Placenta abnormalities could be the reason for miscarriages, study suggests
A new study has found that placenta abnormalities could be the reason for miscarriages. In the United States, there are approximately 5 million pregnancies per year with 1 million ending in a miscarriage and over 20,000 ending in stillbirth, according to a paper published in the journal Reproductive Sciences. “To have a pregnancy loss is a tragedy. To be told there is no explanation adds tremendous pain for these loss families,” said senior author of the paper and research scientist at Yale School of Medicine, Dr Harvey Kliman “Our goal was to expand the current classification systems to decrease the number of cases that remained unspecified.” For the study, researchers worked to create a classification system for miscarriages based on a test that examines a sample of the body’s tissues – known as pathologic examination. The team looked at a series of 1,527 single-child pregnancies that ended in miscarriage, and the data was then sent to Yale for evaluation. After excluding cases without adequate material for examination, 1,256 placentas from 922 patients were examined. Of these, 70 per cent were miscarriages and 30 per cent were stillbirths. By adding the explicit categories of “placenta with abnormal development” (dysmorphic placentas) and “small placenta” (a placenta less than the 10th percentile for gestational age) to other incidents such as cord accident, abruption, thrombotic, and infection – researchers were able to determine the results of 91.6 per cent of the pregnancies, including 88.5 per cent of the miscarriages and 98.7 per cent of the stillbirths. The most common results for unexplained miscarriages were dysmorphic placentas (placenta with abnormal development) which was around 86.2 per cent. For stillbirths, there was 33.9 per cent due to a small placenta. “This work suggests that the over 7,000 small placentas per year associated with stillbirths could have been detected in utero — flagging those pregnancies as high risk prior to the loss,” said Dr Kliman. “Likewise, the identification of dysmorphic placentas may be one way to potentially identify genetic abnormalities in the almost 1 million miscarriages that occur in our country every year.” He said having a definite explanation “for a pregnancy loss helps the family understand that their loss was not their fault, allows them to start the healing process, and, when possible, prevent similar losses — especially stillbirths — from occurring in the future.” When asked what the most effective way might be to prevent stillbirths, Dr Kliman responded, “Measure the placenta!” Read More 'Please, keep beating little heart': Man gives raw account of wife's miscarriage and fears for new unborn child Woman who had six miscarriages celebrates pregnancy with rainbow baby photoshoot Miscarriage: The loneliest grief of all Nearly a fifth of parents fear children will ignore health issues while at university Brits feel their mental health declining due to cost of living crisis How often should you wash your pyjamas?
1970-01-01 08:00
Thieves stole nearly $200 million from Europe's largest copper producer
Fraudsters have robbed Europe's largest copper producer of €185 million ($198 million) worth of the metal, possibly with the help of insiders, the company said Tuesday.
1970-01-01 08:00
Harry Kane and Bayern Munich out to ‘dominate’ Manchester United
Harry Kane says Bayern Munich need to use Manchester United’s issues to their advantage as the England skipper looks to shoot down his long-term admirers in the Champions League. Kane has long been linked with a move to Old Trafford but last month moved to the German giants from boyhood club Tottenham. He has hit the ground running with four goals in as many domestic games as attention turns to Wednesday’s Champions League opener. United are the visitors and the England skipper, 30, maintains Bayern always felt like the right choice for his next club. “To be honest, obviously over the summer I know there were some talks between a few clubs in the background,” Kane said. “But Bayern was a team I was really excited by so there wasn’t too many other discussions once they came in. “My focus is on here. Obviously Manchester are a great club, a really big club as well, but I decided to come here and I’m really happy I have.” Kane joined Bayern in search of silverware that has evaded him for club and country – success that is almost guaranteed with the German behemoths. Trophies have looked far from certain over the last decade at United, who head to Bavaria in a precarious state after a third defeat in four matches compounded their well-documented off-field issues. Kane is wary of a potential backlash but acknowledged United have been going through a “bit of a tough spell recently” that they can capitalise on. “I don’t know about the perfect time (to play them),” he said. “There can be a big response from teams going through a difficult spell but of course we need to use circumstances to our advantage, to go with big confidence at home in front of our fans. “It is important to start the game on the front foot and really try and put the pressure on the opposition. “They have some big threats as well, on the counter-attack they have some really quick players, so we need to be wary of that. “But overall it’s a game we want to try to dominate and try to keep the pressure on and hopefully break them down as the game goes on.” Thomas Tuchel’s Bayern side are strong favourites to win Wednesday’s match and second only to holders Manchester City in the bookmakers’ odds to lift the trophy, but Kane is focusing on further improvements on a personal and collective level. “It’s been a good start for me here for sure,” he said. “Whenever there is a big transfer there is a little bit more pressure and expectation. “Really pleased to score the four goals so far. I still think personally I can play better but I think that will come with getting to know my team-mates more and the system and the way we play. “There’s definitely room for improvement in my all-round game but it’s always good to score four goals in four games.” Kane is the all-time top goalscorer of both England and Tottenham, who have started the season well despite their star turn’s exit. New head coach Ange Postecoglou’s side are unbeaten in the Premier League, with four wins – including one over United – and a draw leaving Spurs second. “They’ve had a fantastic start,” Kane said. “I’m always keeping an eye on them and I’ll keep an eye on Tottenham for the rest of my life. “I’m really happy to see the team playing the way they are and to see the fans happy is a great thing.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Italy boss Kieran Crowley wary of ‘massive threat’ posed by Uruguay Harry Kane defends ‘scapegoated’ Harry Maguire amid ‘unnecessary scrutiny’ Chris Billam-Smith confident of Lawrence Okolie win but doubts appeal of rematch
1970-01-01 08:00
Ex-NFL player missing after mother found murdered
Police have not named former Patriots player Sergio Brown as a suspect or a person of interest.
