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DUBAI (Reuters) -Ali Shamkhani, long-time ally of Iran's supreme leader, has stepped down as the country's top security official, Iranian

Despite increasing public awareness of endometriosis, with celebrity figureheads including Lena Dunham and Molly Mae, the condition’s ‘evil twin sister’, adenomyosis, remains neglected. While the NHS has an entire webpage which explains what endometriosis is, there is currently no equivalent for its sister condition. Read on for five things you should know. It’s not the same as endometriosis Both endometriosis and adenomyosis occur when the lining of the uterus (known as the endometrium) grows out of place, but there are major differences between the two. In endometriosis, the rogue tissue invades areas outside of the uterus. While the extent of the growth varies from patient to patient, it can affect areas such as the bladder, bowel, ovaries, and even the lungs. Adenomyosis, on the other hand, causes the rogue tissue to bury inside the muscular wall of the uterus. It’s possible to suffer from both conditions at the same time. Symptoms include bloating, heavy periods, and pelvic pain Thanks to the invasive endometrial growth, adenomyosis is characterised by an enlarged uterus. During menstruation, the embedded tissue swells and bleeds, typically causing a variety of symptoms (although some women are asymptomatic). According to a patient leaflet published by University College Hospital, sufferers commonly have painful and irregular periods, with more than half experiencing heavy bleeding. Chronic pre-menstrual pain, and feelings of heaviness and discomfort in the pelvis are among other possible symptoms. Less frequently, adenomyosis can cause bloating, pain during intercourse, and pain related to bowel movements. All symptoms should stop after the menopause. It affects 1 in 10 women The condition is believed to affect 10 per cent of women in the UK. That makes it just as prevalent as endometriosis, although it’s more common in women between the ages of 40-50, and those who have been pregnant before. While the cause of the condition is not known, UCH says that “genetics and some hormones may play a role”. In terms of long-term effects, the North Bristol NHS trust says that adenomyosis does not appear to decrease the chance of pregnancy, however it has been linked to an increased risk of miscarriage and premature birth. Treatment options are limited For women with mild symptoms, trying to get pregnant, or nearing menopause, the North Bristol trust says that treatment may not be necessary, but for those seeking relief from symptoms, it recommends medication to reduce pain and bleeding, and hormonal interventions such as the contraceptive pill. The only “cure” is a surgical procedure involving the removal of the womb (hysterectomy), although this is a last resort intervention. The Bristol-based trust also offers an alternative surgery which involves blocking the blood supply to the endometrial growth, forcing it to shrink, but neither procedure is advisable for women who want to get pregnant in the future. It can take years to diagnose The condition is typically diagnosed using MRI and ultrasound scans, but the NHS says that adenomyosis can take “a long time, even years, to diagnose” because “symptoms and severity can vary between women”. The frequent dismissal of women’s gynaecological symptoms means that signs of adenomyosis may be conflated with ‘normal’ menstruation, or even other conditions such as endometriosis. Anecdotal reports of sufferers suggest that misdiagnosis is common. Gabrielle Union, one of the only celebrities to have publicly identified as having the condition, suspects her condition went undiagnosed for years. Speaking at a conference in 2019, Union explained: “The gag is I had [adenomyosis] in my early twenties, and instead of someone diagnosing me they were like ‘Oh you have periods that last nine or 10 days and you’re bleeding through overnight pads? Not a mere inconvenience... perhaps there’s something more there.’” Earlier this year, the charity Tommy’s reported that the condition might be “underdiagnosed” after a review of existing studies found that “mild” cases could be missed by clinicians using current diagnostic methods. “There should be training for clinicians and sonographers to diagnose adenomyosis using a standardised criteria,” said Dr Ishita Mishra, leader of the review. “Being able to identify this condition using a uniform set of criteria would then help give us a true picture of the numbers affected, and better understanding of the impact of this condition,” Mishra explained. If you have any health concerns, you should always contact your GP in the first instance. There is also information available via NHS Scotland or Endometriosis UK. Read More Lena Dunham marks five years of sobriety: ‘Happiest of my time on earth’ ‘Some days things just do not work’: What happens when your smear test doesn’t go smoothly? Woman’s warning after terminal cancer mistaken for heavy periods 5 things you need to know about adenomyosis, the ‘evil twin sister’ of endometriosis Woman’s warning after lip filler left her unable to close mouth ‘Suddenly, I saw Dad again’: The radical tech helping those living with dementia

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Conor McGregor has insisted that he will fight Michael Chandler before the end of the year, amid fan concerns that the UFC clash will not take place at all. It was announced in early February that McGregor and Chandler would serve as opposing coaches on the new season of The Ultimate Fighter, which airs between 30 May and 15 August, before fighting each other. However, no date, location or weight class has been confirmed for the bout. McGregor is also absent from the United States Anti-Doping Agency’s testing pool. Fighters must be in the pool for six months and return two negative tests (and zero positives) in order to compete in the UFC. As a result, McGregor must enter the pool imminently if he is to fight before the end of 2022. “That’s done, man,” Conor McGregor claimed in an interview with the Daily Mirror at the weekend. “That’s done. I’m ready. “By year-end, I’m back in that cage, having competed. I’m gearing up now, ready to go. “The fight’s signed now. It’ll be announced during The Ultimate Fighter. So, The Ultimate Fighter is airing in a few days on ESPN; by the time that show finishes, we’ll have a date and everything set for the fans.” Irishman McGregor, 34, has not fought since July 2021, when he suffered a broken leg in a TKO loss to Dustin Poirier. Meanwhile, Chandler also lost to Poirier in his most recent bout, having been submitted by his fellow American in November. Last week, the second documentary covering McGregor’s career was released on Netflix. McGregor Forever covers the former dual-weight champion’s fights with Khabib Nurmagomedov and Donald Cerrone, his back-to-back losses to Poirier in 2021, and his recovery from his broken leg. Read The Independent’s review of the four-part series here. Click here to subscribe to The Independent’s Sport YouTube channel for all the latest sports videos. Read More McGregor Forever: The problem with the new Conor McGregor documentary Conor McGregor cheers on Katie Taylor from ringside during Chantelle Cameron fight Joe Rogan is right: Tyson Fury has ‘no chance in hell’ against Jon Jones

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