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Using MRI scans to screen men for prostate cancer could reduce deaths from the disease “significantly”, researchers have suggested. Scientists said current tests, which detect the level of the protein prostate-specific antigen (PSA) in the blood, have been linked to over-diagnosis and over-treatment of low-risk cancer. Prostate cancer is the most common cancer found in men and, at the moment, those aged over 50 can request a PSA test if they are experiencing symptoms. The Reimagine study invited 303 men aged between 50 and 75 to have a screening MRI and a PSA test. Of the total, 48 (16 per cent) had an MRI that indicated the presence of prostate cancer despite having a median PSA density. Of the group, 32 had lower PSA levels than the current screening benchmark of 3ng/ml, meaning they would not have been referred for further investigation. After NHS assessment, 29 men were diagnosed with cancer that required treatment, 15 of whom had serious cancer and a PSA of less than 3ng/ml. Three men (1 per cent) were diagnosed with low-risk cancer that did not require treatment. Our results give an early indication that MRI could offer a more reliable method of detecting potentially serious cancers early Prof Caroline Moore The study was led by University College London, University College London Hospitals NHS Foundation Trust and King’s College London and is published in medical journal BMJ Oncology. Prof Caroline Moore, consultant surgeon at UCLH, chief investigator of the study and NIHR research professor, said the findings are “sobering” and “reiterates the need to consider a new approach to prostate cancer screening”. “Our results give an early indication that MRI could offer a more reliable method of detecting potentially serious cancers early, with the added benefit that less than 1 per cent of participants were ‘over-diagnosed’ with low-risk disease,” she added. Prof Mark Emberton, consultant urologist at UCLH, said: “The UK prostate cancer mortality rate is twice as high as in countries like the US or Spain because our levels of testing are much lower than other countries. “Given how treatable prostate cancer is when caught early, I’m confident that a national screening programme will reduce the UK’s prostate cancer mortality rate significantly. There is a lot of work to be done to get us to that point, but I believe this will be possible within the next five to ten years.” Nick James, a professor of prostate and bladder cancer research at the Institute of Cancer Research in London said the study “further reinforces the value of MRI in the diagnostic pathway for prostate cancer”. “The well-known limitations of the old PSA-based screening studies of over- diagnosis and linked over-treatment are increasingly mitigated by the use of MRI,” he added. “Similarly, MRI can also spot cases of prostate cancer in patients with normal PSA levels, who would have been missed using PSA only screening programmes.” MRI scans have revolutionised the way we diagnose prostate cancer, and it’s great to see research into how we might use these scans even more effectively Simon Grieveson, Prostate Cancer UK Prof Sir Mike Richards, chairman of the UK National Screening Committee (NSC), said the organisation does not currently recommend prostate cancer screening “because there is no clear evidence that the benefits outweigh the harms”. However, it is preparing to look at various proposals. He added: “The UK NSC will soon commission a major piece of work to consider six prostate cancer screening proposals that were submitted during its annual call for topics. “These include targeted and risk-stratified screening proposals for screening groups of men at higher risk due to factors such as ethnicity and family history.” Simon Grieveson, assistant director of research at Prostate Cancer UK, said: “MRI scans have revolutionised the way we diagnose prostate cancer, and it’s great to see research into how we might use these scans even more effectively. “These results are extremely exciting, and we now want to see much larger, UK-wide studies to understand if using MRI as the first step in getting tested could form the basis of a national screening programme.” Another trial, known as Limit, is being conducted with a much larger number of patients, which the research team said is the “next step towards a national prostate screening programme”. The trial will also attempt to recruit more black men, after the team behind Reimagine found they were much less likely to respond to the invitation to screening than others. Saran Green of King’s College London said: “One in four black men will get prostate cancer during their lifetime, which is double the number of men from other ethnicities. “Given this elevated risk, and the fact that black men were five times less likely to sign up for the Reimagine trial than white men, it will be crucial that any national screening programme includes strategies to reach black men and encourage more of them to come forward for testing.”

Jana Kramer has revealed one of her unlikely triggers for morning sickness. During the 21 August episode of her podcast, Whine Down, the singer explained that toothpaste has made her nauseous throughout her pregnancy. “This is gross but, like, the water and mint [of toothpaste] made me want to vomit in the first trimester, so I couldn’t brush my teeth,” she said. “Like, I just used [Colgate] wisps,” she explained, referring to single-use toothbrushes meant to be used on-the-go, as they don’t require toothpaste. Instead, the toothbrushes have a built-in “freshening bead” that dissolves as you brush. The singer explained that she tried to regularly brush her teeth on multiple occasions, before resorting to her other method. “I would try and then I would gag and then I’d puke and so, it just wasn’t worth the extra puke of the day,” Kramer added. During the podcast, she discussed how nervous she was when the time finally came to go to the dentist, after spending three months not brushing her teeth. Luckily, it appeared to have worked in her favour, as her dentist let her know that she “did a really good job for not brushing your teeth in three months.” “He goes, ‘Everything looks good. Where you’re saying the pain is under a cavity, it’s a cavity tooth,’” the One Tree Hill alum said. “So, he’s like, ‘Nothing looks like it’s cracked or seeping or anything.’ He’s like, ‘I can’t do anything anyway ‘cause your pregnant. But a lot of women - when they’re hormonal - it hurts more, your teeth.’” Kramer also shared in her podcast that she recently discovered cavities can be genetic, and that people can end up with poor teeth despite how well they take care of them. “It makes sense now ‘cause my daughter has two cavities - she’s seven - on her adult teeth,” Kramer explained. “So, I’m like, ‘Oh, I gave it to my daughter.’” She shares daughter Jolie, seven, and son Jace, four, with ex-husband Mike Caussin. In June, Kramer announced she and her fiancé, Allan Russell, are expecting their first child together. “We’ve been keeping another secret from you guys (I promise this is the last announcement... at least for a little while) but I’m pregnant!!!!” she captioned an Instagram post. “Beyond blessed and grateful for this baby to be a part of our story. I never thought I would see the word pregnant again on a test, but I’m thankful for @clearblue for making it as clear as ever,” Kramer added. On her podcast, she revealed that they were expecting a boy. In addition to her aversion to toothpaste, the singer also revealed some of her other pregnancy symptoms in an Instagram Story post on 20 August, per US Weekly. “In the first trimester, I couldn’t really stomach anything but a bagel and cream cheese and now the thought of a bagel and cream cheese makes me want to vomit,” she wrote. “I can’t eat any sweets or my stomach hurts. I’m still nauseous throughout the day but it’s worse at night and in the morning.” Read More Jana Kramer claims her ex-husband cheated on her with ‘more’ than 13 women Jana Kramer clarifies Chris Evans ‘bathroom ghosting’ incident Jana Kramer says brief relationship with Chris Evans ended after ‘mortifying’ bathroom incident

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