List of All Articles with Tag 'le'

Previewing Brighton vs Man City in the Premier League, with TV & live stream details, team news, predicted lineups & score prediction.

Disney's The Little Mermaid is a classic fable, warning children of the dangers of making

Chelsea will be without one key player when Mauricio Pochettino joins the club.

The menopause treatment fezolinetant has been predicted as a “gamechanger” by experts for thousands of women who suffer from hot flushes. The drug, which is the first non-hormonal menopause treatment, was recently approved by America’s FDA. Experts are predicting it could be transformative for women for whom hormone replacement drugs (HRT) are not suitable. The drug was licensed in the US on 12 May and could be approved for use in the UK by the end of the year. According to a British Menopause Society survey, 79 per cent of women aged 45 to 65 experienced hot flushes as a result of their menopause transition, while 10 to 20 per cent describe the hot flushes as “near intolerable”. Here’s everything you need to know about fezolinetant: What is it used to treat? It works to target the menopause symptom of hot flushes. The drug that has been approved by the FDA is made by pharmaceutical company Astella, which advises patients to take one 45-milligram of its VEZOAH (fezolinetant) pill orally, once a day. A large clinical trial of fezolinetant published earlier this year revealed that, after 12 weeks of use, it reduced the frequency of hot flushes by about 60 per cent in women with moderate or severe symptoms, in comparison to a 45 per cent reduction in those who received a placebo. Women involved in the trial also said the drug reduced the severity of hot flushes and improved the quality of their sleep. How does it work? It works by blocking a brain protein called neurokinin-3, which plays a unique role in regulating body temperature in menopausal women. Respondents of the trial have said that the effects of the drug was experienced after taking the first tablet. By comparison, HRT, taken to alleviate menopausal symptoms, replaces the oestrogen that you lose during the menopause transition, either alone or in combination with a progestogen What are the side effects? According to the FDA, the most common side effects are abdominal pain, diarrhoea, insomnia, back pain, hot flush and elevated hepatic transaminases. What have experts said about it? “This is going to be a completely blockbuster drug,” said Prof Waljit Dhillo, an endocrinologist at Imperial College London who led a trial for the drug in 2017 toldThe Guardian. “It’s like a switch. Within a day or two the flushes go away. It’s unbelievable how well these drugs work. It’s going to be completely game changing for a lot of women.” Read More Adenomyosis: 5 things you need to know about the ‘evil twin sister’ of endometriosis ‘Suddenly, I saw Dad again’: The radical technology helping those living with dementia Naga Munchetty reveals womb condition adenomyosis: ‘I live every day on painkillers’

Sources said Melania Trump tried to increase her allowance and the inheritance of their son Barron, 17, in exchange for support on the 2024 campaign trail

By Simon Lewis WASHINGTON (Reuters) -The Biden administration rebuked Israel on Sunday over an order that allows Jewish settlers to

Elle Fanning looked dazzling in a metallic party dress recently, where fans are impressed with the trust she has in her nipple pasties. The 25-year-old is currently at Cannes Film Festival where she's been photographed wearing beautiful outfits both on the red carpet and out-and-about. But there's one dress in the particular that's had fans talking - a Paco Rabanne silver floor-length dress with intricate feather-like embellishments on the middle to bottom half of the gown. Sign up to our free Indy100 weekly newsletter Meanwhile, the top of the dress followed the metallic theme with two silver nipple covers. "Now THISSSSS is a partyyyy dressss @pacorabanne," she posted on Instagram snaps of herself posing in the dress to her 6.3m followers. Fans took to the comments sections, and had something to say about Fanning's trust in the coordinating nipple pasties. One person said: "You have so much trust in that dress lmao. It’s a stunning look though!" "My nips could never…" another person wrote. Someone else added: "Oh sure, if you have tiny areolas. I could never." "Gorgeous! But my boobs would be so cold!" a fourth person commented. While celebrity pals praised the daring look in the comments section. Lucy Boynton wrote: “Deceeeeeeased," while Naomi Watts added: “I am DEAD [skull emoji],” and Maude Apatow echoed similar sentiment, she commented WOW." Elsewhere at Cannes Film Festival, Harrison Ford's wife was made to sit behind him at Indiana Jones premiere and fans backed Brie Larson after being asked about Jonny Depp. Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

The couple, affectionately known as Bennifer, held hands, laughed together, and even shared a big smooch

New Mexican Spanish is a unique dialect, a mixture of centuries-old Spanish with Indigenous words that evolved through historical isolation

Why be sweltering and sunburnt when you can be swoly and birsled instead?

By Aram Roston and Joseph Tanfani BOCA RATON, Florida Ukrainian-American businessman Lev Parnas and his business partner were

The Shawshank Redemption actor Tim Robbins had a brutally honest response to a conservative author who claimed on Twitter the two ‘hanged out.’ Nick Adams, an Australian-born American Trump supporter, has written numerous books, with his most recent titled The Most Dangerous President in History, written about Joe Biden. Other books of Adams include Trump and Churchill: Defenders of Western Civilisation and Retaking America: Crushing Political Correctness. Adams tweeted a picture of him and Robbins on Friday with the caption ‘hanging out with Tim Robbins at JFK.’ Robbins responded to the tweet by quoting it, adding : ‘not ‘hanging out.’ Dude asked for a picture. I obliged. He left.’ Robbins’ response gained so much attention that Twitter added a community note to Adams’ original tweet that read: ‘According to Tim Robbins, they were not hanging out. When asked to take a photo, Robbins obliged.’ Sign up to our free Indy100 weekly newsletter Many Twitter users loved Robbins’ harsh honesty: Adams didn’t seem to be too happy about Robbins’ clarification, and the piling laughter at his expense. He went on to call Robbins a ‘woke Hollywood liberal.’ Adams Twitter profile proudly displays his belief that he’s an ‘Alpha Male’. As well as his pinned tweet reading: ‘Yes, I am more successful and attractive than you. No, I will not be apologizing for it.’ Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.