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What is ALS and what are the causes?
What is ALS and what are the causes?
Sandra Bullock’s longterm partner Bryan Randall has died at the age of 57 after a three-year battle with amyotrophic lateral sclerosis (ASL). His family shared a statement confirming that Randall “passed away peacefully” on Saturday (5 August), adding that he “chose early to keep his journey with ALS private and those of us who cared for him did our best to honour his request”. The statement, sent to People magzine, continued: “We are immensely grateful to the tireless doctors who navigated the landscape of this illness with us and to the astounding nurses who became our roommates, often sacrificing their own families to be with ours.” Bullock and Randall first met in 2015 and made their first public appearance together the following year. The model-turned-photographer’s family has asked for donations to be made to the ALS Association and the Massachusetts General Hospital. ALS affects nerve cells in the brain and spinal cord, its name coming from the Greek and referring to a wasting away of the muscles responsible for controlling voluntary movement caused by a lack of nourishment, the fault of a genetic mutation. As the ALS Association explains: “Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their demise. “When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. When voluntary muscle action is progressively affected, people may lose the ability to speak, eat, move and breathe. “The motor nerves affected when you have ALS are the motor neurons that provide voluntary movements and muscle control. Examples of voluntary movements are making the effort to reach for a smartphone or step off a curb. These actions are controlled by the muscles in the arms and legs.” Early symptoms of the disease, according to the US National Institute of Neurological Disorders and Strokes (NINDS), include: muscle twitches in the arm, leg, shoulder or tongue; cramps; tight or stiff muscles; muscle weakness; slurred or nasal speech; and difficulty chewing and swallowing. “The first sign of ALS usually appears in the hand or arm and can show as difficulty with simple tasks such as buttoning a shirt, writing, or turning a key in a lock,” the NINDS explains. “In other cases, symptoms initially affect one leg. People experience awkwardness when walking or running, or they may trip or stumble more often.” There is currently no cure for ALS but the US Food and Drug Administration has approved four drugs to treat the condition and ease the discomfort of sufferers: Riluzole, Nuedexta, Radicava and Tiglutik. It was first discovered by French neurologist Jean-Martin Charcot in 1869 and is also commonly known as Lou Gehrig’s disease in memory of the celebrated New York Yankees baseman (1903-41) who also suffered from it. While ALS affects all demographics, it is most common among people aged between 55 and 75 and, according to some studies, disproportionately affects former members of the armed forces, perhaps because of exposure to harmful toxins during their service careers although this has not been definitively substantiated. The ALS Association reports that, in 90 per cent of cases of ALS, there is no family history of the genetic mutation that causes the disease and, in the 5-10 per cent of cases in which there is, only a 50 per cent possibility exists of its being passed on. For more information, please visit the websites of the ALS Association or the National Institute of Neurological Disorders and Strokes. Read More Roberta Flack announces she has ALS and finds it ‘impossible to sing’ NIH to fund unproven ALS drugs under patient-backed law ALS drug wins FDA approval despite questionable data Brain’s appetite control centre different in overweight or obese people – study Areas with lower bird diversity ‘have more mental health hospital admissions’ Greg Rutherford rushed to hospital ‘screaming and clawing at his skin’
1970-01-01 08:00
No quick fix to reverse Antarctic sea ice loss as warming intensifies - scientists
No quick fix to reverse Antarctic sea ice loss as warming intensifies - scientists
By David Stanway SINGAPORE Sea ice in the Antarctic region has fallen to a record low this year
1970-01-01 08:00
Trump blames Megan Rapinoe and wokeness for US Women's World Cup exit
Trump blames Megan Rapinoe and wokeness for US Women's World Cup exit
Hours after the US women's national team crashed out of the World Cup, former US President Donald Trump seized the opportunity to blame the loss on star player Megan Rapinoe and the country's "woke" path under President Joe Biden.
