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One of the scientists whose work pioneered the development of medications such as Ozempic and Wegovy has revealed why life may become “so miserably boring” after two years of using the drug. Ozempic is an FDA-approved medication used for the treatment of type 2 diabetes. It works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), which regulates blood sugar levels and slows down the rate at which food leaves the stomach, often creating the feeling of fullness. These semaglutide injections – sold under the brand names Ozempic and Wegovy – have soared in popularity as many people, including Hollywood celebrities, have used it for weight loss. What’s more, people have also found Ozempic has been effective in curing their addictive habits, like drinking, smoking, shopping, or nail biting. However, because of Ozempic’s increasing popularity, it has led to national shortages of the type 2 diabetes treatment – leaving those who actually need it without. In an interview with Wired, professor Jens Juul Holst – who received the Warren Alpert Foundation Prize in 2021 for his work developing treatments based on the GLP-1 hormone – spoke about the effects of Ozempic, and why he believes many people will stop taking the medication after just a few years. “What happens is that you lose your appetite and also the pleasure of eating, and so I think there’s a price to be paid when you do that,” Holst told Wired. “If you like food, then that pleasure is gone. The craving for food for some people is taken away when they take GLP-1 drugs.” He continued: “That may eventually be a problem, that once you’ve been on this for a year or two, life is so miserably boring that you can’t stand it any longer and you have to go back to your old life.” Holst added that medications like Ozempic and Wegovy have been on the market since 2005, though studies show that these people don’t stay on them for very long. “It’s just like every other drug, they don’t stay on it for many reasons,” he explained. “One of the reasons, as I said, is that once you have tried it and you realise you’ve lost interest in food, then that may be enough.” “We don’t know why people stop taking these drugs, but we know for a fact that they do stop. They do that all over the world.” A 2020 study found that 70 per cent of people who took GLP-1 drugs for type 2 diabetes stopped taking them within two years. However, this could pose a problem for many patients taking semaglutide injections. Research has found that people who stopped taking Ozempic or Wegovy for weight loss experienced weight rebound. A trial published in April 2022 saw participants gain back two thirds of the weight they had lost after 68 weeks of taking semaglutide. As for celebrities who use the once-weekly injection for weight loss, despite not having diabetes or clinical obesity, Hans instead called attention to the “many terrible problems” that those with diabetes have struggled with by not having drugs like Ozempic readily available. “Have you ever visited a diabetes hospital? It’s really deplorable,” he said. “People come in with amputated limbs and compromised cognitive functions and heart problems or they can barely move – they’re miserable and depressed. It’s really serious. There is so much you can improve with a drug that is not only a weight-loss drug but is also an anti-diabetic.” Amidst the popularity of semaglutide injections, the US Food and Drug Administration has issued warnings for consumers not to use off-brand versions of Ozempic or Wegovy, because they may not include the same GLP-1 hormone used in approved medications. Earlier this month, agency officials reported problems with patients using compounded versions of semaglutide – which combines traditional semaglutide with other ingredients. These drugs are not FDA-approved, and the agency does not verify the safety or effectiveness of compounded drugs. Consumers should only use drugs containing semaglutide with a prescription from a licensed health care provider and obtained from a state-licensed pharmacy or other facilities registered with the FDA, the agency said. Read More What is ‘Ozempic face’? Doctors warn about facial ageing side effect of diabetes medications How does Wegovy work? The ‘game changing’ weight loss drug beloved by Hollywood FDA warns against using off-brand versions of Ozempic, Wegovy for weight loss Pregnant Stassi Schroeder admits she wants to ‘try’ Ozempic after giving birth Doctors warn about ‘Ozempic face’ side effect of medications Amy Schumer says she stopped taking Ozempic because of side-effects

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President Vladimir Putin is touting Russia’s prospects at the country’s main international economic forum despite heavy international sanctions imposed because of the war in Ukraine

Tennessee Reps. Justin Pearson and Justin Jones have advanced past an election hurdle after the two young Black lawmakers were expelled earlier this year for their gun control protest on the House floor, then reinstated by local officials days afterward

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South Africa's presidential security chief accuses Polish officials of racism after being stuck on a plane.

