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A barrage of Russian missiles greeted a delegation of African leaders arriving in Kyiv on Friday as part of a mission aiming to broker peace...

Three years after George Floyd was murdered by then-Minneapolis police officer Derek Chauvin, the Justice Department issued a blistering report Friday of the city's police department, detailing racial discrimination, excessive and unlawful use of force, First Amendment violations and a lack of accountability for officers.

By Jonathan Allen (Reuters) -The U.S. Department of Justice released findings from its two-year investigation of the Minneapolis Police Department

By Howard Schneider Inflation in key parts of the U.S. service industry "remains elevated and has not shown

Micron Technology Inc. warned that about half of its sales tied to China-headquartered clients may be affected by

One of the scientists whose work pioneered the development of medications such as Ozempic and Wegovy has revealed why life may become “so miserably boring” after two years of using the drug. Ozempic is an FDA-approved medication used for the treatment of type 2 diabetes. It works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), which regulates blood sugar levels and slows down the rate at which food leaves the stomach, often creating the feeling of fullness. These semaglutide injections – sold under the brand names Ozempic and Wegovy – have soared in popularity as many people, including Hollywood celebrities, have used it for weight loss. What’s more, people have also found Ozempic has been effective in curing their addictive habits, like drinking, smoking, shopping, or nail biting. However, because of Ozempic’s increasing popularity, it has led to national shortages of the type 2 diabetes treatment – leaving those who actually need it without. In an interview with Wired, professor Jens Juul Holst – who received the Warren Alpert Foundation Prize in 2021 for his work developing treatments based on the GLP-1 hormone – spoke about the effects of Ozempic, and why he believes many people will stop taking the medication after just a few years. “What happens is that you lose your appetite and also the pleasure of eating, and so I think there’s a price to be paid when you do that,” Holst told Wired. “If you like food, then that pleasure is gone. The craving for food for some people is taken away when they take GLP-1 drugs.” He continued: “That may eventually be a problem, that once you’ve been on this for a year or two, life is so miserably boring that you can’t stand it any longer and you have to go back to your old life.” Holst added that medications like Ozempic and Wegovy have been on the market since 2005, though studies show that these people don’t stay on them for very long. “It’s just like every other drug, they don’t stay on it for many reasons,” he explained. “One of the reasons, as I said, is that once you have tried it and you realise you’ve lost interest in food, then that may be enough.” “We don’t know why people stop taking these drugs, but we know for a fact that they do stop. They do that all over the world.” A 2020 study found that 70 per cent of people who took GLP-1 drugs for type 2 diabetes stopped taking them within two years. However, this could pose a problem for many patients taking semaglutide injections. Research has found that people who stopped taking Ozempic or Wegovy for weight loss experienced weight rebound. A trial published in April 2022 saw participants gain back two thirds of the weight they had lost after 68 weeks of taking semaglutide. As for celebrities who use the once-weekly injection for weight loss, despite not having diabetes or clinical obesity, Hans instead called attention to the “many terrible problems” that those with diabetes have struggled with by not having drugs like Ozempic readily available. “Have you ever visited a diabetes hospital? It’s really deplorable,” he said. “People come in with amputated limbs and compromised cognitive functions and heart problems or they can barely move – they’re miserable and depressed. It’s really serious. There is so much you can improve with a drug that is not only a weight-loss drug but is also an anti-diabetic.” Amidst the popularity of semaglutide injections, the US Food and Drug Administration has issued warnings for consumers not to use off-brand versions of Ozempic or Wegovy, because they may not include the same GLP-1 hormone used in approved medications. Earlier this month, agency officials reported problems with patients using compounded versions of semaglutide – which combines traditional semaglutide with other ingredients. These drugs are not FDA-approved, and the agency does not verify the safety or effectiveness of compounded drugs. Consumers should only use drugs containing semaglutide with a prescription from a licensed health care provider and obtained from a state-licensed pharmacy or other facilities registered with the FDA, the agency said. Read More What is ‘Ozempic face’? Doctors warn about facial ageing side effect of diabetes medications How does Wegovy work? The ‘game changing’ weight loss drug beloved by Hollywood FDA warns against using off-brand versions of Ozempic, Wegovy for weight loss Pregnant Stassi Schroeder admits she wants to ‘try’ Ozempic after giving birth Doctors warn about ‘Ozempic face’ side effect of medications Amy Schumer says she stopped taking Ozempic because of side-effects

