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Microsoft has made a major concession to UK authorities in a bid to remove the last remaining regulatory obstacle to its huge takeover of Activision Blizzard.

There are more than 47,000 men diagnosed with prostate cancer every year in England but new research says using MRI scans can reduce deaths caused by the disease. Current tests usually detect the level of the protein prostate-specific antigen (PSA) in the blood, but scientists say this has meant overdiagnosis and overtreatment of low-risk cancer. The Reimagine study, by University College London, University College London Hospitals NHS Foundation Trust and King’s College London, invited 303 men aged between 50 and 75 to have a screening MRI and a PSA test. Of those men, 48 (16%) had an MRI that indicated prostate cancer despite having a median PSA density – 32 of those had lower PSA levels than the current screening benchmark, meaning they would ordinarily not have been referred for investigation. After NHS assessment 29 were diagnosed with cancer that required treatment, and three were diagnosed with low-risk cancer with no need for treatment. Prof Caroline Moore, consultant surgeon at UCLH, chief investigator of the study and NIHR research professor, called the findings “sobering”. She said: “Our results give an early indication that MRI could offer a more reliable method of detecting potentially serious cancers early, with the added benefit that less than 1% of participants were ‘over-diagnosed’ with low-risk disease.” What is prostate cancer? Prostate cancer is the UK’s most common male cancer. It affects the prostate – a walnut-sized gland that sits beneath the bladder and surrounds the urethra in people born with male sex organs. Its main purpose is to help produce semen (the fluid that carries sperm). Prostate cancer can develop when cells in the prostate start to grow in an uncontrolled way. While some prostate cancers grow quickly and spread, others grow too slowly to cause any problems and therefore will never need any treatment. What are the risk factors “Prostate cancer is a disease we tend to see in older age groups (over-50s), but there are exceptions, as with any form of cancer,” said Dr Sanjay Mehta, GP at The London General Practice. According to Prostate Cancer UK black men are at a higher risk – one in four black men will get prostate cancer in their lifetime (compared to one in eight for other men). The risk increases after the age of 45. Family history is important too; your father or brother has had prostate cancer or your mother or sister has had breast cancer, your risk is higher. What are the symptoms? Often there aren’t any signs in the early stages, so be aware of your own risk factors and chat to your doctor if concerned. Prostate Cancer UK have an online risk checker you can use too. Mehta said to watch out for urinary symptoms and changes to how you urinate. “So frequency, where you need to go more often. Hesitancy, where you’re standing over the toilet bowl and a period of time will pass before you’re able to pass urine, and ‘dribbling’, where you’ve finished but find you’re still passing when you walk away. “These are common in older men anyway. But if it’s new for you, and you find you’re having to go more often at night, and you’re having hesitancy or urgency, see your doctor.” Other things to get checked include erectile dysfunction, blood in your urine, and any new and unexplained lower back pain. “Then there are general systemic symptoms, like lethargy, lack of appetite,” added Mehta. “Again, these things often happen anyway, but if it’s a change for you and it’s been happening for a couple of weeks, see your doctor.” How is prostate cancer diagnosed and treated? First, your doctor will chat through your symptoms and history with you. “The next step would involve an examination, including a rectal examination of the prostate,” said Mehta, before referral for further investigations. “I appreciate this can put some men off seeing their doctor but it is a very helpful way of assessing things”. After diagnosis, treatment depends on the stage of the cancer and what’s suitable for each individual, but it may include surgery or radiotherapy. Caught early, prostate cancer is generally very treatable. And even with advanced prostate cancer, treatments have come a long way. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Keep fit to avoid heart rhythm disorder and stroke, study suggests How to give your home a proper summer sort out What you really need to do in autumn to keep your lawn in shape

LONDON Turkish grocery delivery firm Getir announced a global restructuring on Tuesday, saying it plans to cut 2,500

Even after a record slump that wiped out €21 billion ($23 billion) in value, some investors think Adyen

If you ever needed a reminder that the planet is dying and football has become a complete circus, then just take a look at the latest in the Neymar transfer saga. Neymar da Silva Santos Júnior has completed his move from Paris Saint Germain to Al Hilal, becoming the latest name to make the switch to Saudi Arabia. The moral implications of joining a side funded by the Saudi sovereign wealth fund are one thing, but he’s recently come under fire for the method of transport he took to travel to join up with his new side. The 31-year-old took the private Boeing 747 owned by Alwaleed bin Talal over, at a huge environmental impact. Neymar had the entire plane to himself, with only the crew joining him on board. The carbon footprint of the flight is thought to be around 858 tonnes. That works out to be 85 times the environmental impact of the average person in the UK per year. Something to think about the next time you sort the recycling, perhaps. It’s pretty concerning that something so damaging can be taken out on a whim as a publicity stunt – and people on social media have been voicing their criticism. “Can’t believe I have to eat out of paper straws while people fly private! Such a waste of time,” one social media user wrote. Neymar won’t care, of course. He’s on his way to play in the Saudi league for a reported 100 million euros (£86.3m) per year. He joins the likes of Cristiano Ronaldo, Karim Benzema, Riyad Mahrez, Jordan Henderson, Sadio Mane and N’Golo Kante in moving to the Middle East. The move ends his six-year stay at PSG, who he joined from Barcelona for a world-record £200m fee in 2017. He’ll team up with former Wolves captain Ruben Neves and ex-Chelsea defender Kalidou Koulibaly at Al Hilal. Sign up for our free Indy100 weekly newsletter Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

If Gwendoline Christie had listened to bullies when she was younger, she might never have become an actress

Lowe's Cos posted a smaller-than-expected drop in quarterly comparable sales and topped estimates for profit on Tuesday, helped

Ubisoft Entertainment SA shares rose the most since February after Microsoft Corp. offered the French video game publisher

Lewis Hall joins Newcastle from Chelsea on loan with obligation to buy.

Keke Palmer has heaped praise on Sergio Hudson, explaining that his designs help to "accentuate" her figure.

Sabrina Carpenter has helped to launch a new fragrance called Sweet Tooth: Caramel Dream.

Tiffany Young has been named as Moschino's new house ambassador.