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Jennifer Aniston wished her friend and former "Friends" costar Courteney Cox a happy birthday with a throwback message.

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By Nate Raymond The U.S. Supreme Court on Friday preserved the Justice Department's power to unilaterally dismiss lawsuits

President Joe Biden is facing criticism for slipping up when outlining a new railroad project, mistakenly saying it would be built across the Indian Ocean. Mr Biden was speaking to the League of Conservation Voters in Washington DC on Wednesday night, saying, “We have plans to build a railroad from the Pacific all the way across the Indian Ocean”. “We have plans to build in Angola one of the largest solar plants in the world,” Mr Biden added. “I can go on, but I’m not. I’m going off-script. I’m going to get in trouble.” There’s no proposal to build a railroad covering the third largest ocean on the planet, and conservatives were quick to capitalise on the slip-up, with the Twitter account RNC Research sharing the clip on Wednesday night. Last week, during a visit from UK Prime Minister Rishi Sunak, Mr Biden made a similar mistake, before correcting himself, saying that “We’re talking about building — and I had my team putting together with other countries as well — to build a railroad from the Pacific Ocean — from the Atlantic Ocean all the way to the Indian Ocean”. Africa is surrounded by the Atlantic, the Indian Ocean, the Mediterranean, the Red Sea, and the Arabian Sea, but not the Pacific. Before fumbling his words, Mr Biden spoke about how the US is planning on helping developing countries combat the climate crisis. “We’ve mobilised the world’s leading emitters to help poorer countries deal with the impacts of climate change. They called it, at the G7, the Build Back Biden — Build Back Better. And we realized that got confusing,” the president said to laughter in the room. “Here’s the bottom line – We’re the ones that caused the problem, the United States. We cleared all our land. We did all the things that make things more easy for us to make money. Not a bad thing at the time. No one really fully understood,” he added. “But we, the major emitters in the world, have an obligation to help those countries.” “Soon, Africa will have one billion people. China has their Belt and Road Initiative. It turned out to be their debt and destruction initiative. No, I’m serious. Not a joke. Well, we’re going to win, and we’re going to help,” Mr Biden said, seemingly arguing that the US will take on China in their soft power push to help poorer nations with infrastructure projects, which critics have claimed are exploitative, with some calling it a “debt trap”. Mr Biden was mocked by Twitter users for his railroad slip, with conservative columnist Ian Haworth tweeting: “Who’s going to run that train, SpongeBob?” Former Utah Republican Representative Jason Chaffetz tweeted: “Bold initiative, Mr. President.” The communications director for Republican Missouri Senator Josh Hawley, Abigail Marone, wrote: “Put grandpa to bed.” The DeSantis War Room simply tweeted: “Ambitious.” Right-wing commentator Ben Shapiro made a dig about Mr Biden’s age, writing, “He does remember Pangea so.” “I for one am booking a seat on the first ever rail trip to the Indian Ocean. You laugh but the beverage car is gonna be sick,” Philadelphia talk radio host Rich Zeoli wrote. Mr Biden’s reelection effort was endorsed by the League of Conservation Voters Action Fund, the Natural Resources Defense Council Action Fund, NextGen PAC, and the Sierra Club on Wednesday evening, the New York Post noted. Read More Fox News producer behind chyron calling Biden a ‘wannabe dictator’ parts ways with network How was a 21-year-old gamer able to leak a mountain of major Pentagon secrets? Tucker Carlson asks ‘why the hysteria’ over Fox’s Biden ‘wannabe dictator’ chyron US company signs agreement to enter retail fuel market in crisis-hit Sri Lanka US defense secretary discusses upgrading ties with India to counter China Trump gloats as he scores rare legal win in New York golf club tax probe – live

Danielle Hunter holding out for more money from the Minnesota Vikings may not end well.Despite being a three-time Pro Bowl pass-rusher in a Minnesota Vikings uniform, things have been better between Danielle Hunter and the team he plays for.Hunter held out of the Vikings' mandatory mini...