A group of investors holding more than €1 billion ($1.09 billion) of SBB bonds have hired an adviser

NATO Secretary-General Jens Stoltenberg seems increasingly likely to have his term at the helm of the world’s biggest security organization extended yet again, as members struggle to agree on another candidate to replace him. Stoltenberg, a former Norwegian prime minister, has been NATO’s top civilian official since 2014. His term was due to expire last year but was extended for a second time to keep a steady hand at the helm after Russia’s full-scale invasion of Ukraine in February 2022. President Joe Biden and his NATO counterparts are due to choose a successor when they meet for a summit in Vilnius, Lithuania, on July 11-12. No candidate has been proposed publicly, and leaders usually decide by consensus on who should be appointed. Stoltenberg held talks with Biden in Washington on Tuesday. According to a U.S. official familiar with the leaders’ conversations, Biden made clear that he thinks highly of some the possible candidates whose names have been privately floated to succeed him. The official said, however, Biden conveyed to the NATO secretary-general that it’s “becoming increasingly evident that there’s not going to be consensus” among NATO allies on picking a new leader, said the official, who spoke on condition of anonymity to discuss the private conversation. Biden made it clear to Stoltenberg that he would welcome him sticking around longer — particularly with no end in sight to the war in Ukraine and challenges to get Sweden approved as a member of the 31-nation alliance. “The president thinks Stoltenberg has done a remarkable job over the past year and a half leading the alliance during Russia’s invasion,” the official said. “He’s also quite comfortable with Stoltenberg hanging on. He thinks he’s been a very effective leader.” The official stopped short of saying that Biden asked Stoltenberg outright to stay on as NATO chief. Asked repeatedly Friday about his future at the helm, Stoltenberg said: “I have nothing more to say about this. I have stated again and again that I don’t seek an extension. I have no other plans than to end my work here, when my tenure ends this fall.” The U.S. official also said that Biden had spoken highly of Danish Prime Minister Mette Frederiksen. NATO is keen to name a woman to the top post, and Denmark’s prime minister was thought to be a favorite after a meeting with Biden earlier this month. But in a televised interview on Thursday, Frederiksen said: “No, I am not on my way to NATO.” She did say that she would back Stoltenberg if he was willing to extend his mandate. German Defense Minister Boris Pistorius also made clear that he would back an extension for Stoltenberg if that became necessary. “If we don’t agree on a candidate for successor, NATO won’t be able to go without a secretary-general, and of course I am for an extension — particularly as I appreciate our cooperation,” he told reporters. Norwegian media said Friday that Biden has encouraged Stoltenberg to stay on. Norwegian public broadcaster NRK said it “had learned” that Biden’s message to Stoltenberg “was not to be misunderstood: Jens Stoltenberg must remain as Secretary General of NATO for a while longer.” The president of the European Commission, Ursula von der Leyen, has also ruled out her candidacy. Other possible names that were floated are Dutch Prime Minister Mark Rutte and U.K. Defense Secretary Ben Wallace. ___ Madhani reported from Washington. Associated Press writers Jan M. Olsen in Copenhagen, Denmark. and Geir Moulson in Berlin contributed to this report. Read More Ukraine war’s heaviest fight rages in east - follow live Charity boss speaks out over ‘traumatic’ encounter with royal aide NATO moves to protect undersea pipelines, cables as concern mounts over Russian sabotage threat How significant is the reported recapture of the first Ukrainian villages? Support mounts for Stoltenberg to stay on in NATO's top job