1970-01-01 08:00
Football transfer rumours: Real Madrid to reach Mbappe agreement; Amrabat rejects Man Utd
Football transfer rumours: Real Madrid to reach Mbappe agreement; Amrabat rejects Man Utd
Tuesday's football transfer rumours, with updates on Kylian Mbappe, Sofyan Amrabat, Neymar, Harry Kane, Bernardo Silva & more.
1970-01-01 08:00
German airport operator Fraport sees earnings boost on high travel demand
German airport operator Fraport sees earnings boost on high travel demand
(Reuters) -Frankfurt Airport operator Fraport on Tuesday said its 2023 core profit would hit the upper half of its forecast
1970-01-01 08:00
Wemade’s MMORPG MIR M Updates New Inter-server Area ‘Prajna Island’
Wemade’s MMORPG MIR M Updates New Inter-server Area ‘Prajna Island’
SEOUL, South Korea--(BUSINESS WIRE)--Aug 8, 2023--
1970-01-01 08:00
Euro zone consumers expect lower inflation, sluggish housing prices - ECB poll
Euro zone consumers expect lower inflation, sluggish housing prices - ECB poll
FRANKFURT Euro zone consumers expect inflation to keep slowing in the next months and years but remain pessimistic
1970-01-01 08:00
Investors bet on state-backed developers as Chinese property begins recovery
Investors bet on state-backed developers as Chinese property begins recovery
By Li Gu and Summer Zhen SHANGHAI/HONG KONG Investors betting on recovery in China's battered property sector are
1970-01-01 08:00
Man Utd unveil adidas third kit for 2023/24 season
Man Utd unveil adidas third kit for 2023/24 season
Man Utd have unveiled their new third kit for the 2023/24 season.
1970-01-01 08:00
Xsolla Removes Barriers for Direct to Consumer Distribution With Integrated Parental Control Feature for Game Developers
Xsolla Removes Barriers for Direct to Consumer Distribution With Integrated Parental Control Feature for Game Developers
LOS ANGELES--(BUSINESS WIRE)--Aug 8, 2023--
1970-01-01 08:00
The best spa hotels in Dorset for luxury and relaxation
The best spa hotels in Dorset for luxury and relaxation
What makes a holiday in Dorset? Maybe it’s fish and chips at the seaside, or hiking to the highest point on England’s south coast before rewarding yourself with a pint of local beer. Or visits to nude hill figures or an iconic limestone arch might take your fancy. This jewel of the West Country has things to do in spades – eating, drinking, active or laidback – plus plenty of on-trend hotels in which to lay your head. If Dorset’s much-extolled salted sea air and bucolic tranquillity isn’t enough to bring you utter relaxation, you’re in luck. Among the county’s hills and on its rugged coast are hotels that have getting guests to unwind baked into their being. Think warmed underground pools, blissful treatments ranging from traditional through modern, and space to just… be. There’s more to Dorset than just apple cake and Thomas Hardy. If you want a UK getaway – and to give your wellbeing a holistic boost – these are the best spa hotels in Dorset to book. The best spa hotels in Dorset are: Best for style by the sea: The Nici Best for the traditional approach: Summer Lodge Country House Hotel Best for a hidden escape: The Eastbury Best for a foodie getaway: Christchurch Harbour Hotel & Spa Best for coastal cool: The Pig on the Beach Best for style by the sea: The Nici Location: Bournemouth The hotel that Bournemouth – overstocked with dowdy, dated seaside accommodation – has been crying out for. Inside, spaces are filled with art, tropical prints and a hint of Art Deco; outside, the star is a 30m heated pool, very much a nod to Miami’s South Beach, and the town’s long stetch of sand can be reached by a short zig-zag path. If you can wrench yourself from a cabana, The Nici’s swish spa beckons, all soft lighting and gentle music (a change from the pumping soundtrack poolside). Treatments incorporate products from British “nutri-cosmeceutical” beauty brand Oskia, as well as CBD pioneers OTO. The latter’s Nici signature massage is a joy, where CBD-infused oils soothing tired muscles and dislodge long-held knots; afterwards, curl up in the relaxation space and pop open a can of OTO’s CBD seltzer, before making use of the steam room, sauna and indoor pool (or the gym, if you feel suitably energised post-treatment). Best for the traditional approach: Summer Lodge Country House Hotel Location: Evershot Summer