oestrogen that you lose during the menopause transition, either alone or in combination with a progestogen What are the side effects? According to the FDA, the most common side effects are abdominal pain, diarrhoea, insomnia, back pain, hot flush and elevated hepatic transaminases. What have experts said about it? “This is going to be a completely blockbuster drug,” said Prof Waljit Dhillo, an endocrinologist at Imperial College London who led a trial for the drug in 2017 toldThe Guardian. “It’s like a switch. Within a day or two the flushes go away. It’s unbelievable how well these drugs work. It’s going to be completely game changing for a lot of women.” Read More Adenomyosis: 5 things you need to know about the ‘evil twin sister’ of endometriosis ‘Suddenly, I saw Dad again’: The radical technology helping those living with dementia Naga Munchetty reveals womb condition adenomyosis: ‘I live every day on painkillers’

Manchester City are celebrating another Premier League title but their season is far from done as they also target FA Cup and Champions League success. Here, the PA news agency looks at their plans for their coming weeks. How will Pep Guardiola approach their final two Premier League games? With the Premier League title race over, City can afford to ease up for their two remaining league games – away to Brighton and Brentford – before switching attention to their two finals. The line-up for Sunday’s dead rubber against Chelsea, when manager Guardiola named most of his big guns on the bench, showed he intends to lighten his star names’ load. Yet there is also a need to keep players sharp and prevent rustiness. There may be a clue to his thinking in the line-ups for the two Premier League games immediately prior to the Champions League semi-final first leg against Real Madrid. In those matches, against West Ham and Leeds, Guardiola gave all his starting XI against Madrid game time but only one – Erling Haaland – started both. We could see a similar approach with half the first-choice side starting the first game, and the other half the second. Are there any injury concerns? City have had a good season in terms of squad fitness with relatively few injuries. Defender Nathan Ake is currently their only sidelined player with a hamstring problem. The Netherlands international has enjoyed a fine campaign but time is short. He may need to get some action against either Brighton or Brentford to have a chance of starting against Manchester United at Wembley or Inter Milan in Istanbul. What will the approach to the finals from City be? Obviously it is hard to make predictions but it is notable that Guardiola named the same side for City’s three biggest games of recent weeks – the crunch Premier League clash with Arsenal and both legs against Real Madrid. With performance levels in those games outstanding, it would appear he has found his ideal big-match XI. There could be some room for deviation in the FA Cup – for instance Stefan Ortega has been the regular domestic cup starting keeper and Riyad Mahrez’s semi-final hat-trick may earn him another outing – but the side for Istanbul would seem at least pencilled in. Can Manchester United stop City winning the treble? United’s fans may view their own team as the best hope of stopping City emulating their famous 1999 treble. City will be firm favourites to win both finals but Manchester derbies can be unpredictable. City thrashed their neighbours 6-3 in October but United got revenge when they met again at Old Trafford in January. There was some controversy over United’s equaliser in the 2-1 win but the Red Devils proved they can compete with City on a given day. City, of course, have hit their stride since and United’s mid-season charge has slowed, but Erik ten Hag’s team can shine on a one-off occasion. Do Inter pose a threat to City? After thrashing Madrid in the previous round, City seem destined to finally claim the Champions League prize this term. It is difficult to see Inter, currently the fourth best team in Serie A, containing them. Yet the Italians are defensively strong and do pose a threat through the likes of Romelu Lukaku, Lautaro Martinez and former City striker Edin Dzeko, so they may have a puncher’s chance. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live I have lived an absolute dream – Mark Cavendish sets date for cycling retirement Mark Cavendish: The journey from ‘fat banker’ to cycling’s greatest sprinter Mark Cavendish to retire from cycling at the end of the year

TEL AVIV, Israel--(BUSINESS WIRE)--May 22, 2023--

Nottingham Forest are keen to secure loan stars Keylor Navas and Renan Lodi beyond the 2022/23 season.

The boss of a London FX firm was found guilty of seven counts of fraud for his role

Venmo will officially allow teenagers to open an account with their parents' permission, the company said Monday, expanding the popular social payments app to a demographic that is likely to embrace it almost immediately

By almost any measure, the U.S. housing market has yet to emerge from a more than year-long slump, with sales of previously occupied U.S. homes down 28% in the first quarter from a year earlier, and sales of new homes down 16%

(Reuters) -Chevron Corp said on Monday it would acquire PDC Energy Inc in an all-stock transaction for $7.6 billion, including