A Vermont man has died in custody while awaiting trial on charges of killing his mother at sea, federal authorities said on Thursday. Nathan Carman, 29, was accused of the first-degree murder of his mother Linda Carman during a 2016 boating trip in what prosecutors alleged was a plot to inherit millions of dollars. Carman pleaded not guilty last year to fraud and first-degree murder and had been due to go on trial in October. The cause of his death was not immediately known. In September 2016, Carman arranged a fishing trip from a Rhode Island marina with his mother, during which his boat reportedly sank and his mother disappeared. Carman was found floating in an inflatable raft eight days later, while his mother has never been found. Prosecutors allege that Carman made alterations to the boat to make it more likely to sink. He was also accused of killing his grandfather, John Chakalos, who was shot dead in his home in Windsor, Connecticut, in 2013. Chakalos’s killing was part of a scheme by Carman to obtain millions of dollars from his grandfather’s estate, according to an eight-count indictment. He had not been charged in that case. Chakalos had made a fortune of tens of millions of dollars by building and renting nursing homes. Last May, Carman was arrested and charged with his mother’s murder. Prosecutors urged him to be held in custody pending trial as he was a flight risk. Carman was being held by US Marshalls at the time of his death. His attorney Martin Minnella told the Associated Press that he had been in good spirits when they spoke on Wednesday, and they had been due to meet again on Thursday. “We were meeting with some experts today over Zoom at 12 o’clock. We were prepared to start picking a jury on October 10 and we were confident we were going to win,” he said. “It’s just a tragedy, a tragedy.” According to prosecutors, Carman’s inheritance scheme began nearly a decade ago when he purchased a rifle in New Hampshire and used it to shoot Chakalos while he was asleep in his Connecticut home on 20 December 2013. Carman then discarded his own computer hard drive and the GPS unit that had been in his truck, according to the indictment. After his grandfather’s death, Carman received $550,000. He moved from Bloomfield, Connecticut, to Vernon, Vermont, in 2014, was unemployed, and by 2016 had squandered most of his inheritance, they alleged. He then organised the fatal boating trip with his mother Linda, of Middletown, Connecticut. In 2019, Chakalos’ three surviving daughters filed a lawsuit in New Hampshire seeking to block Carman from receiving any more of his grandfather’s inheritance. The case was dismissed after a judge ruled that Chakalos was not a New Hampshire resident. It was later refiled in Connecticut and was still pending. The three sisters issued a statement to the AP saying they were “deeply saddened” by Carman’s death. “While we process this shocking news and its impact on the tragic events surrounding the last several years we ask for your understanding and respect relative to our privacy,” they said through a lawyer. Read More Man charged with murdering mother on fishing boat to inherit grandfather’s riches Man found on raft after mother's mystery death at sea was suspect in grandfather's killing Treat Williams death: Everwood and Hair star dies aged 71 following motorcycle accident

A Harvard Medical School morgue manager and his wife are among five people who have been charged with stealing and selling human remains. Cedric Lodge, who was fired on 6 May, allegedly stole “heads, brains, skin and bones” from cadavers that were donated to the school, federal prosecutors in Pennsylvania said on Wednesday. He and his wife Denise sold the body parts to buyers in Pennsylvania and Massachusetts, sending them in the post, according to the indictment. In one case, the buyer allegedly intended to tan skin into leather. The scheme, which is part of a larger black market, is alleged to have gone on from 2018 to 2022. Mr Lodge, who was hired by Harvard in Boston, Massachusetts in 1995, allegedly sometimes allowed potential buyers into the morgue to choose which body parts they wanted. After the horrifying allegations emerged, family members who donated their loved ones’ bodies to medical research spoke of their horror. “We were just disgusted,” Paula Peltonovich, whose father’s remains were donated to the school, told the Boston Globe on Thursday. “Sick, like we were going to throw up.” Read More ‘Disgusted’: Woman speaks out after father’s remains trafficked by Harvard morgue manager ‘Heads, brains, skin and bones’: Everything we know about the Harvard morgue body parts case Niece says she feels ‘sick’ after learning Harvard morgue worker accused of selling human remains Harvard morgue manager ‘sold body parts and human skin that was made into leather’ Harvard Medical School morgue manager, 4 others indicted in theft, sale of human remains

By Sabine Siebold BRUSSELS Rheinmetall will ramp up production of propellant power for ammunition at its plant in

Looking at the best past and present Argentines to play in MLS, including Diego Valeri and Ignacio Piatti.