1970-01-01 08:00
European soccer could see more disruption from Azerbaijan-Armenia conflict over disputed region
International soccer games could again be affected by the territorial dispute between Azerbaijan and Armenia that reignited Tuesday
1970-01-01 08:00
SpaceX says US case alleging anti-immigrant bias is unconstitutional
By Daniel Wiessner Elon Musk's SpaceX has sued the U.S. government saying that the government's administrative case accusing
1970-01-01 08:00
US has no evidence Huawei can produce advanced smartphones in large volumes -- official
By David Shepardson WASHINGTON U.S. Commerce Secretary Gina Raimondo said Tuesday the United States has no evidence that
1970-01-01 08:00
New Fortnite Birthday Reality Augments: Full List
The new Fortnite Birthday Reality Augments in the Sept. 19 Hotfix include Jump Balloon, Shell Slide, and Bloodhound.
1970-01-01 08:00
Fortnite Birthday Quests: How to Complete, Rewards
To complete the Fortnite Birthday Quests and earn free in-game rewards, players must find Birthday Presents, Birthday Cake, and Balloons.
1970-01-01 08:00
The leaked footage of US Only Fools and Horses remake should come with a trigger warning
Leaked footage has revealed a US remake of Only Fools and Horses was in the works and it was absolutely terrible. Only Fools and Horses is arguably one of the most iconic sitcoms to have ever appeared on British television after its 1981 pilot. At its peak, the show drew millions of viewers and smashed TV rating records at the time, with the characters Del Boy and Rodney becoming a part of British comedy culture. Now, it appears America was trying to replicate some of that success on the other side of the Atlantic by attempting to adapt the show into a US version in 2012. Bar a few exceptions, US remakes have historically done horribly and it seems Only Fools and Horses, renamed Kings of Van Nuys, was no different. TV network ABC commissioned two separate pilots and decided to pass on picking up either of them. And, judging by footage leaked online, it’s not hard to see why. A clip was shared online by comedian Tom Mayhew, who wrote: “In 2012, a US remake of Only Fools and Horses was produced. It has recently leaked online. “This is a Trigger warning, for nothing I can say will adequately prepare you for what they did to the beloved British character.” “I've seen hostage tapes that are funnier,” one viewer remarked. Another wrote: “‘US remake of only fools and horses’ instilled in me a deep visceral fear.” “Might have ruined my week, definitely my day,” said someone else. Mayhew elaborated further on his disgust in a YouTube video, in which he explained: “I feel the problems with this adaptation can be summed up in a few sentences. One, I feel like they've missed the whole underclass, working-class aspect of it and just gone, ‘Oh, wouldn't it be funny to do a show about a dodgy Wheeler Dealer and to put them in these crazy situations’. “And they've completely missed one of the great things about the show, was the fact it did show but like a normal family in relatively normal situations and that's why people loved it. “Two they've missed the drama. [...] And three, tonally just all over the place. So yeah, I wouldn't recommend you watch it.” Sign up to our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.
1970-01-01 08:00
Black Texas student given additional suspension for loc hairstyle
A Black Texas high school student who was suspended because his loc hairstyle violated the district's dress code was suspended again upon his return to school Monday, an attorney for the family told CNN.
1970-01-01 08:00
Microsoft Mistakenly Posts Secret Game Plans to Government Site
Microsoft Corp. mistakenly uploaded confidential information about its video-game operations to a federal court website, according to a
1970-01-01 08:00
