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Listen to The Big Take podcast on iHeart, Apple Podcasts, Spotify, Terminal. The Inflation Reduction Act has given

The leaders of South America’s Amazon nations will gather in Brazil this week as President Luiz Inacio Lula

By Asif Shahzad ISLAMABAD (Reuters) -Pakistan's jailed former Prime Minister Imran Khan appealed against his conviction and three-year sentence on

Jonnie Irwin has shared an emotional milestone as he cycled with his four-year-old son Rex, on what appeared to be Rex’s last day at nursery. The TV presenter, 49, who is best known for hosting property show A Place in the Sun and Escape to the Country, publicly revealed his diagnosis in November 2022 after his lung cancer spread to his brain. He has previously said he “doesn’t know how long” he has to live. Irwin, who has been receiving palliative care for the past three years, posted an update on Monday (8 August) as he accompanied Rex on his way to nursery. “Last EVER ride to nursery with Rex,” wrote Irwin in a new Instagram post, sharing a series of pictures of himself and Rex on their bicycles as Irwin’s two-year-old son, Rafa, played with a spade. “Suitably waved off by Rafa and his spade and Rex with his game face on!” added Irwin. Irwin, who shares his three boys Rex and twins Rafa and Cormac with his wife Jessica Holmes, detailed his experience of palliative hospice care in a recent interview with BBC Morning Live. The property expert described his hospice experience as a “delight”, adding that his initial perception of such facilities were that they were “very much a boiling hot room full of people who looked frail and towards the end of their days”. However, it was “nothing of the sort” when he did actually go in. “It’s spacious, energised, comfortable,” Irwin told the show, adding: “I’ve had a really, really good experience at my hospice.” He urged anyone who is facing a terminal diagnosis to “embrace” end-of-life care and to try going to a hospice if they have been offered the choice. “My first experience of palliative care and hospice was blood transfusions,” he explained. “I had my first blood transfusion in hospital and then was invited to use the hospice, so I have it a go as a day patient and went into a lovely room. “I implore people to check out hospices. If you’ve got the choice of using it, then use it… I encourage people to explore that option because it’s not the doom and gloom operation you might think it was.” Irwin recently revealed that sometimes he has to “remove himself” from his family home to go to a hospice when he is in a lot of pain because it makes him “not good to be around”. He told Hello! magazine: “I’m like a bear with a sore head and I don’t want [my family] to be around that.” In another appearance with podcast OneChat previously, he said that being in pain affects his mood, explaining: “I have been close to death’s door, twice at least. You lose your memory, you lose your patience. I have got a very short temper. It’s not made me a better person, that’s for sure.” Read More King’s Guard shares sweet exchange with young boy wearing royal uniform ‘Oblivious’ woman defended after walking through beach wedding: ‘They don’t own the beach’ Sandra Bullock’s sister praises actor for being an ‘amazing caretaker’ to late partner Bryan Randall What is ALS and what are the causes? Brain’s appetite control centre different in overweight or obese people – study Areas with lower bird diversity ‘have more mental health hospital admissions’

Sandra Bullock’s longterm partner Bryan Randall has died at the age of 57 after a three-year battle with amyotrophic lateral sclerosis (ASL). His family shared a statement confirming that Randall “passed away peacefully” on Saturday (5 August), adding that he “chose early to keep his journey with ALS private and those of us who cared for him did our best to honour his request”. The statement, sent to People magzine, continued: “We are immensely grateful to the tireless doctors who navigated the landscape of this illness with us and to the astounding nurses who became our roommates, often sacrificing their own families to be with ours.” Bullock and Randall first met in 2015 and made their first public appearance together the following year. The model-turned-photographer’s family has asked for donations to be made to the ALS Association and the Massachusetts General Hospital. ALS affects nerve cells in the brain and spinal cord, its name coming from the Greek and referring to a wasting away of the muscles responsible for controlling voluntary movement caused by a lack of nourishment, the fault of a genetic mutation. As the ALS Association explains: “Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their demise. “When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. When voluntary muscle action is progressively affected, people may lose the ability to speak, eat, move and breathe. “The motor nerves affected when you have ALS are the motor neurons that provide voluntary movements and muscle control. Examples of voluntary movements are making the effort to reach for a smartphone or step off a curb. These actions are controlled by the muscles in the arms and legs.” Early symptoms of the disease, according to the US National Institute of Neurological Disorders and Strokes (NINDS), include: muscle twitches in the arm, leg, shoulder or tongue; cramps; tight or stiff muscles; muscle weakness; slurred or nasal speech; and difficulty chewing and swallowing. “The first sign of ALS usually appears in the hand or arm and can show as difficulty with simple tasks such as buttoning a shirt, writing, or turning a key in a lock,” the NINDS explains. “In other cases, symptoms initially affect one leg. People experience awkwardness when walking or running, or they may trip or stumble more often.” There is currently no cure for ALS but the US Food and Drug Administration has approved four drugs to treat the condition and ease the discomfort of sufferers: Riluzole, Nuedexta, Radicava and Tiglutik. It was first discovered by French neurologist Jean-Martin Charcot in 1869 and is also commonly known as Lou Gehrig’s disease in memory of the celebrated New York Yankees baseman (1903-41) who also suffered from it. While ALS affects all demographics, it is most common among people aged between 55 and 75 and, according to some studies, disproportionately affects former members of the armed forces, perhaps because of exposure to harmful toxins during their service careers although this has not been definitively substantiated. The ALS Association reports that, in 90 per cent of cases of ALS, there is no family history of the genetic mutation that causes the disease and, in the 5-10 per cent of cases in which there is, only a 50 per cent possibility exists of its being passed on. For more information, please visit the websites of the ALS Association or the National Institute of Neurological Disorders and Strokes. Read More Roberta Flack announces she has ALS and finds it ‘impossible to sing’ NIH to fund unproven ALS drugs under patient-backed law ALS drug wins FDA approval despite questionable data Brain’s appetite control centre different in overweight or obese people – study Areas with lower bird diversity ‘have more mental health hospital admissions’ Greg Rutherford rushed to hospital ‘screaming and clawing at his skin’

By David Stanway SINGAPORE Sea ice in the Antarctic region has fallen to a record low this year

Hours after the US women's national team crashed out of the World Cup, former US President Donald Trump seized the opportunity to blame the loss on star player Megan Rapinoe and the country's "woke" path under President Joe Biden.

William Friedkin, director of iconic 1970s films including "The French Connection" and "The Exorcist," has died, his wife Sherry Lansing, the former CEO of Paramount Pictures, told The Hollywood Reporter on Monday.

Global demand for Chinese goods has fallen as the cost of living and rising interest rates bite.

By Li Gu and Summer Zhen SHANGHAI/HONG KONG Investors betting on recovery in China's battered property sector are

Man Utd have unveiled their new third kit for the 2023/24 season.

China's exports suffered their biggest drop in more than three years in July as global demand slowed, adding further pressure on Beijing to find ways to reinvigorate the world's second largest economy.