Lodge remains Dorset’s countryside grande dame (and the county’s only five-star hotel). The quintessential rural pad, it has beautifully restored rooms with high ceilings, watercolours, and chandeliers. The four-acre estate is set in Evershot, a village little changed since it featured in local author Thomas Hardy’s Tess of the d’Urbervilles (and while there, prop up the bar or sit beside the fire at the trad-yet-cool Acorn Inn). The spa is a major highlight of Summer Lodge, packed with Elemis treatments, from deep-cleansing facials through to rejuvenating wraps, plus a hefty list of massages and manicures. Bespoke spa packages can be arranged depending on the occasion, and if you’re on a family break there are special “junior” treatments for younger guests. Wellbeing extends to a gym, sauna and heated indoor pool, and there are quiet corners of the fragrant gardens in which to unwind in private. Best for a hidden escape: The Eastbury Location: Sherborne This is perhaps the prettiest little spa in the West Country, hidden at the bottom of The Eastbury’s walled garden and reminiscent of a Hobbit hole. Only the occasional ringing of bells from the abbey reminds you that you’re in the historic market town of Sherborne. There are two treatment rooms, where massage therapy mollifies any pesky aches, as well as a hydrotherapy tub, sauna and relaxation areas which you have all to yourself (you book the space by the hour). The hotel dates from the 18th century, built as gentleman’s townhouse, so expect plenty of traditional style as well as modern touches brought in during a 2018 refurb. Since the start of 2023, they no longer have a restaurant (a shame, as chef Matthew Street’s tasting menus were impressive) but instead offers breakfast, light lunches and afternoon tea. Best for a foodie getaway: Christchurch Harbour Hotel & Spa Location: Christchurch Christchurch’s natural harbour is wonderful sweep of the Dorset coast, and the best ways to soak up its views – over to Mudeford Spit and its expensive beach huts, and beyond to the Channel – is by staying at its namesake hotel. The 1930s property has a blended palette of muted and vibrant tones inside, and right on the water is its headline restaurant, The Jetty. It’s seafood-heavy menu comes from Alex Aitkin, who held a Michelin star at Le Poussin; for a reliable, fresh taste of local waters, plump for the catch of the day. The HarSpa is found below-ground – they describe it as “subterranean” – and is lit by coloured spotlights around a heated pool and whirlpool tub. While away a day on one of the sun loungers (indoor and outdoor), an activity you can break up with Espa beauty treatments or full-body massages. The spa menu also features offerings designed specifically for men and pregnant women. Best for coastal cool: The Pig on the Beach Location: Studland The litter of Pig hotels has one of its very finest locations in east Dorset, at the edge of land overlooking the Old Harry Rocks chalk formation. There’s whimsy in the turrets and sloping roofs that make up the 16th-century manor, and – in classic Pig aesthetic – there’s a surrealism in the luxe Victoriana-meets-countryside décor. The restaurant makes use of the county’s incredible larder, only sourcing produce within a 25-mile radius, and its menu favours unfussy, well-paired flavours. Don’t forget to visit the pigs and sheep in their pens, which you can hear as you knock back cocktails (try the rum-drenched Jungle Pig 2.0) on the lawn. Beyond the garden, which guests can discover down a path, are two adorable shepherd’s huts. These comprise the spa, simple and understated. They’re very Mr McGregor’s garden (of The Tale of Peter Rabbit fame) in style, in keeping with the kitchen garden ethos of the restaurant. The six treatments, each 60 minutes and costing £115, use products from the County Sligo seaweed brand VOYA. thepighotel.com Read more on the best Dorset hotels
1970-01-01 08:00
China's economy suffers new blow as exports drop 14% in July
China's economy suffers new blow as exports drop 14% in July
China's exports suffered their biggest drop in more than three years in July as global demand slowed, adding further pressure on Beijing to find ways to reinvigorate the world's second largest economy.
1970-01-01 08:00
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